R01s are too small to be worth applying for, typically. Or rather, most PIs have an R01 that pays for themselves and maybe some travel and publication feeds. M

R01s are too small to be worth applying for, typically. Or rather, most PIs have an R01 that pays for themselves and maybe some travel and publication feeds. Most of these people end up making center grants or finding other mechanisms (like non-NIH funding, such as CZI). There's no way I personally would have been able to manage 5-6 active R01s a year; but then, when I did grant review, I noticed that other folks did a lot of copy/pasting and exagerating about their publications significance, which is not something I was willing to do.