4 ms·

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01359-7 https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-triple-therapy.pdf https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

henearkr 3y ago
And, recently discovered too, inflammation-induced neuron mergings.
darkerside 3y ago
Parent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.
- ethanbond 3y ago
  They’re quite clearly saying that the effectiveness of the treatment is actually “the first” solid evidence of the disease. Which is wrong, it’s not the first, but it is also pretty darn good evidence to add to the pile, so it’s not that wrong. It’s just the evidence that appears to have convinced GP, which is cool to see happen in real time!
- hilbertseries 3y ago
  Triple therapy is a treatment that proceeds it. Metformin isn’t a treatment, it’s a prophylactic.
  - darkerside 3y ago
    Yes, a prophylactic treatment. I think my point stands, semantics aside.
    - hilbertseries 3y ago
      It's not the first evidence of treatment and preventing isn't the same as treating, because it does nothing for people who have the disease.
      - darkerside 3y ago
        Can you share prior evidence of effective treatment? It's the first I've heard of it, and obviously the same goes for parent poster. I understand the distinction you are making, and that's why I said semantics aside.
- nradov 3y ago
  I don't know about bacteria, but post viral syndrome has been measured for decades with other viruses. https://pubmed.ncbi.nlm.nih.gov/3320358/ https://pubmed.ncbi.nlm.nih.gov/3320358/ Metformin doesn't have any "magical" anti-aging properties. It is effective for treating certain metabolic conditions such as type-2 diabetes but it has never been proven to extend lifespan in otherwise healthy humans (or any other higher primate). There are some significant negative side effects. https://peterattiamd.com/ama45/ https://peterattiamd.com/ama45/
  - darkerside 3y ago
    I meant the magical part as tongue in cheek. I guess that doesn't come across well in text. My conjecture is that the anecdotal or limited evidence could be conflated with an improvement of latent infections, which would be an inconsistent effect.
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henearkr 3y ago

And, recently discovered too, inflammation-induced neuron mergings.

darkerside 3y ago

Parent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.

ethanbond 3y ago
They’re quite clearly saying that the effectiveness of the treatment is actually “the first” solid evidence of the disease. Which is wrong, it’s not the first, but it is also pretty darn good evidence to add to the pile, so it’s not that wrong. It’s just the evidence that appears to have convinced GP, which is cool to see happen in real time!
hilbertseries 3y ago
Triple therapy is a treatment that proceeds it. Metformin isn’t a treatment, it’s a prophylactic.
- darkerside 3y ago
  Yes, a prophylactic treatment. I think my point stands, semantics aside.
  - hilbertseries 3y ago
    It's not the first evidence of treatment and preventing isn't the same as treating, because it does nothing for people who have the disease.
    - darkerside 3y ago
      Can you share prior evidence of effective treatment? It's the first I've heard of it, and obviously the same goes for parent poster. I understand the distinction you are making, and that's why I said semantics aside.
nradov 3y ago
I don't know about bacteria, but post viral syndrome has been measured for decades with other viruses. https://pubmed.ncbi.nlm.nih.gov/3320358/ https://pubmed.ncbi.nlm.nih.gov/3320358/ Metformin doesn't have any "magical" anti-aging properties. It is effective for treating certain metabolic conditions such as type-2 diabetes but it has never been proven to extend lifespan in otherwise healthy humans (or any other higher primate). There are some significant negative side effects. https://peterattiamd.com/ama45/ https://peterattiamd.com/ama45/
- darkerside 3y ago
  I meant the magical part as tongue in cheek. I guess that doesn't come across well in text. My conjecture is that the anecdotal or limited evidence could be conflated with an improvement of latent infections, which would be an inconsistent effect.

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