5 ms·
I don't think it's still manufactured, and maybe it's unrelated to this current situation, but around 8-15 years ago, one of the manufacturers of generic Addera
by blincoln 4y ago
I don't think it's still manufactured, and maybe it's unrelated to this current situation, but around 8-15 years ago, one of the manufacturers of generic Adderall XR did something that made it much less effective. It was obvious which ones were theirs, because they were the only company that put theirs in blue capsules.
Subjectively, it felt about half as effective as anyone else's. There were many, many forum discussions at the time from adults taking it as well as parents of kids who'd received it and noticed a big difference.
It was especially frustrating because of all the rigamarole one has to deal with to get the medication in the first place. To not have it work and also have to wait another month to get one that does is ridiculous.
I submitted a complaint to the FDA about it at the time. Never even got a form letter back. It's caused me to avoid generic drugs where possible ever since because if that can slip through, what else can?
I assumed at the time it was some difference in the capsule itself or the delayed-released mechanism, as opposed to the active ingredients being different.
- kkielhofner 4y agoYou see this with a lot of psychotropic medications (and likely others). It’s why when you fill a generic the label will specifically list the manufacturer. I’ve heard of at least a few instances with psych meds where people will either try to get a specific generic manufacturer or go back to name brand because of the significant impact due to variability you’re describing.
- drowsspa 4y agoI would also say that ADHD meds are much more susceptible to this, because the psychological effect is just so noticeable. Taking Vyvanse by itself compared with taking it with a little snack it makes quite a difference in the absorption for me; when I take it with Psyllium husk, then... EDIT: I guess I should expand on the effects of Psyllium. I mean the meds take longer to kick in
- liketochill 4y agoThen what?
- trillic 4y agoOP had no time to talk he was running for the bathroom. Stimulant + laxative = ICBM (immediately coming bowel movement)
- roer 4y agoI am in a similar situation as you and trying to figure out the best way to take my medication. I never really thought about my psyllium husks having an effect, so I'm very curious what you've noticed
- drowsspa 4y agoFrom what I read it doesn't seem like a good idea to take psyllium husk together with other medications. They seem to recommend one hour or two of interval between it and other meds. I don't know if it's just doctors being cautious, though. I usually take Vyvanse just by itself at around 7AM just before walking to the gym, so I guess I associate the effect kicking in to my walking back home. On the days I ate something together with it, or specially with Psyllium, I notice a diminished effect
- devdas 4y agoThat's normal. Fibre slows down the absorption of everything.
- freeflight 4y agoI wonder if these differences in effect might have to do with the emergence, and wider adoption, of abuse-deterrent formulations of drugs? Case in point; https://www.fiercepharma.com/pharma/vallons-abuse-resistant-adderall-fails-clinical-trial-causing-stock-crater https://www.fiercepharma.com/pharma/vallons-abuse-resistant-...