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You don't think research is searching for a safer alternative? It would be a major blockbuster drug. The reasons we have acetaminophen with all its risks is b
by refurb 4y ago
You don't think research is searching for a safer alternative? It would be a major blockbuster drug.
The reasons we have acetaminophen with all its risks is because there is nothing better.
- paulpauper 4y agoslow release oxycontin is safe and effective. except when people abuse it by crushing the pills.
- hilbert42 4y agoRight, opiates work wonderfully effective but how do you stop the abuse and subsequent addition and deaths?
- apple4ever 4y agoYou offer good addiction programs, and stop punishing people with jail for them.
- hilbert42 4y agoFor years pain research and pain alleviation was considered low priority by the medical profession. It strands to reason we need to understand and to continue researching pain before researching painkilling drugs—so we are coming from a low base. Even after the opioid epidemic and those disreputable Sackler bastards came to worldwide prominence there's been no national initiative like, say COVID research. The problem is that there is not enough research. That's clearly obvious—or it ought to be.
- refurb 4y agoPain research is front and center for many companies. Look at the Nav1.7 programs - many big pharmaceutical companies are working on them. I disagree 100% it's not a priority. The companies know they could make a ton of money off of an effective, but more safe pain medicine.
- NoZebra120vClip 4y ago> The reasons we have acetaminophen with all its risks is because there is nothing better. Of course there are better drugs. But they are not patentable, they are not profitable, and they are not synthesized by chemical factories like the Union Carbide in Bhopal. All of that makes them really unpopular!
- hilbert42 4y agoAcetaminophen is not patentable and it's dirt cheap to produce. So what unpatentable drugs are better?
- NoZebra120vClip 4y agoThat depends on what you call a "drug". Are we using the FDA definition?
- hilbert42 4y agoFDA or not, what are they?
- pfisherman 4y agoThis is a talking point I hear a lot that has little basis in fact. There are many active pharmaceutical ingredients that are natural products, modified natural products, or analogues of natural products. See Metformin and French Lilac. In fact, a big part of what medicinal chemists do is designing “better” molecules. And some well capitalized pharma companies even come out and say their strategy is “best in class, not first in class”.
- refurb 4y agoI mean, most OTC analgesic drugs aren't patentable either, yet companies happily sell them for a profit. Please list these "better" drugs, I'm eager to start a business around them.
- apple4ever 4y ago> The reasons we have acetaminophen with all its risks is because there is nothing better. There is, but we care more about stopping people getting high than we care about stopping people from being in pain. My wife had an outpatient surgery, and had muscle spasms from incisions. She was SCREAMING in pain. She was brought in by ambulance (who did not give her anything - sort of understandable because sometimes you need to have the patient identify the pain). Despite continuing to SCREAM in pain, the nurse refused to do anything or contact the doctor, because she was sure she was a druggy just faking it. It took all my energy not to start throwing punches. (A doctor finally got her pain meds.) Our society is unjust.