“Cure” with GBM is a very lofty goal but the first phase II oncolytic virus trial was actually quite promising! 2 year survival doesn’t sound like a lot but co

“Cure” with GBM is a very lofty goal but the first phase II oncolytic virus trial was actually quite promising! 2 year survival doesn’t sound like a lot but considering the study included non-mutated GBM (the worst kind) this prognosis is ~3-4x longer than with current treatment options. GBM (IDH-wt) is, unfortunately, extremely aggressive and not uncommon. Arguably the worst type of cancer for an adult. As a small silver lining the dismal prognosis means experimental therapies are possible on compassionate grounds and trials are expedited. We’ve also gotten much better as histologically and radiologically evaluating the disease. I’m cautiously optimistic it won’t be the immediate death sentence it currently is within my career, but it does appear we are still a few breakthroughs away from that being possible. https://www.nature.com/articles/s41591-022-01897-x https://www.nature.com/articles/s41591-022-01897-x