5 ms·

True, failed to mention that I never drink caffeine after 2pm. I never understood how some people can have a coffee in the evening and go to bed just fine.

FirmwareBurner 3y ago
>I never understood how some people can have a coffee in the evening and go to bed just fine By building tolerance and genetics.
- amelius 3y ago
  Regarding genetics, are there enzymes that some people lack, and that they can take to digest caffeine better?
  - pillefitz 3y ago
    This one https://en.m.wikipedia.org/wiki/CYP1A2 https://en.m.wikipedia.org/wiki/CYP1A2. I've read somewhere that eating Broccoli enhances its activity, but likely too much is needed to have noticable effects from what I recall. If only there was a short-acting stimulant and antidote available as a combo..
    - salad-tycoon 3y ago
      Of course, that’s called a speed ball. An upper and downer. Also poppers and screamers and small world. “We buy drugs” whitest kids u know : https://m.youtube.com/watch?v=I2AQ6FwpSrc https://m.youtube.com/watch?v=I2AQ6FwpSrc Anyways, in all seriousness the idea of taking something and then taking something else later to counteract the effects, not good but popular in black, gray, and white market. I think this weekend I’ll give up caffeine, I’m a slow metabolizer.
      - pillefitz 3y ago
        I was thinking more in terms of actual antidote by either binding the active substance or speeding up its metabolism, rather than having two substances acting in opposing directions. Anyway, I gave up caffeine earlier this year and am quite happy with the results. Steady and calm energy, no frantic meandering of thoughts, no clinging to details anymore. Once every few weeks I'm craving the euphoric buzz and drink half an Espresso, but typically regret it later the same day as I'm unable to sleep and, interestingly, tend to wake up in the middle of the night for a couple of days after.
    - amelius 3y ago
      > If only there was a short-acting stimulant and antidote available as a combo.. I know that energy drinks use taurine to combat some of the effects of caffeine, but I don't think it will work for sleep.
  - deleted 3y ago
    [deleted]
- fjfuvucucuc 3y ago
  And age. I used to do this fine in my 20s. 30s not so much.
- growingkittens 3y ago
  Or by having ADHD - coffee before bed can give me just enough focus to fall asleep.
Lewton 3y ago
2pm might not be early enough. Depending on genetics the half life of caffeine in your system can vary by a lot. Even if you're in the normal range, a half life of 4-6 hours means that ~25% of the caffeine would still be in your system by midnight... If you're that worried about sleep quality, it's baffling you have not tried cutting out caffeine altogether
- garrickvanburen 3y ago
  No caffeine after 10am here.
  - balfirevic 3y ago
    None of the statements "no coffee after XX" make sense without specifying when you go to sleep.
    - garrickvanburen 3y ago
      I’m not sure the marginal difference between say 8p and midnight is material with a 10a cutoff.
RoyalHenOil 3y ago
For me, caffeine aids sleep. I find it much easier to make myself stop excessively thinking about things when I am caffeinated. However, if I have caffeine too early in the day, it makes it harder to clear my mind and sleep that night than if I had no caffeine at all. For this reason, I aim to only have caffeine after 3pm (preferably later, depending on when I plan to go to bed).

FirmwareBurner 3y ago

>I never understood how some people can have a coffee in the evening and go to bed just fine By building tolerance and genetics.

amelius 3y ago
Regarding genetics, are there enzymes that some people lack, and that they can take to digest caffeine better?
- pillefitz 3y ago
  This one https://en.m.wikipedia.org/wiki/CYP1A2 https://en.m.wikipedia.org/wiki/CYP1A2. I've read somewhere that eating Broccoli enhances its activity, but likely too much is needed to have noticable effects from what I recall. If only there was a short-acting stimulant and antidote available as a combo..
  - salad-tycoon 3y ago
    Of course, that’s called a speed ball. An upper and downer. Also poppers and screamers and small world. “We buy drugs” whitest kids u know : https://m.youtube.com/watch?v=I2AQ6FwpSrc https://m.youtube.com/watch?v=I2AQ6FwpSrc Anyways, in all seriousness the idea of taking something and then taking something else later to counteract the effects, not good but popular in black, gray, and white market. I think this weekend I’ll give up caffeine, I’m a slow metabolizer.
    - pillefitz 3y ago
      I was thinking more in terms of actual antidote by either binding the active substance or speeding up its metabolism, rather than having two substances acting in opposing directions. Anyway, I gave up caffeine earlier this year and am quite happy with the results. Steady and calm energy, no frantic meandering of thoughts, no clinging to details anymore. Once every few weeks I'm craving the euphoric buzz and drink half an Espresso, but typically regret it later the same day as I'm unable to sleep and, interestingly, tend to wake up in the middle of the night for a couple of days after.
  - amelius 3y ago
    > If only there was a short-acting stimulant and antidote available as a combo.. I know that energy drinks use taurine to combat some of the effects of caffeine, but I don't think it will work for sleep.
- deleted 3y ago
  [deleted]
fjfuvucucuc 3y ago
And age. I used to do this fine in my 20s. 30s not so much.
growingkittens 3y ago
Or by having ADHD - coffee before bed can give me just enough focus to fall asleep.

Lewton 3y ago

2pm might not be early enough. Depending on genetics the half life of caffeine in your system can vary by a lot. Even if you're in the normal range, a half life of 4-6 hours means that ~25% of the caffeine would still be in your system by midnight... If you're that worried about sleep quality, it's baffling you have not tried cutting out caffeine altogether

garrickvanburen 3y ago
No caffeine after 10am here.
- balfirevic 3y ago
  None of the statements "no coffee after XX" make sense without specifying when you go to sleep.
  - garrickvanburen 3y ago
    I’m not sure the marginal difference between say 8p and midnight is material with a 10a cutoff.

RoyalHenOil 3y ago

For me, caffeine aids sleep. I find it much easier to make myself stop excessively thinking about things when I am caffeinated. However, if I have caffeine too early in the day, it makes it harder to clear my mind and sleep that night than if I had no caffeine at all. For this reason, I aim to only have caffeine after 3pm (preferably later, depending on when I plan to go to bed).