3 ms·

It causes weight loss, sure, but it doesn't seem like it's actually healthy weight loss - it entails disproportionate loss of lean mass and unfavorable metaboli

It causes weight loss, sure, but it doesn't seem like it's actually healthy weight loss - it entails disproportionate loss of lean mass and unfavorable metabolic changes. https://twitter.com/raphaels7/status/1662021374276255746 https://twitter.com/raphaels7/status/1662021374276255746 There are also anecdotes of appetite bouncing back up above the baseline after discontinuation. It's very much so not a magic pill.

anovikov 3y ago
These are not anecdotes, that's a fact and clinical trial doesn't attempt to hide that: you are stuck on those injections for the rest of your days or half the weight returns in about 3 months and nearly all of it, in a year.
hendersoon 3y ago
It is absolutely magical, and I can say based on extensive blood work and a MRI that the changes were extraordinarily beneficial for me, personally. "Unhealthy weight loss" is a stupid phrase. When you're morbidly obese and lose a third of your body weight, your life expectancy changes dramatically. You do need to take it for the rest of your life. But, so what? If you have high blood pressure or cholesterol, you need to take an ACE inhibitor or statin the rest of your life too. These are chronic conditions. Obesity is too.
- Llamamoe 3y ago
  Skeletal muscle is a very, very important organ, and there's way more to health risks of obesity than having too much fat tissue alone. Take PPAR-gamma agonists(Pioglitazone, Rosiglitazone, CBD): They cause weight gain but are one of the most effective diabetes treatments. Why? Because they generate healthy, insulin-sensitive subcutaneous fat and increase the insulin sensitivity of other cells in your body. Saying it doesn't matter how you lose the weight doesn't matter is plain ridiculous. Losing 1kg of visceral fat would be amazing, but 1kg of muscle? That's fucking bad for you. What I see is yet another expensive(profitable) way to manage symptoms while discouraging healthcare as a field from looking for or treating root causes. Not that it's doing much of that as it is.

anovikov 3y ago

These are not anecdotes, that's a fact and clinical trial doesn't attempt to hide that: you are stuck on those injections for the rest of your days or half the weight returns in about 3 months and nearly all of it, in a year.

hendersoon 3y ago

It is absolutely magical, and I can say based on extensive blood work and a MRI that the changes were extraordinarily beneficial for me, personally. "Unhealthy weight loss" is a stupid phrase. When you're morbidly obese and lose a third of your body weight, your life expectancy changes dramatically. You do need to take it for the rest of your life. But, so what? If you have high blood pressure or cholesterol, you need to take an ACE inhibitor or statin the rest of your life too. These are chronic conditions. Obesity is too.

Llamamoe 3y ago
Skeletal muscle is a very, very important organ, and there's way more to health risks of obesity than having too much fat tissue alone. Take PPAR-gamma agonists(Pioglitazone, Rosiglitazone, CBD): They cause weight gain but are one of the most effective diabetes treatments. Why? Because they generate healthy, insulin-sensitive subcutaneous fat and increase the insulin sensitivity of other cells in your body. Saying it doesn't matter how you lose the weight doesn't matter is plain ridiculous. Losing 1kg of visceral fat would be amazing, but 1kg of muscle? That's fucking bad for you. What I see is yet another expensive(profitable) way to manage symptoms while discouraging healthcare as a field from looking for or treating root causes. Not that it's doing much of that as it is.