6 ms·
What is a current effective way of getting CoQ10 in the system?
by culopatin 3y ago
What is a current effective way of getting CoQ10 in the system?
- K0balt 3y agoThere are supplement formulations that are supposed to improve absorption, but I don’t know of their efficacy. AFAIK heavy front end loading is the only current option and may have limited effectiveness, although empirically I can say that supplementation appears to reduce markers of oxidative stress in my bloodstream and is similar but less effective for my brother, and it seemed effective for my father. I have a suspicion that absorption might have a genetic component or may be dependant on other lifestyle factors, or perhaps dependant upon the generation mechanisms for oxidative stress itself. IOTW YMMV and I’m not sure if supplemental CoQ10 is effective for everyone. It does seem to be safe, though, so there’s that.
- wyldfire 3y agoAre there any dietary sources that are CoQ<N>-rich?
- K0balt 3y agoI’m sure there are, but I lean on supplements because I’m lazy.
- jbotz 3y agoAnimal organ meats, especially hearts, have the highest level of CoQ10 of any common dietary sources. I suspect quite a few common modern dietary deficiences are the result most people no longer eating the "whole animal".
- neeleshs 3y agoAny brand recommendations?
- K0balt 3y agoI have no reason to believe that one brand is categorically better than another so I typically buy from someplace like puritans pride because of cost. Seems to work. From the website it’s cheaper than if you buy from their Amazon store. But I wouldn’t call this a recommendation, more if a report of my choice and my reasoning. I’m sure there are “better” options, but I don’t care if I have to ingest 200 mg of one brand to get the benefit I would get from 100mg of another brand, for 4x the price. In all I’d rather buy from a source that moves a lot of production and is less likely to be counterfeited or suffer from production inconsistencies. But that’s just like, my unfounded and poorly considered opinion so…
- cosmojg 3y agoI've had great experiences with Nootropics Depot in terms of both product purity and customer service.
- zer8k 3y agoSolgar has been my go-to for a long time.
- ar-jan 3y agoI'll second the recommendation for Nootropics Depot. They're top notch with regard to testing (they run an ISO 17025 accreddited lab), and the owner frequently talks about the science of how various compounds work and interact on r/NootropicsDepot.
- Aurornis 3y agoOral supplementation has low efficiency, but taking higher doses can compensate. There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive formulation. CoQ10 supplementation has resulted in insomnia for some. I triggered it with higher doses (600-900mg per day) before I realized what was happening. Dropping down to 300mg alleviated the insomnia after about a week, which I interpreted as meaning the supplement was doing something.
- sufehmi 3y agoOne question - in your case, how long does it take for you to start noticing its (good or bad) effect? I've suffered from Longcovid since last year, and this seems to be something safe that I can try, with a possibility of positive result.
- loa_in_ 3y agoIt's as long as it takes to be sure it's not other things that inadvertently happen to one in life
- dmix 3y agoI've bought a bunch of stuff of Bryan Johnsons supplement list (a reasonable amount, 8-9/day) and he recommends 100mg, not sure if he's researched that one properly but he's usually pretty open about it https://blueprint.bryanjohnson.co/#step-2-supplements https://blueprint.bryanjohnson.co/#step-2-supplements I will try 200-300mg instead
- ck2 3y agoubiquinol is the reduced "active" form of coq10 ubiquinone and while ubiquinol can be much more expensive, studies seem to indicate in people older or ill where nutrition absorption may be far less than ideal, the "active" form is absorbed better But like all FUD in the supplement industry, you do not need mega doses
- darkclouds 3y ago[flagged]
- bluefinity 3y agoNice conspiracy theory, but there is no declared upper limit on vitamin K.
- darkclouds 3y agoI never said there was an "upper limit" just that an RDA in microgram amounts exists, still none the less an insightful comment.
- salad-tycoon 3y agoI love conspiracy theories and conspiracy facts but I doubt that it’s big surgery lobby not wanting people to be more clotty. Bad Blood clots aren’t that uncommon, at all. Can be dangerous or not but they not rare by any means. I’m also not convinced on your mega dose theory. That said, wanted to share that super glue was used in Vietnam War to close wounds. Also dermabond RX is krazy glue [1]. Also, this month I’ve caught and killed 12 raccoons. Not sure if you have them over there but they are vile disgusting disease vectors but very cute looking. 1 https://abcnews.go.com/Health/story?id=118175&page=1 https://abcnews.go.com/Health/story?id=118175&page=1
- darkclouds 3y ago> I love conspiracy theories and conspiracy facts but I doubt that it’s big surgery lobby not wanting people to be more clotty. View it however you like, the saying "you can lead a horse to water, but you cant make it drink" springs to mind, but do these two aforementioned chemicals only do blood clotting, or do they take part in other chemical reactions which may be good or bad for human health? > Also, this month I’ve caught and killed 12 raccoons. Not sure if you have them over there but they are vile disgusting disease vectors Dont know if you noticed but living on an island has meant alot of the dangerous animals and vectors were eradicated hundreds of years ago in the UK, and yet in a schadenfreude like manner, the UK and royals like Prince Philip and King Charles attempt to lead the world in animal conservation elsewhere in the world. The Frenchie called William The Conqueror had his uses! That must annoy the Aussies amongst others, considering how many dangerous animals they have over there, but they do put up a good Monty Python Black Knight attitude to the situation. https://www.youtube.com/watch?v=SI5nL8vZcl8 https://www.youtube.com/watch?v=SI5nL8vZcl8
- canucker2016 3y agoexcerpts from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278738/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278738/ Most of the body’s daily requirement for CoQ10 is produced within the body. Some CoQ10 is ingested from food (typically 5 mg/day [5]). It is estimated that the daily requirement for CoQ10, from both endogenous bio-synthesis and food sources, is about 500 mg; this estimate is based on a total body quantity of about 2 mg of CoQ10 and based on an average turnover time of 4 days in tissue [5]. This estimate serves as the justification for the size of the dosage (typically 300 mg/day) that is used in many clinical trial studies. As people mature into adulthood and begin to increase in age, the ability of the body to synthesise its own CoQ10 decreases; optimal human bio-synthesis occurs in the mid-twenties, with a continual gradual decline in tissue levels thereafter [6]. In addition to the normal aging process, CoQ10 levels have also been shown to be depleted in a number of disorders, particularly heart disease [7]. The synthesis of CoQ10 is a complex multistage process (governed by at least 13 genes), requiring a number of amino acids, vitamins, and trace element precursors and cofactors, deficiency of any of which can adversely affect normal CoQ10 production [8]. Nutritional supplementation with CoQ10 therefore provides a mechanism to maintain adequate levels within the body. ...The CoQ10 raw material comes in the structural form of polymorphic crystals [9]. CoQ10 in polymorphic crystalline forms will not be absorbed in the gastro-intestinal tract. CoQ10 can be absorbed only as individual molecules, as described in Section 4 of this article below [10]. The CoQ10 crystals must therefore be dissociated first into individual CoQ10 molecules. ...The first point of note is the difference in bioavailability between samples 01 and 02 of the study. Both samples contained 100 mg CoQ10 in identical ubiquinone form, in a soy carrier oil with identical excipient content and capsule specification; sample 01 (Myoqinon, Pharma Nord, Vejle, Denmark) had been subject to a patented thermal crystal dispersion process whilst sample 02 (from the same manufacturer) had not undergone this procedure. The respective mean AUC and Cmax values in the Lopez-Lluch study were 28.0 mg/L/48 h and 1.07 mg/L for sample 01, and 6.89 mg/L/48 h and 0.33 mg/L for sample 2. Failure to subject crystalline CoQ10 to crystal dispersion therefore reduced bioavailability by approximately 75%. ...Thus, the AUC for CoQ10 in ubiquinol form was approximately twice of that for ubiquinone, which had not been subjected to thermal crystal dispersion (sample 02), but was only 52% of that for ubiquinone that had been subjected to thermal crystal dispersion (sample 01). It should be noted that it is not possible to subject ubiquinol to the same crystal dispersion process as that described for sample 01; this is because of the differential stability of ubiquinone and ubiquinol. These data therefore demonstrate (i) the importance of CoQ10 crystal dispersion, the absence of which reduces bioavailability by some 75%; (ii) the fact that the relative bioavailability of ubiquinone and ubiquinol forms of CoQ10 depends on CoQ10 crystal dispersion status and carrier oil/excipient composition. ... The study therefore concluded that intestinal absorption of CoQ10 is highly variable among individuals, and is independent of the form of CoQ10 (ubiquinone/ubiquinol) administered. This is because the body is limited in how much CoQ10 it can absorb at a given time, and thus if an individual takes several 100 mg capsules together, some of the CoQ10 tends to be wasted CoQ10 is a lipid soluble substance; therefore, the highest quality CoQ10 preparations have the CoQ10 dissolved in a well-suited carrier lipid (e.g., soy oil or palm oil). The KISEL-10 study was a clinical trial that enrolled 443 senior citizens living in south-eastern Sweden. The study was designed as a randomized, double-blind, placebo-controlled clinical trial. The elderly study participants—average age of 78 years—took either 200 milligrams of coenzyme Q10 together with 200 micrograms of an organic high-selenium yeast preparation or matching placebos daily for 4 years The cardio-protective effect of the combined daily supplementation with CoQ10 and selenium endure for several years beyond the period of intervention. A follow-up analysis showed that the significantly reduced risk of death from heart disease still held 12 years after the intervention
- pmlamotte 3y agoIn addition to the typical forms, there's also the synthetic analog idebenone. Obtaining it these days in an oral form is a bit harder though. https://en.wikipedia.org/wiki/Idebenone https://en.wikipedia.org/wiki/Idebenone https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913973/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913973/
- dmix 3y agoInteresting is there a connection between Quinone and CoQ10?