And don't forget thalidomide! It was initially marketed for anxiety, sleeplessness, and morning sickness over in Europe. This led to a massive amount of birth

And don't forget thalidomide! It was initially marketed for anxiety, sleeplessness, and morning sickness over in Europe. This led to a massive amount of birth defects and newborn fatalities. Luckily the FDA did not approve it. The FDA reviewer was early in her career and was essentially given thalidomide to look over as an "easy start", but luckily she had an interest in fetal development and refused to approve it until fetal interactions were shown to be safe. It resulted in a huge battle with the manufacturer which was only resolved by it being linked to birth defects in the rest of the world - after which they withdrew their application.