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Since the 1970s Caries vaccine (https://en.wikipedia.org/wiki/Caries_vaccine https://en.wikipedia.org/wiki/Caries_vaccine) has been under development. Streptoco
by downvotetruth 3y ago
Since the 1970s Caries vaccine (https://en.wikipedia.org/wiki/Caries_vaccine https://en.wikipedia.org/wiki/Caries_vaccine) has been under development. Streptococcus mutans was modified in the 2000s to not produce acid (BCS3-L1) with the hope to end cavities, gingivitis, etc., but has seemingly disappeared maybe to reappear in 2033 when the patent expires. Hope to be able to stop brushing teeth before I die or at least still have some left to chew food.
- gymbeaux 3y agoSource? Reminds me of Novamin, which is absent from all toothpastes in the US but not in Europe, Canada, et al
- pests 3y agoI got pretty deep into bioglass a few weeks ago. It's a calcium sodium phosphosilicate that attaches to your teeth and eventually regrows into basically real bone. The mechanism of action is very interesting.
- vlovich123 3y agoIs there a product on the market doing this already?
- salad-tycoon 3y agoDon’t think they are the same thing but there’s HPA toothpaste. I bought some from “Boka.” Guess it’s popular in Japan for some time.
- bayindirh 3y agoIn Europe, there's Sensodyne Promine Repair+. Recently I was eating some dried mulberries and I chewed a stone (it was hidden inside a cluster), rendering two of my teeth sensitive and probably damaged my enamel. Using this for 2.5 months now, and my teeth are neither sensitive, nor I feel that damage anymore. I'll continue a couple of more tubes of this, and It'll be probably completely repaired.
- deleted 3y ago[deleted]
- eecc 3y agoAlso Biorepair, an hydroxyapatite that mimics natural enamel.
- carabiner 3y agoAny specific toothpastes with bioglass that you recommend?
- gymbeaux 3y agoI use the Sensodyne Repair (with Novamin) toothpaste. I've been ordering it from Amazon from a Canadian seller.
- xattt 3y agoI’m mildly nervous to have slightly oversized teeth from Novamin accretion from regular use.
- klipklop 3y agoThanks, going to look into importing this.
- vlovich123 3y agoIsn’t it in Sensodyne, a toothpaste readily available in the US?
- justinc8687 3y agoSensodyne sold in the US doesn't contain novamin.
- 0cf8612b2e1e 3y agoUS version does not contain Novamin/Biomin.
- xvector 3y agoUgh fuck the FDA.
- LeafItAlone 3y agoFrom my read, it sounds more like a problem with GSK. They bought the company that produced it, limited the products it was in to just their Sensodyne line, and have not gone through the process to get it approved. GSK is keeping you from getting the product you want.
- justrealist 3y ago"the process to get it approved" costs billions of dollars. that's the FDA's fault.
- LeafItAlone 3y agoThat’s the estimated cost of developing a new drug and bringing it to market. And GSK had ~$16 billion in _profit_ last year. It has been profitable for the past 15 years, usually in the $4b range. They are choosing to not bring this product to market. They are also choosing to not allow another company bring it to market. That is clearly the best business choice for them according to their accounting, but they aren’t limited in trying to do it.
- esaym 3y agoHoly cow! Talk about a rabbit hole. I am right now on ebay buying a Canadian box!
- pkaye 3y agoBecause it would be regulated as a drug in the US. In other countries its considered a cosmetic which means only safety trials.
- deleted 3y ago[deleted]
- IG_Semmelweiss 3y agoThis is good advice
- deleted 3y ago[deleted]
- thescriptkiddie 3y agoI once had an argument with a guy who thought that fluoride didn't work, because if it did dentists would tell you not to use it. After all, why would they undercut their own business? My counter-argument that dentists just want to help people was met with bemused skepticism, as was my speculation that they probably make more money from routine cleanings than from drilling cavities. I am now fully convinced that the dentist lobby is keeping the caries vaccine from us.
- mike_d 3y agoSetting aside the pros or cons of fluoride from a dental perspective, it sure is incredibly convenient that a highly toxic industrial byproduct that was expensive to dispose of can now just be diluted down and dumped into municipal water systems and mouthwash.
- Timon3 3y agoIs all the fluoride which is produced as a byproduct used in drinking water? If not, why would they try to get rid of a small amount this way?
- Gibbon1 3y agoPeople also claim that tax law is so complicated because accountants want more work. Actual accountants would prefer another hole in their head to more complex tax law. Same people claim the AMA is suppressing cures for cancer cause reasons.
- zarzavat 3y agoThis is somewhat true isn’t it? Doesn’t TurboTax lobby against automatic filing of taxes like we have in the UK? Most people in the UK do not submit tax returns at all, the appropriate amount of tax is simply withheld from their pay.
- Gibbon1 3y agoRentier capitalists will always do stuff like that.
- techdragon 3y agoFreon memory the issue they faced was the FDA not really having a path/category for them to be licensed under. It was a live bacteria “vaccine” with a mechanism of action that basically amounts to “out compete the bad bacteria and stick around forever in the human mouth because the other bacteria would have anyway” … which was a brilliant idea! Between being early on the applied genetic manipulation tech wave, having a product that reproduces itself and sticks around forever (cue the FDAs concern meter rising) and at least in the eyes of the FDA not really fitting into any existing licensable food/drug categories they have established procedures for… the company stalled … and pivoted to selling some kind of water product I think.
- mattmaroon 3y agoMan I’d still brush my teeth even if the threat of cavities was removed in much the same way I shower even though I’d be fine if I didn’t. But I’d still take the vaccine too.
- salad-tycoon 3y agoTechnically, you can stop brushing any time. Forget cavities though, brushing is great to get rid of film and grime and stench. I’ll keep brushing.
- adolph 3y agoSimilar to excessive antibiotic use, the clean feeling may be harmful by disrupting the balance of one’s oral microbiome. The feeling of disgust for natural body odors and biofilms is a product of socialization, in the case of toothpaste the history of marketing is told by Charles Duhig below: But Duhigg argues the brand might not have succeeded if it weren’t for Pepsodent’s unique ingredient list. The inventor “had decided to add a little bit of mint extract. Mint extract, as well as a couple of other ingredients that he added, are irritants. They cause our tongues and our gum to tingle.” And the effect of that tingling? It told people that “the toothpaste was working,” said Duhigg, “even though it had nothing to do with how the toothpaste actually worked. And people began to equate that tingling feeling with good dental hygiene. And as a result they began to crave it.” https://www.marketplace.org/2018/03/16/mouth-full-mint-cleaner-teeth-no-thanks/ https://www.marketplace.org/2018/03/16/mouth-full-mint-clean...
- salad-tycoon 3y agoMaybe it’s my personal mouth biome but if I don’t brush once a day I wake up with a disgusting thick film along the back of my throat and tongue. I’m not ocd about oral health. I have great teeth. I don’t floss and brush once a day. I don’t wear fragrances etc. I work in healthcare and I’ve smelled a lot of really not nice things, bad breathe can really really stink. It’s not a cultural thing it’s more like a “good lord, shut your mouth you smell like you have a pile of MRSA infected shit festival in your mouth” I used to smoke and other things, I have terrible sense of smell except when it comes to festering wounds and/or shit, especially infected shit. I pick those up like a hound dog and I know when someone isn’t brushing pretty quickly. I do believe that mint thing though, I’ve been experimenting with different flavors ginger and orange cream and etc (non minty) and I miss the minty feed back.