> You can explain one of the many reasons why gain of function research is necessary: anticipating next year’s version of the flu, designing drugs and vaccines

> You can explain one of the many reasons why gain of function research is necessary: anticipating next year’s version of the flu, designing drugs and vaccines such that resistance mutations reduce evolutionary fitness. None of these require gain of function research. > You can explain some of the safeguards in place: BSL 3/4 facilities, regulatory / institutional oversight, security services, etc. All of these have a long history of failures [1,2]. And those are just the acknowledged, some have actually been covered up [3]. [1] https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity_incidents https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity... [2] https://www.amazon.ca/Pandoras-Gamble-Leaks-Pandemics-World/dp/1546002936/ https://www.amazon.ca/Pandoras-Gamble-Leaks-Pandemics-World/... [3] https://health.wusf.usf.edu/health-news-florida/2023-04-25/did-a-military-lab-spill-anthrax-into-public-waterways-book-reveals-details-of-a-us-leak https://health.wusf.usf.edu/health-news-florida/2023-04-25/d...