3 ms·
So about ten years to significant human trials. Be dubious of any headline with "cure" in it. I remember when reovirus and modified adenovirus were supposed to
by swader999 3y ago
So about ten years to significant human trials. Be dubious of any headline with "cure" in it.
I remember when reovirus and modified adenovirus were supposed to be the ticket for glio. Such a terrible thing, hope this is faster to the mark than my jaded forecast.
- haldujai 3y ago“Cure” with GBM is a very lofty goal but the first phase II oncolytic virus trial was actually quite promising! 2 year survival doesn’t sound like a lot but considering the study included non-mutated GBM (the worst kind) this prognosis is ~3-4x longer than with current treatment options. GBM (IDH-wt) is, unfortunately, extremely aggressive and not uncommon. Arguably the worst type of cancer for an adult. As a small silver lining the dismal prognosis means experimental therapies are possible on compassionate grounds and trials are expedited. We’ve also gotten much better as histologically and radiologically evaluating the disease. I’m cautiously optimistic it won’t be the immediate death sentence it currently is within my career, but it does appear we are still a few breakthroughs away from that being possible. https://www.nature.com/articles/s41591-022-01897-x https://www.nature.com/articles/s41591-022-01897-x
- swader999 3y agoI heard one surgeon describe operating on glio similar to trying to remove cottage cheese that's been randomly mixed in to a tub of margarine. You have to get it out without disturbing or taking out too much of the margarine.