5 ms·

GDF15 is a gene that is activated by NSAIDs. So avoiding them would be a good place to start. https://www.uniprot.org/uniprotkb/Q99988/entry https://www.unipr

GDF15 is a gene that is activated by NSAIDs. So avoiding them would be a good place to start. https://www.uniprot.org/uniprotkb/Q99988/entry https://www.uniprot.org/uniprotkb/Q99988/entry https://www.sciencedirect.com/science/article/abs/pii/S0163725819300282#:~:text=Growth%20Differentiation%20Factor%2015%20(GDF15)%2C%20also%20known%20as%20NSAID,as%20a%20mature%20dimer%20GDF15 https://www.sciencedirect.com/science/article/abs/pii/S01637.... Is also causes insulin release. But NSAIDs have been linked to dementia in the past, so… https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690966/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690966/ it would be pretty crazy if drug companies were causing all of the dementia and Alzheimer’s, wouldn’t it?

Supermancho 3y ago
> it would be pretty crazy if drug companies were causing all of the dementia and Alzheimer’s, wouldn’t it This makes sense from 10k feet. If you perennially treat conditions in the body to reduce symptoms, but the conditions persist, aren't you just masking the inflammation/trauma that accumulates? Perhaps this is the best we can do for the human condition, with current technology.
- FollowingTheDao 3y ago
  I agree that the modality of treating symptoms and not curing disease is probably causing more problems then just having the disease. I disagree that it is the best we can do. I have essentially cured my self of an "incurable" disease, one which was treated with drugs that masked the symptoms while my nervous system kept collapsing. when doctors see my labs and I tell them my story they are uninterested. That has nothing to do with technology and everything to do with curiosity and compassion. My mother was told to take a baby aspirin everyday for her heart. Then the doctor one day to her just to stop taking them. It turns out that "just stopping" casued her to have a mini stroke (TIAs) which was well known issue when stopping long term low dose aspirin. That, and the fact that psychiatrists killed my nephew with medications, has led me to truths about the medical and pharmaceutical industries that see them as an obstacle to human health.
  - Supermancho 3y ago
    I happen to have been taking a blood thinner since I was 9 (almost 40 years now) due to a congenital defect and then the ongoing surgeries. I am aware of the evils of US pharma. Perhaps "the best we can do" was flippant. Apologies.
- criddell 3y ago
  There are a lot of conditions for which treatment of symptoms is really the only option. I take ibuprofen and tylenol fairly frequently to deal with cluster headaches. If anybody can recommend a different course of action, I'm all ears. Dementia terrifies me. My dad died last year with Lewy Body Dementia. After witnessing this, I totally understand why Robin Williams decided to end his life.
  - berdon 3y ago
    Have you tried diltiazem for cluster headaches? I got them after coming off of the medicine for heart related issues. Started taking it again and they vanished.
    - criddell 3y ago
      Nope, but I’ll look into it. Thanks!
  - bebopfunk 3y ago
    This supplement stack + oxygen + verapamil + magic mushrooms has turned clusters into almost a non issue for me. I went through several years of being too broke to really address them, and too pig headed to think something as simple as vitamin D would help. But my last set of clusters was a walk in the park compared to the ones before it. https://web.archive.org/web/20210119212133/https://vitamindwiki.com/Cluster+headaches+substantially+reduced+by+10,000+IU+of+Vitamin+D+in+80+percent+of+people https://web.archive.org/web/20210119212133/https://vitamindw... If you decide to try Verapamil make sure you get the extended release pills. I don’t have the link handy but you can find research journal articles that help nail down dosage. As for the oxygen, you may have to get your own regulator and mask to get what you need. 15lpm and a rebreather mask works amazingly for me. If your doctor is difficult about it just get them to write a script for oxygen, find a local supplier and pay out of pocket. It was only $80 to rent the tanks I needed to get me through my last cluster season. A couple of home remedies I’ve tested and found effective were cardio and putting my feet in some super hot water. Both sound silly but seem to work in my experience. So if you don’t have the other stuff yet, or aren’t able to get to it in time, give either a try. I do burpees as soon as I feel one coming one (and after I’ve chugged a 5 hour energy). The last and most effective solution is LSD or Magic mushrooms. If you micro dose then periodically you can go a lot longer between cluster headaches. A tiny bit of mushroom also seems to work as an abortive for me when I feel one coming on. I’m still experimenting and learning. But hopefully this info may give you some things to research or try (assuming you haven’t already, but I’d much rather share this information repetitively then not share something that could help you). Feel free to reach out if you ever want to chat. Always down to provide research I’ve found out just lend an ear, I know how debilitating and isolating they can be.

Supermancho 3y ago

> it would be pretty crazy if drug companies were causing all of the dementia and Alzheimer’s, wouldn’t it This makes sense from 10k feet. If you perennially treat conditions in the body to reduce symptoms, but the conditions persist, aren't you just masking the inflammation/trauma that accumulates? Perhaps this is the best we can do for the human condition, with current technology.

FollowingTheDao 3y ago
I agree that the modality of treating symptoms and not curing disease is probably causing more problems then just having the disease. I disagree that it is the best we can do. I have essentially cured my self of an "incurable" disease, one which was treated with drugs that masked the symptoms while my nervous system kept collapsing. when doctors see my labs and I tell them my story they are uninterested. That has nothing to do with technology and everything to do with curiosity and compassion. My mother was told to take a baby aspirin everyday for her heart. Then the doctor one day to her just to stop taking them. It turns out that "just stopping" casued her to have a mini stroke (TIAs) which was well known issue when stopping long term low dose aspirin. That, and the fact that psychiatrists killed my nephew with medications, has led me to truths about the medical and pharmaceutical industries that see them as an obstacle to human health.
- Supermancho 3y ago
  I happen to have been taking a blood thinner since I was 9 (almost 40 years now) due to a congenital defect and then the ongoing surgeries. I am aware of the evils of US pharma. Perhaps "the best we can do" was flippant. Apologies.
criddell 3y ago
There are a lot of conditions for which treatment of symptoms is really the only option. I take ibuprofen and tylenol fairly frequently to deal with cluster headaches. If anybody can recommend a different course of action, I'm all ears. Dementia terrifies me. My dad died last year with Lewy Body Dementia. After witnessing this, I totally understand why Robin Williams decided to end his life.
- berdon 3y ago
  Have you tried diltiazem for cluster headaches? I got them after coming off of the medicine for heart related issues. Started taking it again and they vanished.
  - criddell 3y ago
    Nope, but I’ll look into it. Thanks!
- bebopfunk 3y ago
  This supplement stack + oxygen + verapamil + magic mushrooms has turned clusters into almost a non issue for me. I went through several years of being too broke to really address them, and too pig headed to think something as simple as vitamin D would help. But my last set of clusters was a walk in the park compared to the ones before it. https://web.archive.org/web/20210119212133/https://vitamindwiki.com/Cluster+headaches+substantially+reduced+by+10,000+IU+of+Vitamin+D+in+80+percent+of+people https://web.archive.org/web/20210119212133/https://vitamindw... If you decide to try Verapamil make sure you get the extended release pills. I don’t have the link handy but you can find research journal articles that help nail down dosage. As for the oxygen, you may have to get your own regulator and mask to get what you need. 15lpm and a rebreather mask works amazingly for me. If your doctor is difficult about it just get them to write a script for oxygen, find a local supplier and pay out of pocket. It was only $80 to rent the tanks I needed to get me through my last cluster season. A couple of home remedies I’ve tested and found effective were cardio and putting my feet in some super hot water. Both sound silly but seem to work in my experience. So if you don’t have the other stuff yet, or aren’t able to get to it in time, give either a try. I do burpees as soon as I feel one coming one (and after I’ve chugged a 5 hour energy). The last and most effective solution is LSD or Magic mushrooms. If you micro dose then periodically you can go a lot longer between cluster headaches. A tiny bit of mushroom also seems to work as an abortive for me when I feel one coming on. I’m still experimenting and learning. But hopefully this info may give you some things to research or try (assuming you haven’t already, but I’d much rather share this information repetitively then not share something that could help you). Feel free to reach out if you ever want to chat. Always down to provide research I’ve found out just lend an ear, I know how debilitating and isolating they can be.