3 ms·

> transfer of unlearned behavior with brain extracts I'm surprised that it works.

ly3xqhl8g9 4y ago
Moths remember what they learned as caterpillars [1]. Memory transfer via RNA injections has also been achieved in snails and flatworms [2] [3]. Memory transfer and memory markets will probably be a thing sometime by 2100, perhaps even synthetic memory markets, let stable diffusion reimagine your past. [1] "M. sexta larvae can learn to associate odor cues with an aversive stimulus, and this memory persists undiminished across two larval molts, as well as into adulthood. The behavior represents true associative learning, not chemical legacy, and, as far as we know, provides the first definitive demonstration that associative memory survives metamorphosis in Lepidoptera." https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001736 https://journals.plos.org/plosone/article?id=10.1371/journal... [2] "Glanzman said one of McConnell’s students, Al Jacobson, demonstrated the transfer of memories between flatworms via RNA injections, coincidentally while an assistant professor at UCLA. The work was published in Nature in 1966 but Jacobson never received tenure, perhaps because of doubts about his findings. The experiment was, however, replicated in rats shortly afterward." https://www.scientificamerican.com/article/memory-transferred-between-snails-challenging-standard-theory-of-how-the-brain-remembers https://www.scientificamerican.com/article/memory-transferre... Jacobson's 1966 article, https://pubmed.ncbi.nlm.nih.gov/5921188 https://pubmed.ncbi.nlm.nih.gov/5921188 [3] Memory in the flesh, https://www.theverge.com/2015/3/18/8225321/memory-research-flatworm-cannibalism-james-mcconnell-michael-levin https://www.theverge.com/2015/3/18/8225321/memory-research-f...
- dekhn 4y ago
  Generally memory transfer by mRNA is not considered to be a well-established phenomenon.
  - ly3xqhl8g9 4y ago
    The snails paper [1] does not mention mRNA, or the RNA type at all. But sure, there are lots to learn and there are more questions than answers. [1] RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia, https://www.eneuro.org/content/5/3/ENEURO.0038-18.2018 https://www.eneuro.org/content/5/3/ENEURO.0038-18.2018
stareatgoats 4y ago
I'm surprised that you got downvoted. Of course it is surprising.
bhickey 4y ago
That's because it doesn't. Take a look at papers citing _The transfer of learned behavior from trained to untrained rats by mean of brain extracts._

Moths remember what they learned as caterpillars [1]. Memory transfer via RNA injections has also been achieved in snails and flatworms [2] [3]. Memory transfer and memory markets will probably be a thing sometime by 2100, perhaps even synthetic memory markets, let stable diffusion reimagine your past. [1] "M. sexta larvae can learn to associate odor cues with an aversive stimulus, and this memory persists undiminished across two larval molts, as well as into adulthood. The behavior represents true associative learning, not chemical legacy, and, as far as we know, provides the first definitive demonstration that associative memory survives metamorphosis in Lepidoptera." https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001736 https://journals.plos.org/plosone/article?id=10.1371/journal... [2] "Glanzman said one of McConnell’s students, Al Jacobson, demonstrated the transfer of memories between flatworms via RNA injections, coincidentally while an assistant professor at UCLA. The work was published in Nature in 1966 but Jacobson never received tenure, perhaps because of doubts about his findings. The experiment was, however, replicated in rats shortly afterward." https://www.scientificamerican.com/article/memory-transferred-between-snails-challenging-standard-theory-of-how-the-brain-remembers https://www.scientificamerican.com/article/memory-transferre... Jacobson's 1966 article, https://pubmed.ncbi.nlm.nih.gov/5921188 https://pubmed.ncbi.nlm.nih.gov/5921188 [3] Memory in the flesh, https://www.theverge.com/2015/3/18/8225321/memory-research-flatworm-cannibalism-james-mcconnell-michael-levin https://www.theverge.com/2015/3/18/8225321/memory-research-f...

dekhn 4y ago
Generally memory transfer by mRNA is not considered to be a well-established phenomenon.
- ly3xqhl8g9 4y ago
  The snails paper [1] does not mention mRNA, or the RNA type at all. But sure, there are lots to learn and there are more questions than answers. [1] RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia, https://www.eneuro.org/content/5/3/ENEURO.0038-18.2018 https://www.eneuro.org/content/5/3/ENEURO.0038-18.2018

stareatgoats 4y ago

I'm surprised that you got downvoted. Of course it is surprising.

bhickey 4y ago

That's because it doesn't. Take a look at papers citing _The transfer of learned behavior from trained to untrained rats by mean of brain extracts._