4 ms·
> Some people at risk for the disease have antibodies against this bacteria, and Subdoligranulum activation of T cells was more prevalent in people with RA than
by anonymouskimmer 4y ago
> Some people at risk for the disease have antibodies against this bacteria, and Subdoligranulum activation of T cells was more prevalent in people with RA than in healthy controls.
Very important to qualify (through studies) whether this is the cause of rheumatoid arthritis, or just one of a number of precipitating things. The answer will tell us whether treating/preventing Subdoligranulum is a silver bullet, or whether, like cancer, we have a lot more work to do.
> “It's hard to know how big of a player this specific isolate is,” he said. “It could be the dominant player, and that's why they came across it first. But it could be that if they went back and did larger screens, that they would come up with more — that [Subdoligranulum] would be just one of many.”
> In keeping with this, the researchers only found this Subdoligranulum strain in 16.7 percent of people at risk or with early-stage RA, indicating that this strain is likely not the sole driver of disease.
Regardless, given the results mentioned here, I would bet that "infection" with this strain would exacerbate RA through increased production of antibodies. So it seems a good target to reduce severe RA.
- davidjones332 4y ago[dead]
- kstrauser 4y agoAnd it's not unprecedented. It was in my lifetime that we found out that stomach ulcers could be caused by H. pylori infections. For many people, what'd previously been a chronic condition could be cured with a round of antibiotics.
- darkerside 4y agoLyme disease also causes symptoms that overlap with RA, due to the Borrelia burgdorferi bacteria. It is latent in some people and causes serious symptoms in others. I truly wonder sometimes whether antibiotics are actually underused in medicine (while simultaneously being overused in the food supply chain).
- hospitalJail 4y ago>I truly wonder sometimes whether antibiotics are actually underused in medicine (while simultaneously being overused in the food supply chain). In the US, this is basically a given. You don't have to look past the lobbying numbers to understand why. I'm curious outside the US, how often antibiotics are given out. From my buddies telling me stories about Mexico + the fear mongering with US Physicians, you'd expect a superbug to have broken out by now.
- moneywoes 4y agoWhat about the whole super bug antibiotic resistant thing
- dopkew 4y agoThere are some who propound a more nuanced approach: https://news.ycombinator.com/item?id=35704698 https://news.ycombinator.com/item?id=35704698
- nradov 4y agoMultiple superbugs have broken out and are killing thousands every year. The irresponsible overuse of antibiotics in places like Mexico is certainly part of the problem. https://www.cdc.gov/drugresistance/about.html https://www.cdc.gov/drugresistance/about.html
- hospitalJail 4y agohttps://en.wikipedia.org/wiki/Clostridioides_difficile_infection#Cause https://en.wikipedia.org/wiki/Clostridioides_difficile_infec... There is no mention on your page, or the wiki, that antibiotics are the cause the resistant bacteria. I can logically see why we would believe this, but you'd expect given the use of antibiotics on the farm and in non US pharmacies; we'd have such a superbug scientifically proven by now.
- anonymouskimmer 4y ago
- barbariangrunge 4y agoI speculated last year that various known diseases could turn out to have some sort of microbe, or microbe-like cause that we're unaware of; things we haven't seen or noticed yet. And that we might occasionally find out, with new tools, that a difficult condition has an understandable, discrete, physical cause. Similar to how people discovered that the flu and strep-throat and meningitis etc were caused by the tiny living or life-like critters (are viruses alive?). I was insulted and mocked by everyone I said it to But if nobody looks, we'll never find out. It looks like somebody looked in the case of ulcers and arthritis
- f6v 4y ago> I was insulted and mocked by everyone I said it to I mean, it’s not a fringe theory. MS could be one example.
- graeme 4y agoGerm theory is not widely believed. Not really. We wash our hands because we've been trained since a young age to do so, and generally accept that touching stuff is unsanitary. But that's about it. Witness the reaction to aerosol spread of disease despite literal videos that can capture and show aerosols being spread around a room. People simply don't believe it. They likewise don't believe in any kind of long run response to an infection. We associate the symptoms of acute immune response to be the virus itself, and the entirety of the virus.
- throwaway22032 4y agoYou're conflating two issues here. I believe that car accidents cost lives, that power tools can take off my fingers, that illnesses like coronavirus can kill me or give me chronic lung conditions. I also believe that it's worth driving, woodworking, and interacting with people in public despite those risks. Most people, excluding the rare nutjobs, are like that. If you force them on an issue and don't accept variants of "I don't care" as an answer, they might come up with a bizarre explanation, sure. It's hard for a lot of people to simply be honest and say - yes, sure, but I think it's worth it, instead of trying to deflect.
- jachee 4y ago> Very important to qualify (through studies) whether this is the cause of rheumatoid arthritis, or just one of a number of precipitating things. The answer will tell us whether treating/preventing Subdoligranulum is a silver bullet, or whether, like cancer, we have a lot more work to do. A subsequent study[0]—albeit with a very small sample size—“proves the causative relation between … periodontal pathogens and RA.” (Or at least flares thereof.) https://www.drugdiscoverynews.com/mouth-bacteria-trigger-rheumatoid-arthritis-by-breaking-into-the-blood-15638 https://www.drugdiscoverynews.com/mouth-bacteria-trigger-rhe...