3 ms·
All the herpes family causes tons of health problems, HSV 1 & 2, EBV, Citomegalovirus .... (some of that problems recently discovered but also the main suspect
by Buxato 3y ago
All the herpes family causes tons of health problems, HSV 1 & 2, EBV, Citomegalovirus .... (some of that problems recently discovered but also the main suspect in many other diseases)
- haldujai 3y agoThe question becomes why do only certain people get the illness? 50-90% of the US population are EBV or CMV positive yet it’s a much smaller percentage that develop autoimmune illnesses. I’m the farthest thing from a rheumatologist but it seems like the favored explanation is a combination of infection and abnormal immune response.
- TeMPOraL 3y agoAt which point could this just be pure random chance? I.e. what if EBV or CMV or similar viruses poking at the immune system are like comic rays hitting non-ECC RAM? Most people won't notice most of the time, and some people will experience mysterious crashes or data corruption that don't seem to have any apparent cause.
- haldujai 3y agoGood question, I’m much more familiar with the oncology literature and there is definitely causative evidence linking EBV and to a lesser extent CMV with lymphoma/lymphoproliferative disorders (particularly in the post-transplant setting). I believe the evidence for autoimmune disorders is much weaker (with the caveat that this is well outside my scope of practice), I’ve heard it being implicated in MS from my neurology colleagues but my understanding is it’s a weak correlation at the moment. I can’t offer more than uneducated conjecture on other autoimmune diseases. UpToDate says the following: “One difficulty in proving a link between EBV and MS is that serological evidence of EBV can be found in 83 to 90 percent of adults in the Western hemisphere [99,101,102]. On the other hand, EBV seropositivity among adult MS patients is near 100 percent, significantly higher than healthy controls [91,102-106]. Additionally, children with MS are significantly more likely than healthy peers to have serological evidence for prior EBV infection, at an age when EBV seropositivity is much less common than in adults [107]. However, there is conflicting evidence concerning the presence of EBV in brain tissue of patients with MS [108-111].”
- zanfr 3y agoSARS 1 & 2 same deal
- onlyrealcuzzo 3y agoFor similar reasons why ~30% of the population has HSV-1 and never has any outbreaks and don't even know they have it.
- deleted 3y ago[deleted]
- djmips 3y agoI have a thought that only applies to the brain - perhaps mechanical injuries which can allow viruses to cross the blood brain barrier which only happen in a small subset of the population are the ones that are more likely to develop autoimmune disease in the brain. So a car accident which leads to a tear which allows virus into the brain which leads to autoimmune disease that affects the hippocampus which manifest as physical symptoms.
- RobotToaster 3y agoI guess the question is, how do we get rid of them?
- CommanderData 3y agoWe can't. It's likely impossible to completely remove these latent visues from our bodies. I've been reading into how they establish latentcy and in what cell types. They can infect almost any cell and establish latentcy, they prefer some cells that do not undergo apoptosis, near the brain. There isn't enough funding in the area either.