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what...? It's not some simplification to make toy problems for freshman. It's literally be always correct till they just discovered this thing From what I unde

what...? It's not some simplification to make toy problems for freshman. It's literally be always correct till they just discovered this thing From what I understand it's the first case of "Temperature-dependent RNA editing" ever observed

joshuahedlund 3y ago
> till they just discovered this thing There’s introns, alternate splicings… lots of very common exceptions/complications to the central dogma that I never knew about until I started learning more than high school biology. This is discovery of a new form of post-transcription modification, but it’s not the first.
pfisherman 3y ago
Lol! What makes a lung epithelial cell different from an alveolar cell? They both carry a copy of the entire genome. How do cells transduce mechanical, chemical, and environmental signals / stresses to alter gene expression?
- contrarian1234 3y ago
  gene expression/inhibition doesn't require gene editing
  - pfisherman 3y ago
    I am not sure what you are getting at. Epigenetic modification of the genome (methylation, acylation, TAD formation, etc) is not gene editing, but it is most certainly modification of the genome.
  - echelon 3y ago
    Somatic recombination. Transposons. Barr bodies. It gets even wilder when you start looking at other animals and kingdoms of life.
- visarga 3y ago
  I am not a biologist, but from what I understand the gene regulatory network is like a neural network, so it could encode arbitrary behaviour as selected by evolution. Maybe someone who knows what they are talking about could chime in.
  - VeninVidiaVicii 3y ago
    It was rhetorical. The answer is immaterial, just that the question presented a clear deviation from the dogma.
  - melagonster 3y ago
    this is more like a question of development biology. gene regulation play important role during development of cell. so the common question is what decide the fate of cells? and this is difficult. the normal explanation in textbook: when embryo develop, cell grow up to specific type by many different way(surely gene regulation), and in the whole life of individual cell just mitosis.
kjkjadksj 3y ago
Rna is still encoding for protein though and dna is still encoding for rna which then gets processed. Plenty of rna is spliced after transcription in many species.
vikramkr 3y ago
My take is that it's not a simplification - it's just incomplete. Presenting it as the only way things work is just incorrect and an unnecessary lie to teach students. But it is one way things work and a pretty important one at that. We've known about a myriad other interactions between dna, rna, and protein for a while though
CatWChainsaw 3y ago
...Are you unaware that HIV works, and has always worked, by using reverse transcriptase, which inputs RNA and outputs DNA? It may be a simplification in that it's the default, but it is not "literally always correct".

joshuahedlund 3y ago

> till they just discovered this thing There’s introns, alternate splicings… lots of very common exceptions/complications to the central dogma that I never knew about until I started learning more than high school biology. This is discovery of a new form of post-transcription modification, but it’s not the first.

pfisherman 3y ago

Lol! What makes a lung epithelial cell different from an alveolar cell? They both carry a copy of the entire genome. How do cells transduce mechanical, chemical, and environmental signals / stresses to alter gene expression?

contrarian1234 3y ago
gene expression/inhibition doesn't require gene editing
- pfisherman 3y ago
  I am not sure what you are getting at. Epigenetic modification of the genome (methylation, acylation, TAD formation, etc) is not gene editing, but it is most certainly modification of the genome.
- echelon 3y ago
  Somatic recombination. Transposons. Barr bodies. It gets even wilder when you start looking at other animals and kingdoms of life.
visarga 3y ago
I am not a biologist, but from what I understand the gene regulatory network is like a neural network, so it could encode arbitrary behaviour as selected by evolution. Maybe someone who knows what they are talking about could chime in.
- VeninVidiaVicii 3y ago
  It was rhetorical. The answer is immaterial, just that the question presented a clear deviation from the dogma.
- melagonster 3y ago
  this is more like a question of development biology. gene regulation play important role during development of cell. so the common question is what decide the fate of cells? and this is difficult. the normal explanation in textbook: when embryo develop, cell grow up to specific type by many different way(surely gene regulation), and in the whole life of individual cell just mitosis.

kjkjadksj 3y ago

Rna is still encoding for protein though and dna is still encoding for rna which then gets processed. Plenty of rna is spliced after transcription in many species.

vikramkr 3y ago

My take is that it's not a simplification - it's just incomplete. Presenting it as the only way things work is just incorrect and an unnecessary lie to teach students. But it is one way things work and a pretty important one at that. We've known about a myriad other interactions between dna, rna, and protein for a while though

CatWChainsaw 3y ago

...Are you unaware that HIV works, and has always worked, by using reverse transcriptase, which inputs RNA and outputs DNA? It may be a simplification in that it's the default, but it is not "literally always correct".