4 ms·

If Metformin reduces the viral load, it probably does so throughout the entire body. Whereas intramuscular vacccination leads to good protection against serious

If Metformin reduces the viral load, it probably does so throughout the entire body. Whereas intramuscular vacccination leads to good protection against serious disease through humoral (body serum) immunity, it does not, unfortunately, provide significant protection to the other immune compartments like the upper respiratory mucosal layer (served by a different set of antibodies than the humoral). So this is good. This (and paxlovid) can help protect those remaining unprotected tissues of the upper respiratory that tend to be the first infected. It should be a good temporary mitigation until the USA and other countries approve of good intranasal sars-cov-2 vaccine boosters like India has (Innovac).

thatguy0900 3y ago
I honestly can't imagine taking more covid vaccines. I haven't even thought about covid for a year now.
- unsupp0rted 3y ago
  People with long covid have thought about it a lot during the last year
- QuantumGood 3y ago
  Some of us think 7 million dead is a lot, and find it harder to ignore than you do.
  - PraetorianGourd 3y ago
    3.4 million people die every year in the US. What makes these deaths acceptable but COVID a tragedy? And yes, many of those 3.4 million are preventable.
    - QuantumGood 3y ago
      It's fine if you want to make a point about COVID deaths—go ahead and say what you mean to say. I get there are many things to be said. But it's unclear why you're involving my comment with your soapbox. The parent comment to mine was about "not thinking about COVID". Why not just say what you mean to say in full? There is no need to try to put words into someone else's mouth to speak up for what you believe. You seem to simply be re-framing my comment in order to make yours. One way to start is along the lines of "This makes me think of an aspect of [the topic] which is [...] and what I think about that is [...]". (No one brought up or said any of those other deaths were acceptable. Nor did I say that COVID deaths were unacceptable or "tragic".)
      - PraetorianGourd 3y ago
        Your comment itself carried implications. “Some of us think…” is aggressive, and it contrasts the “enlightened” view against others. And you assume that the OP was ignoring those deaths, when they simply said it isn’t at the forefront of their mind. I was contrasting your admonishment of the OP against the millions of deaths that you, presumably, “ignore”. The thesis is, why is it that COVID is hard to ignore while the totality of all other causes of death are more easily ignored? My point was, you and me and everyone ignores deaths to some extent all the time. And you were so sure of your righteousness that you had to reply showing the world how refined and caring you are.
anonymouskimmer 3y ago
> good intranasal sars-cov-2 vaccine boosters I like USSF's Qyndr vaccine candidate, it's an oral one. For mucosal immunity I've read that it doesn't matter whether the vaccine is targeting the upper-respiratory system or the gut.

thatguy0900 3y ago

I honestly can't imagine taking more covid vaccines. I haven't even thought about covid for a year now.

unsupp0rted 3y ago
People with long covid have thought about it a lot during the last year
QuantumGood 3y ago
Some of us think 7 million dead is a lot, and find it harder to ignore than you do.
- PraetorianGourd 3y ago
  3.4 million people die every year in the US. What makes these deaths acceptable but COVID a tragedy? And yes, many of those 3.4 million are preventable.
  - QuantumGood 3y ago
    It's fine if you want to make a point about COVID deaths—go ahead and say what you mean to say. I get there are many things to be said. But it's unclear why you're involving my comment with your soapbox. The parent comment to mine was about "not thinking about COVID". Why not just say what you mean to say in full? There is no need to try to put words into someone else's mouth to speak up for what you believe. You seem to simply be re-framing my comment in order to make yours. One way to start is along the lines of "This makes me think of an aspect of [the topic] which is [...] and what I think about that is [...]". (No one brought up or said any of those other deaths were acceptable. Nor did I say that COVID deaths were unacceptable or "tragic".)
    - PraetorianGourd 3y ago
      Your comment itself carried implications. “Some of us think…” is aggressive, and it contrasts the “enlightened” view against others. And you assume that the OP was ignoring those deaths, when they simply said it isn’t at the forefront of their mind. I was contrasting your admonishment of the OP against the millions of deaths that you, presumably, “ignore”. The thesis is, why is it that COVID is hard to ignore while the totality of all other causes of death are more easily ignored? My point was, you and me and everyone ignores deaths to some extent all the time. And you were so sure of your righteousness that you had to reply showing the world how refined and caring you are.

anonymouskimmer 3y ago

> good intranasal sars-cov-2 vaccine boosters I like USSF's Qyndr vaccine candidate, it's an oral one. For mucosal immunity I've read that it doesn't matter whether the vaccine is targeting the upper-respiratory system or the gut.