6 ms·
RNA repair mechanism discovered in humans
- p1esk 3y agoIs this relevant for anti-aging research? How significant is this paper in that context?
- stubybubs 3y agoLarry Ellison, is that you?
- spurgu 3y agoI suggest you look into David Sinclair, he's done some interesting research with epigenetics.
- shpongled 3y agoDavid Sinclair is considered to be a quack (bordering on a fraud) by many within the scientific community.
- meowkit 3y agoSo I guess we're at the point which Harvard Medical School isn't good signal? https://sinclair.hms.harvard.edu/people/david-sinclair https://sinclair.hms.harvard.edu/people/david-sinclair Who considers him a quack? Why should I believe them?
- shpongled 3y agoThe former dean of Harvard Medical School: https://twitter.com/jflier/status/1495833104510038026 https://twitter.com/jflier/status/1495833104510038026 A slew of retracted papers from his mentor's lab, and image duplications/fabricated western blots from David's lab: https://forbetterscience.com/2020/05/14/never-ageing-anti-aging-to-cure-covid-19/ https://forbetterscience.com/2020/05/14/never-ageing-anti-ag... https://forbetterscience.com/2023/04/17/the-original-sins-of-leonard-guarente/ https://forbetterscience.com/2023/04/17/the-original-sins-of... Several blog posts on the resveratrol controversy by Derek Lowe (required reading in pharma/biotech): https://www.science.org/content/blog-post/resveratrol-srt501-buy-now---why-wait https://www.science.org/content/blog-post/resveratrol-srt501... https://www.science.org/content/blog-post/does-resveratrol-really-work-and-does-srt1720 https://www.science.org/content/blog-post/does-resveratrol-r... https://www.science.org/content/blog-post/resveratrol-humans-results-controlled-trial https://www.science.org/content/blog-post/resveratrol-humans... https://www.science.org/content/blog-post/latest-sirtuin-controversy https://www.science.org/content/blog-post/latest-sirtuin-con... Also anecdotal, but I personally know several PIs who worked on sirtuins during their PhDs and they all say that David is full of shit.
- vhcr 3y agoYou're gonna need to backup your claim, because a quick google search didn't lead me to anything.
- altvali 3y agoNot the person you're replying to, but this is what I found after a quick google search: Dr. Jeffrey Flier: https://twitter.com/jflier/status/1495909501211447305?s=21 https://twitter.com/jflier/status/1495909501211447305?s=21 Dr. Charles Brenner: https://twitter.com/CharlesMBrenner/status/1496604055799361537?lang=en https://twitter.com/CharlesMBrenner/status/14966040557993615... Dr. Brad Stanfield: https://www.youtube.com/watch?v=JAFnD27ffqE https://www.youtube.com/watch?v=JAFnD27ffqE
- shpongled 3y agoSee the tweets from the other replier, as well as my reply above.
- irrational 3y agoMy grandmother just celebrated her 100th birthday. She still lives on her own, drives, does her own cooking, walks unassisted, etc. When I mentioned I was going out of town for her 100th birthday party, people kept saying she must have good genes. Maybe so. Maybe she has some sort of really good RNA repair mechanism.
- ggm 3y agoIf she has a good RNA repair mechanism isn't it heritable or do you posit she bought it or made it from wool and toothpicks?
- irrational 3y agoMaybe inherited, maybe a mutation unique to herself.
- svnt 3y agoYour response seems to miss the difference between the terms inherited and heritable (because it could be heritable without being inherited), but your point is valid: whatever she has may be cognitive, biological, or otherwise, and may or may not have heritable aspects.
- ggm 3y agoA cognitive repair mechanism for RNA. That's novel. Intracellular functions are defined by gene expression, I don't think meditation or yoga is going to do it although I suppose suppression of stress hormones might influence cell function. Put it this way: it's more likely cognitive than knitting and toothpicks.
- svnt 3y agoThe science is starting to stack up in favor: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134740/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134740/
- evrimoztamur 3y agoI believe that humans have not yet created any system more complicated than our own bodies. In turn, I think the same claim holds for our own brains too. We are in for a series of revelations that will deeply alter the way we understand the microscopic intricacies that hold us upright and posting on internet forums. Exciting things happening in the field!
- motoboi 3y agoThe brain is the most complex object in the known universe.
- quijoteuniv 3y agoKnown by who?
- lksjdflksdj9 3y ago^^ this
- khazhoux 3y agoIn common parlance, “known universe” refers to the extent of the universe that is observable by human beings on the planet earth. Hope that helps!
- detrites 3y agoI took it as an intelligent way to poise an interesting counterpoint to assumption. You took it as...?
- khazhoux 3y agoCounterpoint to what assumption? To the idea that the brain is complex? Or was it a cryptic way to imply that there might be other sentience with more-advanced “brains”?
- DoreenMichele 3y agoEither the article leaves out something or the title is misleading. It's an antioxidant defense system that protects against cellular distress. The article doesn't seem to describe repair work. Did I miss some detail?
- jjtheblunt 3y agoIsn't the repair work that of the RNA ligases, whose particular versions for humans are first mentioned here? > "In order to fulfill their diverse functions in the cell, RNAs often need to be chemically modified after their creation or repaired after damage," explains Andreas Marx, professor of organic and cellular chemistry at the University of Konstanz. > One chemical reaction that plays a role here is the three-step linking (ligation) of two RNA strands at their respective opposite ends. This reaction is triggered by specialized enzymes called RNA ligases and is present in all forms of life, from viruses to fungi and plants. In vertebrates, including humans, such RNA ligases had yet to be identified. > An interdisciplinary research team from Konstanz has now discovered the first human RNA ligase of this type, the protein C12orf29."
- DoreenMichele 3y agoAh. Ok. I see why you would infer that. But it's an inference -- an assumption that human ligases will do what ligases do in other species and that's not what the actual research shows, at least not that the article indicates. We've just discovered these. They are investigating what they do. Their investigation shows they protect against oxidative stress, which is significant.
- dekhn 3y agoI generally agree with your assessment. I skimmed the paper and there really isn't any direct evidence that it's a "repair mechanism" beyond the apparent effects of knocking out the gene: cells die faster, and degradation of ribosomal RNA is faster. The presumed mechanism here would be oxidative stress->damage to rRNA->reduced protein production/increased error rate in proteins->cell is not happy, with the RNA ligase playing the role of repairing localized damage caused by stress thus allowing the cell to continue at its normal rate. There also isn't any strong evidence that this system resembles the ones seen in viruses and bacteria. There are many RNA ligases that have many different roles and the variations aren't shared between all kingdoms of life.
- samstave 3y ago[flagged]
- tbirdny 3y agoI'm looking forward to ways we can increase levels of C12orf29 or supplement it somehow in hopes of boosting RNA repair.
- throwaway12245 3y agoHuman tissues may be fine tuned to need a specific range of C12orf29 molecule quantities: too many or too few might be big problems. See https://www.proteinatlas.org/search/C12orf29 https://www.proteinatlas.org/search/C12orf29 for the gene expression for various tissues.
- firstlink 3y agoHow does this fit into the https://en.m.wikipedia.org/wiki/Central_dogma_of_molecular_biology https://en.m.wikipedia.org/wiki/Central_dogma_of_molecular_b... according to which RNA is short-lived?
- getoffmycase 3y agoRNA is generally short lived. But specific kinds of RNA can have longer lifetimes. It’s accurate to say that RNA lifetime is extremely tightly regulated, and most of the time that means that it is short lived. Its lifetime is also extremely short compared to DNA and a high percentage of proteins.
- dekhn 3y agoThe central dogma doesn't really cover the form of RNA that is speculated to be repaired here: ribosomal RNA. The central dogma concerns mainly the transcription of DNA to mRNA, the reverse transcription of RNA back to DNA, and the translation of mRNA to protein. But over time RNA has turned up in a wide range of other activities. In this case, ribosomal RNA is the functional heart of the ribosome- the machine that translates mRNA to protein. Ribosomal RNA represents a very significant investment of resources for the cell and so if it gets damaged, the cell won't be able to make proteins as quickly, or the proteins that get made might have errors, both of which have dire effects on the cell.
- dist-epoch 3y agoEven that page acknowledges that this dogma is a simplification of reality: > Transfers of information not explicitly covered in the theory