4 ms·
I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a probl
by Sakos 3y ago
I think you're misinterpreting it. The full quote:
> Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have:
> When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the treatment effect is so great, and the true target population so common in the assembled denominator, that any corresponding signal dilutions are offset. The present study suggests that, even with definitions as amorphous and heterogenous as those currently in use for diagnosing long COVID, there was to be found within this study population an ample cohort of individuals with syndromes similar enough that disease incidence could be modified, and metformin appeared to achieve that. Furthermore, the finding that long COVID is modifiable, although here showing prevention, offers hope. . .
This is definitely the first time I've seen anything showing a reliable effect on long Covid. Pretty much everything else I've seen has been a collective shoulder shrug of "well, we saw this, and it's maybe something about Covid, but we really don't know, and we have no idea how to treat this" and a bunch of people saying "it's just a possible side effect of an infection, we've been seeing this for decades". I have no idea how you can dismiss this as something we already know and that this isn't a positive and meaningful step forward.
- hilbertseries 3y agoYou’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01359-7 https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-triple-therapy.pdf https://medhelpclinics.com/uploads/files/anticoagulant-tripl...
- henearkr 3y agoAnd, recently discovered too, inflammation-induced neuron mergings.
- darkerside 3y agoParent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.
- ethanbond 3y agoThey’re quite clearly saying that the effectiveness of the treatment is actually “the first” solid evidence of the disease. Which is wrong, it’s not the first, but it is also pretty darn good evidence to add to the pile, so it’s not that wrong. It’s just the evidence that appears to have convinced GP, which is cool to see happen in real time!
- hilbertseries 3y agoTriple therapy is a treatment that proceeds it. Metformin isn’t a treatment, it’s a prophylactic.
- darkerside 3y agoYes, a prophylactic treatment. I think my point stands, semantics aside.
- hilbertseries 3y agoIt's not the first evidence of treatment and preventing isn't the same as treating, because it does nothing for people who have the disease.
- darkerside 3y agoCan you share prior evidence of effective treatment? It's the first I've heard of it, and obviously the same goes for parent poster. I understand the distinction you are making, and that's why I said semantics aside.
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