4 ms·

There is a shit ton of evidence supporting vitamin d3 to fight covid...

by seper8 4y ago

treeman79 4y ago
[flagged]
dgacmu 4y ago
There's not, though. There's a ton of evidence that vitamin d _correlates_ with COVID outcomes, but this is vitamin d's superpower: it correlates with good outcomes for just about everything, but nearly every time there's a good high quality study, it turns out to not be causative. A bunch of those vitamin d and COVID studies were fraudulent. Vitamin d levels are an excellent marker of good health and they can help predict outcomes but supplementing vitamin d doesn't improve those outcomes. Regretfully. (Except rickets, of course.)
- seper8 4y ago
  Did you even do a single bit of research before boldly stating there is no research done on the supplementation? https://www.nature.com/articles/s41598-022-24053-4 https://www.nature.com/articles/s41598-022-24053-4 https://pubmed.ncbi.nlm.nih.gov/35166850/ https://pubmed.ncbi.nlm.nih.gov/35166850/ https://pmj.bmj.com/content/98/1156/87 https://pmj.bmj.com/content/98/1156/87 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268396 https://journals.plos.org/plosone/article?id=10.1371/journal...
  - dgacmu 4y ago
    Yes. There's a ton. Most of it is horribly tainted by correlation effects. Let's consider one of the studies you cited above, which is an observational study from the VA hospitals: "In the population of US veterans, we show that Vitamin D2 and D3 fills were associated with reductions in COVID-19 infection of 28% and 20%, respectively" This sounds really awesome, right? Except -- you could also interpret this as "People who are following their doctor's recommendations, going to the pharmacy to fill their prescriptions, and taking them, do better". No kidding - they're probably also taking their other medications and being more generally medically careful! This is completely consistent with the 99% of vitamin d-related results that show that it correlates with all sorts of positive outcomes. The high quality interventional studies -- which are actually potentially able to demonstrate causality -- are generally negative. And the larger and better they are, the more likely they are to be negative. One of the largest was the CORONAVIT trial; it was, unfortunately, open-label, but it was large and randomized. (Note that you'd expect the open-label aspect to result in a stronger placebo effect, which .. well, given that they found no benefits, did not occur). https://www.bmj.com/content/378/bmj-2022-071230 https://www.bmj.com/content/378/bmj-2022-071230 The vitamin d & covid horse is pretty dead at this point, which is basically the same as the "vitamin d & x" horse for most values of X other than diseases known to be directly caused by vitamin D deficiency. Which are serious and worthy of treatment. Just don't expect vitamin D to be a miracle cure on the basis of its correlation with everything positive.
- nradov 4y ago
  There are multiple clinical studies showing that vitamin D supplements can be effective in fighting COVID-19. Some other studies have shown no effect, but overall there seems to be some benefit. https://vitamin-d-covid.shotwell.ca/ https://vitamin-d-covid.shotwell.ca/
  - dgacmu 4y ago
    See my reply to the sibling comment.

There is a shit ton of evidence supporting vitamin d3 to fight covid...

by seper8 4y ago

There is a shit ton of evidence supporting vitamin d3 to fight covid...

treeman79 4y ago

[flagged]

dgacmu 4y ago

There's not, though. There's a ton of evidence that vitamin d _correlates_ with COVID outcomes, but this is vitamin d's superpower: it correlates with good outcomes for just about everything, but nearly every time there's a good high quality study, it turns out to not be causative. A bunch of those vitamin d and COVID studies were fraudulent. Vitamin d levels are an excellent marker of good health and they can help predict outcomes but supplementing vitamin d doesn't improve those outcomes. Regretfully. (Except rickets, of course.)

seper8 4y ago
Did you even do a single bit of research before boldly stating there is no research done on the supplementation? https://www.nature.com/articles/s41598-022-24053-4 https://www.nature.com/articles/s41598-022-24053-4 https://pubmed.ncbi.nlm.nih.gov/35166850/ https://pubmed.ncbi.nlm.nih.gov/35166850/ https://pmj.bmj.com/content/98/1156/87 https://pmj.bmj.com/content/98/1156/87 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268396 https://journals.plos.org/plosone/article?id=10.1371/journal...
- dgacmu 4y ago
  Yes. There's a ton. Most of it is horribly tainted by correlation effects. Let's consider one of the studies you cited above, which is an observational study from the VA hospitals: "In the population of US veterans, we show that Vitamin D2 and D3 fills were associated with reductions in COVID-19 infection of 28% and 20%, respectively" This sounds really awesome, right? Except -- you could also interpret this as "People who are following their doctor's recommendations, going to the pharmacy to fill their prescriptions, and taking them, do better". No kidding - they're probably also taking their other medications and being more generally medically careful! This is completely consistent with the 99% of vitamin d-related results that show that it correlates with all sorts of positive outcomes. The high quality interventional studies -- which are actually potentially able to demonstrate causality -- are generally negative. And the larger and better they are, the more likely they are to be negative. One of the largest was the CORONAVIT trial; it was, unfortunately, open-label, but it was large and randomized. (Note that you'd expect the open-label aspect to result in a stronger placebo effect, which .. well, given that they found no benefits, did not occur). https://www.bmj.com/content/378/bmj-2022-071230 https://www.bmj.com/content/378/bmj-2022-071230 The vitamin d & covid horse is pretty dead at this point, which is basically the same as the "vitamin d & x" horse for most values of X other than diseases known to be directly caused by vitamin D deficiency. Which are serious and worthy of treatment. Just don't expect vitamin D to be a miracle cure on the basis of its correlation with everything positive.
nradov 4y ago
There are multiple clinical studies showing that vitamin D supplements can be effective in fighting COVID-19. Some other studies have shown no effect, but overall there seems to be some benefit. https://vitamin-d-covid.shotwell.ca/ https://vitamin-d-covid.shotwell.ca/
- dgacmu 4y ago
  See my reply to the sibling comment.