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Aspartame is a proven contributing factor of insulin resistance development. And you will get it even faster with aspartame than with sucrose. (Sucrose is a fan

Aspartame is a proven contributing factor of insulin resistance development. And you will get it even faster with aspartame than with sucrose. (Sucrose is a fancy but precise name of the usual sugar) Even high fructose corn syrup is better than aspartame when it comes to long-term health consequences. So, consider to avoid aspartame like a plague. If you are into soda than you may find stevia-based formulations which have no side effects.

indymike 3y ago
I'd love to see a citation for this. I've seen a lot of literature saying "it might" but nothing that is conclusive. As a type II diabetic, this matters a lot to me. If there were a link between aspartame and type ii (insulin resistant diabetes) the lawsuits would make asbestos look like small claims.
- garganzol 3y ago
  If you experience adverse effects of T2DM like neuropathy, you may find that symptoms worsen after the intake of a diet coke with aspartame. But if you are not on the edge yet, you will feel nothing extraordinal.
  - Dylan16807 3y ago
    That's not a citation, that's even more claims that need backing.
    - garganzol 3y ago
      There is a cause and effect, and they always have a relation. If aspartame worsens insulin sensitivity by increasing insulin resistance [1] then this will eventually lead to neuropathy [2]. This is a simple logical chain to follow, but I understand that not everybody is made for it. But the real drama occurs when a person finally hits T2DM and starts to develop dementia. Only then they will start to learn, listen and study medicine (maybe), but for the most part it is already too late. See, in this condition, the brain suffers from tissue hypoxia, so the individual has dim chances of properly doing their medical homework, if any work at all. And they won't get a proper help at the usual clinic outside of palliative care, unless they go to a place specializing in neuroendocrinology which is often a cost-prohibiting option not available to everyone. I know, the link between T2DM and dementia may come as surprise to you as well, so here is a citation [3]. "But it's only affecting older people, I'm fine!" - wrong. It affects anyone but the incidence rate is indeed correlated with age. But before all that happens, one can enjoy one more cup of a thirst quincher with aspartame, of course! All those mad naysayers suck, you know. [1] https://pubmed.ncbi.nlm.nih.gov/28571543/#:~:text=Result%3A%20Aspartame%20may%20act%20as,in%20insulin%20deficiency%20or%20resistance https://pubmed.ncbi.nlm.nih.gov/28571543/#:~:text=Result%3A%.... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359792/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359792/ [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052006/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052006/
      - indymike 3y ago
        > But before all that happens, one can enjoy one more cup of a thirst quincher with aspartame, of course! All those mad naysayers suck, you know. I suspect the real issue with aspartame is people drinking two 82oz ultra big gulps a day.
      - Dylan16807 3y ago
        If it worsens insulin sensitivity in a significant way, but that's not established in your links. And you claim that symptoms will often worsen after a drink, right? That sounds like an aggressive effect that would be super easy to test.
- dwaite 3y ago
  I've only seen correlation, not causation. Which makes sense; you likely don't start off drinking Diet Coke - you switch to it once you have some sort of health concern. FWIW, there are studies that a low calorie, low carbohydrate diet can reverse type ii diabetes (or rather, put it in remission)[0]. The underlying hypothesis came about I believe to explain why people who had a gastric reduction surgery would also sometimes see a remission in their diabetes. I use a telemedicine[1] which was involved in one of these studies, and which I believe has started to see some insurance coverage because of the savings related to reduction in insulin used by patients. I'm personally maintaining pre-diabetic levels (but have never used insulin). 0: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1002/doi2.00003 https://dom-pubs.onlinelibrary.wiley.com/doi/10.1002/doi2.00... 1: https://www.virtahealth.com https://www.virtahealth.com
ClassyJacket 3y ago
I don't believe this is true. If it is, provide a source. It is absolutely a lie that corn syrup is better for you than aspartame. That is absolutely 100% false.
- garganzol 3y ago
  Corn syrup "only" causes non-alcoholic fatty liver disease, while aspartame has a potential to cause a systemic oxidative stress. Both conditions contribute to insulin resistance development, but systemic oxidative stress is more dangerous in my book because it leads to more immediate neurological and cardiovascular complications. Don't get me wrong, both ingredients are terrible for one's health, and they both seem to cause similar defects in varying proportions with lots of intersections. If the question is what ingredient degrades health faster, then I have no answer. A few control groups, anyone?

indymike 3y ago

I'd love to see a citation for this. I've seen a lot of literature saying "it might" but nothing that is conclusive. As a type II diabetic, this matters a lot to me. If there were a link between aspartame and type ii (insulin resistant diabetes) the lawsuits would make asbestos look like small claims.

garganzol 3y ago
If you experience adverse effects of T2DM like neuropathy, you may find that symptoms worsen after the intake of a diet coke with aspartame. But if you are not on the edge yet, you will feel nothing extraordinal.
- Dylan16807 3y ago
  That's not a citation, that's even more claims that need backing.
  - garganzol 3y ago
    There is a cause and effect, and they always have a relation. If aspartame worsens insulin sensitivity by increasing insulin resistance [1] then this will eventually lead to neuropathy [2]. This is a simple logical chain to follow, but I understand that not everybody is made for it. But the real drama occurs when a person finally hits T2DM and starts to develop dementia. Only then they will start to learn, listen and study medicine (maybe), but for the most part it is already too late. See, in this condition, the brain suffers from tissue hypoxia, so the individual has dim chances of properly doing their medical homework, if any work at all. And they won't get a proper help at the usual clinic outside of palliative care, unless they go to a place specializing in neuroendocrinology which is often a cost-prohibiting option not available to everyone. I know, the link between T2DM and dementia may come as surprise to you as well, so here is a citation [3]. "But it's only affecting older people, I'm fine!" - wrong. It affects anyone but the incidence rate is indeed correlated with age. But before all that happens, one can enjoy one more cup of a thirst quincher with aspartame, of course! All those mad naysayers suck, you know. [1] https://pubmed.ncbi.nlm.nih.gov/28571543/#:~:text=Result%3A%20Aspartame%20may%20act%20as,in%20insulin%20deficiency%20or%20resistance https://pubmed.ncbi.nlm.nih.gov/28571543/#:~:text=Result%3A%.... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359792/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359792/ [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052006/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052006/
    - indymike 3y ago
      > But before all that happens, one can enjoy one more cup of a thirst quincher with aspartame, of course! All those mad naysayers suck, you know. I suspect the real issue with aspartame is people drinking two 82oz ultra big gulps a day.
    - Dylan16807 3y ago
      If it worsens insulin sensitivity in a significant way, but that's not established in your links. And you claim that symptoms will often worsen after a drink, right? That sounds like an aggressive effect that would be super easy to test.
dwaite 3y ago
I've only seen correlation, not causation. Which makes sense; you likely don't start off drinking Diet Coke - you switch to it once you have some sort of health concern. FWIW, there are studies that a low calorie, low carbohydrate diet can reverse type ii diabetes (or rather, put it in remission)[0]. The underlying hypothesis came about I believe to explain why people who had a gastric reduction surgery would also sometimes see a remission in their diabetes. I use a telemedicine[1] which was involved in one of these studies, and which I believe has started to see some insurance coverage because of the savings related to reduction in insulin used by patients. I'm personally maintaining pre-diabetic levels (but have never used insulin). 0: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1002/doi2.00003 https://dom-pubs.onlinelibrary.wiley.com/doi/10.1002/doi2.00... 1: https://www.virtahealth.com https://www.virtahealth.com

ClassyJacket 3y ago

I don't believe this is true. If it is, provide a source. It is absolutely a lie that corn syrup is better for you than aspartame. That is absolutely 100% false.

garganzol 3y ago
Corn syrup "only" causes non-alcoholic fatty liver disease, while aspartame has a potential to cause a systemic oxidative stress. Both conditions contribute to insulin resistance development, but systemic oxidative stress is more dangerous in my book because it leads to more immediate neurological and cardiovascular complications. Don't get me wrong, both ingredients are terrible for one's health, and they both seem to cause similar defects in varying proportions with lots of intersections. If the question is what ingredient degrades health faster, then I have no answer. A few control groups, anyone?