There is a detailed four article series about this which was recently shared here on Hacker News. The first article is here: https://www.jeffnobbs.com/posts/wh

There is a detailed four article series about this which was recently shared here on Hacker News. The first article is here: https://www.jeffnobbs.com/posts/what-causes-chronic-disease https://www.jeffnobbs.com/posts/what-causes-chronic-disease , but the second and third articles probably address this most directly. >> "the output is novel to humans on evolutionary scale" > > This is true for all oils and all other highly processed foods. That is not true. There is evidence that humans have sought out fats and oils for most of our history. Lard and other rendered fats are made from heating animal fats directly with modest heat being sufficient to liquify animal fats. Butter is made from churning milk. Olive oil and Coconut oil are made by squeezing fruits. All of that is quite different from modern vegetable oil processing which requires high temperatures which in turn convert a fraction of the oil into transfats. When oils refined in these ways are then used for cooking they become increasingly dangerous as they are heated.