4 ms·

I know we're only supposed to comment on the articles but I've tried 3 different computers, 4 browsers, and two IP addresses and I still just get a blank white

I know we're only supposed to comment on the articles but I've tried 3 different computers, 4 browsers, and two IP addresses and I still just get a blank white page. Even with all javascript enabled, etc. The Lancet jumped the shark in late 2019 and has only been getting worse. Their website is literally not performing it's function to distribute text. At least I could still get the full article at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079373/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079373/ "Booster effectiveness relative to primary series was 26·2% (95% CI 23·6–28·6) against infection and 75·1% (40·2–89·6) against severe, critical, or fatal COVID-19, during 1-year follow-up after the booster." That's not as bad as I thought it would be. The intramuscular's humoral) immunity against severe disease in the body serum and organs holds up pretty well. The protection against infection, which relies on upper respiratory mucosal immunity that injections into the arm don't give, are predictably low. I really wish the USA was still funding vaccine research so that some of these intranasal booster trials could be sped up. I haven't heard much about India's approved iNCOVACC intranasal role-out (starting this past ~feb), but the papers on it's effectiveness against infection should be out soon.

mikeyouse 3y ago
Must be your settings - Do you have a misconfigured PiHole or something? it works perfectly fine for me.. direct link to the PDF maybe? https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823%2900058-0 https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823...
George83728 3y ago
Odd. The lancet link loads fine for me with all javascript (including first party) disabled. In my experience, disabling all javascript fixes websites more often than it breaks them (most javascript only exists to create nuisances), so I leave it all disabled by default.
- Workaccount2 3y ago
  Same experience, firefox with noscript blocking everything, page loads fine.
abracadaniel 3y ago
https://web.archive.org/web/20230525154103/https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00058-0/fulltext https://web.archive.org/web/20230525154103/https://www.thela...
purpleblue 3y ago
What does 26.2% effective mean in this context?
- Scoundreller 3y ago
  Against infection, which: > Incidence of infection was defined as the first PCR-positive or rapid antigen-positive test after the start of follow-up, regardless of symptoms. > all rapid antigen tests conducted at health-care facilities (appendix p 9). SARS-CoV-2 testing is widely available and performed extensively in Qatar, mostly for non-clinical reasons.1, 12 Most infections are diagnosed not because of symptoms, but because of routine testing (appendix p 3). So they’re even capturing non-symptomatic infections, which you may not really care about. If a booster turned a symptomatic infection into a non-symptomatic infection, it would still be captured here and make it look like a booster failure. Not sure how well Qatar captured symptomatic infections.
- fauxpause_ 3y ago
  Relative effectiveness. It means you were 26% less likely to get COVID vs those with the vaccine but no booster

mikeyouse 3y ago

Must be your settings - Do you have a misconfigured PiHole or something? it works perfectly fine for me.. direct link to the PDF maybe? https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823%2900058-0 https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823...

George83728 3y ago

Odd. The lancet link loads fine for me with all javascript (including first party) disabled. In my experience, disabling all javascript fixes websites more often than it breaks them (most javascript only exists to create nuisances), so I leave it all disabled by default.

Workaccount2 3y ago
Same experience, firefox with noscript blocking everything, page loads fine.

abracadaniel 3y ago

https://web.archive.org/web/20230525154103/https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00058-0/fulltext https://web.archive.org/web/20230525154103/https://www.thela...

purpleblue 3y ago

What does 26.2% effective mean in this context?

Scoundreller 3y ago
Against infection, which: > Incidence of infection was defined as the first PCR-positive or rapid antigen-positive test after the start of follow-up, regardless of symptoms. > all rapid antigen tests conducted at health-care facilities (appendix p 9). SARS-CoV-2 testing is widely available and performed extensively in Qatar, mostly for non-clinical reasons.1, 12 Most infections are diagnosed not because of symptoms, but because of routine testing (appendix p 3). So they’re even capturing non-symptomatic infections, which you may not really care about. If a booster turned a symptomatic infection into a non-symptomatic infection, it would still be captured here and make it look like a booster failure. Not sure how well Qatar captured symptomatic infections.
fauxpause_ 3y ago
Relative effectiveness. It means you were 26% less likely to get COVID vs those with the vaccine but no booster