3 ms·

> The only intervention I know of that shows robust results preventing Alzheimers is having been recently vaccinated. It doesn't seem to matter much for what, b

> The only intervention I know of that shows robust results preventing Alzheimers is having been recently vaccinated. It doesn't seem to matter much for what, but several population studies, involving tens of thousands of patients and controlling for lifestyle confounders, show a reliable 40% reduction in dementia risk for people recently vaccinated for TDaP. Nobody will talk about it, apparently because it is embarrassing to have no clue why it works. (Pressed, people mumble about inflammation.) And, of course, no money is spent figuring it out, or figuring out why vaccination doesn't seem to help the other 60%. Source? This sounds like a theory I would've seen here before.

EarthMephit 3y ago
This study involved 1.8 million patients: https://www.sciencedaily.com/releases/2022/06/220624123814.htm https://www.sciencedaily.com/releases/2022/06/220624123814.h... > People who received at least one influenza vaccine were 40% less likely than their non-vaccinated peers to develop Alzheimer's disease over the course of four years, according to a new study from UTHealth Houston.
- copperx 3y ago
  I've heard about this effect with TDAP and the Shingles vaccine. I wonder what's the mechanism.
- angiosperm 3y ago
  Wow, thanks, I didn't know about this one. Going from tracking 60,000 patients in 2020 to 1,872,000 patients in 2022 is quite a jump in robustness. This one tracked people vaccinated against flu every year, instead of (just?) TDaP. People vaccinated every year did better than those vaccinated fewer years, with the same 40% effect size. I wonder how many million people they will need to demonstrate the effect in, before any of the the mouse beta-amylase grant money gets diverted to figuring out how vaccines forestall it, and how many before any GPs start applying the (embarrassing) results. Sci-hub doesn't have the paper, but it seems to be open-access: https://content.iospress.com/download/journal-of-alzheimers-disease/jad220361?id=journal-of-alzheimers-disease%2Fjad220361 https://content.iospress.com/download/journal-of-alzheimers-...

EarthMephit 3y ago

This study involved 1.8 million patients: https://www.sciencedaily.com/releases/2022/06/220624123814.htm https://www.sciencedaily.com/releases/2022/06/220624123814.h... > People who received at least one influenza vaccine were 40% less likely than their non-vaccinated peers to develop Alzheimer's disease over the course of four years, according to a new study from UTHealth Houston.

copperx 3y ago
I've heard about this effect with TDAP and the Shingles vaccine. I wonder what's the mechanism.
angiosperm 3y ago
Wow, thanks, I didn't know about this one. Going from tracking 60,000 patients in 2020 to 1,872,000 patients in 2022 is quite a jump in robustness. This one tracked people vaccinated against flu every year, instead of (just?) TDaP. People vaccinated every year did better than those vaccinated fewer years, with the same 40% effect size. I wonder how many million people they will need to demonstrate the effect in, before any of the the mouse beta-amylase grant money gets diverted to figuring out how vaccines forestall it, and how many before any GPs start applying the (embarrassing) results. Sci-hub doesn't have the paper, but it seems to be open-access: https://content.iospress.com/download/journal-of-alzheimers-disease/jad220361?id=journal-of-alzheimers-disease%2Fjad220361 https://content.iospress.com/download/journal-of-alzheimers-...