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For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orex

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field. 1. https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf

yieldcrv 3y ago
can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually work out!
- Red_Leaves_Flyy 3y ago
  Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.
  - yieldcrv 3y ago
    Then some people would feel there is a lopsided power dynamic in their choice to take them. In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations
- Earw0rm 3y ago
  Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
  - yieldcrv 3y ago
    > Find the right exercise/workout for you and it'll be its own reward. appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.
    - Earw0rm 3y ago
      That's not so easy, but also not as hard as you think. Won't take a lot of time on any one thing to see if it clicks for you. Pick a couple of activities, do each from absolute beginner level, twice a week for four weeks. Once if you're pushed for time. Keep the one that sucks less after a month. You don't need to hear the voice of God to download the Couch to 5K running app, grab a basic weights set and watch a few vids on simple exercises, or sign up for a local yoga or spin session. The high can be way better than you'd believe possible before you try. Or if you don't believe personal anecdote.. /something/ must be keeping all those people coming back to it at considerable expense, hassle and time.
    - nebulousthree 3y ago
      The pleasure of working out only becomes obvious after you've built the habit to do so. You'll know you've built the habit when it starts to feel bad when you don't work out on a day you're normally supposed to. It's pretty similar to a drug addiction.
      - bevesce- 3y ago
        I've been doing calisthenics 3 times a week since 2019. When I skip a day I feel enormous amount of guilt and I can't sleep when the night comes. Still, I don't like every moment of doing the exercises and I have a feeling of time being wasted by tending to my body instead of doing something with my family, cooking for them or being creative. What's more doing the workout eats a huge amount of my will power and leaves me unwilling to do any other chore for that day.
- deleted 3y ago
  [deleted]
- kika 3y ago
  Empath mode is oxytocin injection. Joking? Or not?
tick_tock_tick 3y ago
> yeah turns out it was never about will power. What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.
- beebmam 3y ago
  Free will has not been shown to exist. Everything is nature.
  - leroy-is-here 3y ago
    Reality does not need to be peer-reviewed to be true.
    - pasquinelli 3y ago
      how could you separate actually will power from the illusion of will power?
      - 0cVlTeIATBs 3y ago
        You know the conversation has strayed once you start debating epistemology.
        AndrewKemendo 3y ago
        This is the opposite of straying it’s actually a real conversation
        ChainOfFools 3y ago
        What's that old quote, you're not getting somewhere until you're going nowhere
      - rblatz 3y ago
        I always thought that it’s uncertain if free will exists, but you have to behave as if it does otherwise the world falls into chaos.
imtringued 3y ago
People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese (all it takes is a portion size that is slightly too big and demanding that you eat the full plate). No amount of willpower is going to end that unless you want to blame children for not running away from home.
- fatnoah 3y ago
  > People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese As a very young child, my family was probably on the upper end of poor. "Treats" were rare and food was not anything to be wasted at all. I'm almost 50 now, and it's virtually impossible for me to throw away food. I have to have an inner monologue conversation with myself about whether I really need to finish my portion and whether it's OK to discard it. Needless to say, despite being very physically active, my weight has challenged me my entire life. As a parent, I'm irrationally proud of my child for being able to stop eating when they're full, even if it's ice cream or a treat. That's actually helped me get over throwing food away (a little bit, at least)

yieldcrv 3y ago

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually work out!

Red_Leaves_Flyy 3y ago
Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.
- yieldcrv 3y ago
  Then some people would feel there is a lopsided power dynamic in their choice to take them. In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations
Earw0rm 3y ago
Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
- yieldcrv 3y ago
  > Find the right exercise/workout for you and it'll be its own reward. appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.
  - Earw0rm 3y ago
    That's not so easy, but also not as hard as you think. Won't take a lot of time on any one thing to see if it clicks for you. Pick a couple of activities, do each from absolute beginner level, twice a week for four weeks. Once if you're pushed for time. Keep the one that sucks less after a month. You don't need to hear the voice of God to download the Couch to 5K running app, grab a basic weights set and watch a few vids on simple exercises, or sign up for a local yoga or spin session. The high can be way better than you'd believe possible before you try. Or if you don't believe personal anecdote.. /something/ must be keeping all those people coming back to it at considerable expense, hassle and time.
  - nebulousthree 3y ago
    The pleasure of working out only becomes obvious after you've built the habit to do so. You'll know you've built the habit when it starts to feel bad when you don't work out on a day you're normally supposed to. It's pretty similar to a drug addiction.
    - bevesce- 3y ago
      I've been doing calisthenics 3 times a week since 2019. When I skip a day I feel enormous amount of guilt and I can't sleep when the night comes. Still, I don't like every moment of doing the exercises and I have a feeling of time being wasted by tending to my body instead of doing something with my family, cooking for them or being creative. What's more doing the workout eats a huge amount of my will power and leaves me unwilling to do any other chore for that day.
deleted 3y ago
[deleted]
kika 3y ago
Empath mode is oxytocin injection. Joking? Or not?

tick_tock_tick 3y ago

> yeah turns out it was never about will power. What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.

beebmam 3y ago
Free will has not been shown to exist. Everything is nature.
- leroy-is-here 3y ago
  Reality does not need to be peer-reviewed to be true.
  - pasquinelli 3y ago
    how could you separate actually will power from the illusion of will power?
    - 0cVlTeIATBs 3y ago
      You know the conversation has strayed once you start debating epistemology.
      - AndrewKemendo 3y ago
        This is the opposite of straying it’s actually a real conversation
        ChainOfFools 3y ago
        What's that old quote, you're not getting somewhere until you're going nowhere
    - rblatz 3y ago
      I always thought that it’s uncertain if free will exists, but you have to behave as if it does otherwise the world falls into chaos.

imtringued 3y ago

People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese (all it takes is a portion size that is slightly too big and demanding that you eat the full plate). No amount of willpower is going to end that unless you want to blame children for not running away from home.

fatnoah 3y ago
> People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese As a very young child, my family was probably on the upper end of poor. "Treats" were rare and food was not anything to be wasted at all. I'm almost 50 now, and it's virtually impossible for me to throw away food. I have to have an inner monologue conversation with myself about whether I really need to finish my portion and whether it's OK to discard it. Needless to say, despite being very physically active, my weight has challenged me my entire life. As a parent, I'm irrationally proud of my child for being able to stop eating when they're full, even if it's ice cream or a treat. That's actually helped me get over throwing food away (a little bit, at least)