8 ms·

Don't get your hopes up, and keep brushing your teeth: "The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital

by tgv 3y ago

Don't get your hopes up, and keep brushing your teeth: "The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital factors (anodontia)". There is a vague hope to develop it so that people who lose teeth can use it to regrow, but that seems to be another ball game.

water-data-dude 3y ago
Bummer, I was hoping for shark teeth powers
- deleted 3y ago
  [deleted]
- Tagbert 3y ago
  This will give you the regrowth but the teeth will look like shark teeth. That might cause some odd looks and be careful not to bite your tongue. You’ll only be able to do that once! :-)
  - Electricniko 3y ago
    Tongue replacement is already a thing, oddly enough.
    - withinboredom 3y ago
      Ha! I bit off my tongue from falling a pretty good height. My knee came up and hit my chin, forcibly closing my mouth on my screaming face. When I could finally move again (was paralyzed for a bit), and got to the hospital, they just told me to keep my mouth shut. Apparently, your tongue is just a muscle, so it will reattach itself. It was a shitty few weeks, but at least I didn’t break any bones or land on my head.
      - Reason077 3y ago
        Ouch! I did something similar snowboarding in my early 20s. Landed a badly timed jump on to hard, flat snow and slammed my knee into my chin. Thankfully did not catch my tongue, but shattered several teeth! I remember wondering how I’d ended up with a mouthful of sand and grit. It wasn’t sand.
        ClumsyPilot 3y ago
        > Thankfully did not catch my tongue, but shattered several teeth! Not sure whats worse.
      - codethief 3y ago
        > Apparently, your tongue is just a muscle, so it will reattach itself. Wait, what? Could you elaborate? How does that work?
        withinboredom 3y ago
        I couldn’t move my tongue for a few days (to let it reattach) then it was painful for a few more days, then some of it turned white and rotted off over a few weeks. But other than some gnarly teeth shaped scars, it works and functions like a normal tongue after 20 years. Carrying around a note explaining why I couldn’t talk was also entertaining.
      - Tagbert 3y ago
        Yes, my stepmother did that when she was young. Not sure what they did for it but when I met her she had a weird flap of tongue that could flip forward. That part never reattached. It was disturbing and fascinating to 10 year old me.
  - ooterness 3y ago
    I'm fine with this.
- minibrusp163 3y ago
  [flagged]
pengaru 3y ago
I get the impression that they're targeting the easy case first since stimulating tooth growth there is causing what was supposed to happen anyways, with less likelihood of conflict with the existing teeth. But the article makes it sound plausible that it'd work for normal adults too in that new tooth growth would occur. It's just unclear how/if they guide that growth to a specific area, or if it has to be wholesale replacement of the set of teeth like losing your baby teeth. Maybe what will happen is once you get to a certain point of dental misery you just get on the medicine blocking USAG-1 and have all the remaining teeth pulled, then wait for the new teeth to grow in...
- fendy3002 3y ago
  CMIIW, but when baby teeth is already grown (appear), the other adult set is actually kept hidden inside, not that it grow. I guess it won't be simply as stimulate teeth growth like nail.
  - lelanthran 3y ago
    > CMIIW, but when baby teeth is already grown (appear), the other adult set is actually kept hidden inside, not that it grow. Yup. See this skull of a child with the adult teeth ready to come out and push the baby teeth out of the way (warning, some people find the image very repulsive, even though it's basically a textbook picture of a skull): https://skeptics.stackexchange.com/questions/9541/is-this-image-about-child-teeth-development-accurate https://skeptics.stackexchange.com/questions/9541/is-this-im...
    - dotnet00 3y ago
      I think it comes off as more repulsive because we're not used to seeing those parts of the skull cut away, putting it in the uncanny valley. What helped me to not be as repulsed by it was realizing that those parts of the skull aren't meant to be "uncovered" to show the adult teeth in the first place.
    - toyg 3y ago
      The human body is so amazing... It evolved to ship ready-made replacement parts to ensure the product would complete its deployment (reaching puberty and reproducing for a decade or two).
pessimizer 3y ago
> for people who lack a full set of adult teeth due to congenital factors (anodontia) I've got this, and 1% of people have this. I'd have to imagine that most of them would have obliterated the spot where they could grow these hypothetical new teeth by getting implants, though. So, I'd even think that it's really a treatment for children. When I was a small child, it was already absolutely certain that I wasn't ever going to get my lateral incisors.
- bch 3y ago
  I’ve had “Maryland Bridges” in mine for years (apparently longer than the bridges are typically expected to last (?)), so there are some of us adults around… But sadly for me: Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia.
- MauroIksem 3y ago
  [flagged]
- cmrdporcupine 3y ago
  So my son is like this. Missing a whole bunch of teeth, they'll never come in. Now the question is... wait for this? Or just get implants. He's already way past this 2-6 age range, too :-( Tough.
  - dzdt 3y ago
    This is at way to early a stage to plan around. It is just reaching human safety trials, which is the very earliest part of human trials looking solely for adverse effects. Even in the best possible scenario it would be many years still before this might be available as a treatment. Most drugs which reach this phase of development do not ever become available as a treatment.
  - jopsen 3y ago
    What is the downside to implants? Just curious.
- 3y ago
swayvil 3y ago
I have a friend with notoothia. Only in one tooth tho. And ya, it's weird looking. She got an implant. One of those titanium screws. It works but the gum is weird and the tooth is missized. Would she switch it for a grown tooth given the option? I dunno.
mnau 3y ago
Certain-not-to-be-named-due-to-spam-filter-medicament-on-V was intended for heart related chest pain. My wallet doesn't ask for who it was intended. It asks: Will it work and can I buy it?
- Y_Y 3y ago
  You've just got to format it as an email address: vi@g.ra
dghughes 3y ago
I have GERD and the only reason I found out was my dentist told me. It was because my teeth became so sensitive a room temperature banana was too cold. Lots of pain and still. It's from coughing due to acid reflux and acid splash up onto my teeth. It can also get into my lungs and over time damage them too by causing scarring.
- manmal 3y ago
  Did you have no idea at all, as in, you never felt heartburn in the evening? I wonder if eating the last meal at eg 4PM wouldn’t improve this considerably.
  - withinboredom 3y ago
    As someone else who has some serious GERD, no, you don’t really notice. It’s like boiling a frog (unless you get an acute version). You just suddenly realize: hey, I seem to be having heartburn all the time, I don’t remember it being like this… maybe I should go to the doc? And then you’re fine for a few days and put it off. And no, eating at different times won’t magically make your sphincter to your stomach close any tighter.
    - manmal 3y ago
      > eating at different times won’t magically make your sphincter to your stomach close any tighter Stomach acid is also produced as reaction to food intake and other signals. Less acid => less reflux? BTW probiotics have been found potentially effective by this systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/ This is probably not as simple as blaming the dysfunctional sphincter. IMO early time restricted feeding shouldn’t be dismissed so quickly, it‘s potentially a fix for a number of systemic and gastric/enteric issues. The evidence is still weak but promising. The most important part here is „early“ - intermittent fasting usually has an eating window in the afternoon and maybe right until bed time. According to some (weak) studies, moving the eating window to the morning and early afternoon has vastly different effects.
eikenberry 3y ago
Seems like it shouldn't be referred to as a "regrowth" medicine when you're talking about something that didn't grow in the first place.
- refulgentis 3y ago
  That has a fascinating answer but requires R, no TL;DR from me :)
- deleted 3y ago
  [deleted]
- sigstoat 3y ago
  some newspaper translator had to figure out how to translate the novel(ish?) phrase 歯生え薬. what do you want? it's not like this is FDA-approved marketing materials for something that's actually available.
  - userbinator 3y ago
    It's not exactly difficult: 歯 - tooth 生え - grow 薬 - medicine Doesn't say anything about "regrowth" though.
- MagicMoonlight 3y ago
  It’s talking about growing a third set of teeth so it is regrowth
troft 3y ago
[flagged]
- RajT88 3y ago
  Sharks in general don't need therapy. Their primary problem solving method is biting stuff. As long as those keep growing they can keep solving all of life's problems.
XorNot 3y ago
It does perhaps change the ball game though I would presume - if the goal is to grow a tooth which didn't develop, it changes the requirement to regrow a tooth to just regenerating whatever root structure you need to trigger that (which I would assume is a collection of specialized cells/nerves etc. which you could imagine maybe assembling from stem cells in a scaffold and implanting).
momirlan 3y ago
Once the technology is public, anyone can use it for whatever purpose. Research direction is not the same as commercial application.
abwizz 3y ago
> There is a vague hope to develop it so that people who lose teeth can use it to regrow, but that seems to be another ball game. why does this seem to be another ball game?

by tgv 3y ago

water-data-dude 3y ago

Bummer, I was hoping for shark teeth powers

deleted 3y ago
[deleted]
Tagbert 3y ago
This will give you the regrowth but the teeth will look like shark teeth. That might cause some odd looks and be careful not to bite your tongue. You’ll only be able to do that once! :-)
- Electricniko 3y ago
  Tongue replacement is already a thing, oddly enough.
  - withinboredom 3y ago
    Ha! I bit off my tongue from falling a pretty good height. My knee came up and hit my chin, forcibly closing my mouth on my screaming face. When I could finally move again (was paralyzed for a bit), and got to the hospital, they just told me to keep my mouth shut. Apparently, your tongue is just a muscle, so it will reattach itself. It was a shitty few weeks, but at least I didn’t break any bones or land on my head.
    - Reason077 3y ago
      Ouch! I did something similar snowboarding in my early 20s. Landed a badly timed jump on to hard, flat snow and slammed my knee into my chin. Thankfully did not catch my tongue, but shattered several teeth! I remember wondering how I’d ended up with a mouthful of sand and grit. It wasn’t sand.
      - ClumsyPilot 3y ago
        > Thankfully did not catch my tongue, but shattered several teeth! Not sure whats worse.
    - codethief 3y ago
      > Apparently, your tongue is just a muscle, so it will reattach itself. Wait, what? Could you elaborate? How does that work?
      - withinboredom 3y ago
        I couldn’t move my tongue for a few days (to let it reattach) then it was painful for a few more days, then some of it turned white and rotted off over a few weeks. But other than some gnarly teeth shaped scars, it works and functions like a normal tongue after 20 years. Carrying around a note explaining why I couldn’t talk was also entertaining.
    - Tagbert 3y ago
      Yes, my stepmother did that when she was young. Not sure what they did for it but when I met her she had a weird flap of tongue that could flip forward. That part never reattached. It was disturbing and fascinating to 10 year old me.
- ooterness 3y ago
  I'm fine with this.
minibrusp163 3y ago
[flagged]

pengaru 3y ago

I get the impression that they're targeting the easy case first since stimulating tooth growth there is causing what was supposed to happen anyways, with less likelihood of conflict with the existing teeth. But the article makes it sound plausible that it'd work for normal adults too in that new tooth growth would occur. It's just unclear how/if they guide that growth to a specific area, or if it has to be wholesale replacement of the set of teeth like losing your baby teeth. Maybe what will happen is once you get to a certain point of dental misery you just get on the medicine blocking USAG-1 and have all the remaining teeth pulled, then wait for the new teeth to grow in...

fendy3002 3y ago
CMIIW, but when baby teeth is already grown (appear), the other adult set is actually kept hidden inside, not that it grow. I guess it won't be simply as stimulate teeth growth like nail.
- lelanthran 3y ago
  > CMIIW, but when baby teeth is already grown (appear), the other adult set is actually kept hidden inside, not that it grow. Yup. See this skull of a child with the adult teeth ready to come out and push the baby teeth out of the way (warning, some people find the image very repulsive, even though it's basically a textbook picture of a skull): https://skeptics.stackexchange.com/questions/9541/is-this-image-about-child-teeth-development-accurate https://skeptics.stackexchange.com/questions/9541/is-this-im...
  - dotnet00 3y ago
    I think it comes off as more repulsive because we're not used to seeing those parts of the skull cut away, putting it in the uncanny valley. What helped me to not be as repulsed by it was realizing that those parts of the skull aren't meant to be "uncovered" to show the adult teeth in the first place.
  - toyg 3y ago
    The human body is so amazing... It evolved to ship ready-made replacement parts to ensure the product would complete its deployment (reaching puberty and reproducing for a decade or two).

pessimizer 3y ago

> for people who lack a full set of adult teeth due to congenital factors (anodontia) I've got this, and 1% of people have this. I'd have to imagine that most of them would have obliterated the spot where they could grow these hypothetical new teeth by getting implants, though. So, I'd even think that it's really a treatment for children. When I was a small child, it was already absolutely certain that I wasn't ever going to get my lateral incisors.

bch 3y ago
I’ve had “Maryland Bridges” in mine for years (apparently longer than the bridges are typically expected to last (?)), so there are some of us adults around… But sadly for me: Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia.
MauroIksem 3y ago
[flagged]
cmrdporcupine 3y ago
So my son is like this. Missing a whole bunch of teeth, they'll never come in. Now the question is... wait for this? Or just get implants. He's already way past this 2-6 age range, too :-( Tough.
- dzdt 3y ago
  This is at way to early a stage to plan around. It is just reaching human safety trials, which is the very earliest part of human trials looking solely for adverse effects. Even in the best possible scenario it would be many years still before this might be available as a treatment. Most drugs which reach this phase of development do not ever become available as a treatment.
- jopsen 3y ago
  What is the downside to implants? Just curious.
3y ago

swayvil 3y ago

I have a friend with notoothia. Only in one tooth tho. And ya, it's weird looking. She got an implant. One of those titanium screws. It works but the gum is weird and the tooth is missized. Would she switch it for a grown tooth given the option? I dunno.

mnau 3y ago

Certain-not-to-be-named-due-to-spam-filter-medicament-on-V was intended for heart related chest pain. My wallet doesn't ask for who it was intended. It asks: Will it work and can I buy it?

Y_Y 3y ago
You've just got to format it as an email address: vi@g.ra

dghughes 3y ago

I have GERD and the only reason I found out was my dentist told me. It was because my teeth became so sensitive a room temperature banana was too cold. Lots of pain and still. It's from coughing due to acid reflux and acid splash up onto my teeth. It can also get into my lungs and over time damage them too by causing scarring.

manmal 3y ago
Did you have no idea at all, as in, you never felt heartburn in the evening? I wonder if eating the last meal at eg 4PM wouldn’t improve this considerably.
- withinboredom 3y ago
  As someone else who has some serious GERD, no, you don’t really notice. It’s like boiling a frog (unless you get an acute version). You just suddenly realize: hey, I seem to be having heartburn all the time, I don’t remember it being like this… maybe I should go to the doc? And then you’re fine for a few days and put it off. And no, eating at different times won’t magically make your sphincter to your stomach close any tighter.
  - manmal 3y ago
    > eating at different times won’t magically make your sphincter to your stomach close any tighter Stomach acid is also produced as reaction to food intake and other signals. Less acid => less reflux? BTW probiotics have been found potentially effective by this systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/ This is probably not as simple as blaming the dysfunctional sphincter. IMO early time restricted feeding shouldn’t be dismissed so quickly, it‘s potentially a fix for a number of systemic and gastric/enteric issues. The evidence is still weak but promising. The most important part here is „early“ - intermittent fasting usually has an eating window in the afternoon and maybe right until bed time. According to some (weak) studies, moving the eating window to the morning and early afternoon has vastly different effects.

eikenberry 3y ago

Seems like it shouldn't be referred to as a "regrowth" medicine when you're talking about something that didn't grow in the first place.

refulgentis 3y ago
That has a fascinating answer but requires R, no TL;DR from me :)
deleted 3y ago
[deleted]
sigstoat 3y ago
some newspaper translator had to figure out how to translate the novel(ish?) phrase 歯生え薬. what do you want? it's not like this is FDA-approved marketing materials for something that's actually available.
- userbinator 3y ago
  It's not exactly difficult: 歯 - tooth 生え - grow 薬 - medicine Doesn't say anything about "regrowth" though.
MagicMoonlight 3y ago
It’s talking about growing a third set of teeth so it is regrowth

troft 3y ago

[flagged]

RajT88 3y ago
Sharks in general don't need therapy. Their primary problem solving method is biting stuff. As long as those keep growing they can keep solving all of life's problems.

XorNot 3y ago

It does perhaps change the ball game though I would presume - if the goal is to grow a tooth which didn't develop, it changes the requirement to regrow a tooth to just regenerating whatever root structure you need to trigger that (which I would assume is a collection of specialized cells/nerves etc. which you could imagine maybe assembling from stem cells in a scaffold and implanting).

momirlan 3y ago

Once the technology is public, anyone can use it for whatever purpose. Research direction is not the same as commercial application.

abwizz 3y ago

> There is a vague hope to develop it so that people who lose teeth can use it to regrow, but that seems to be another ball game. why does this seem to be another ball game?