5 ms·

Worse than not having fun; you have to take all these pills a day. https://blueprint.bryanjohnson.co/#step-2-supplements https://blueprint.bryanjohnson.co/#step

Worse than not having fun; you have to take all these pills a day. https://blueprint.bryanjohnson.co/#step-2-supplements https://blueprint.bryanjohnson.co/#step-2-supplements I think there's an in-between. Getting sleep. Fasting. Exercise. Avoiding sugar.

toomuchtodo 4y ago
These help, but genetics also play part. You can’t lifestyle your way out of bad genetics.
- nradov 4y ago
  To a limited extent you can medicate yourself out of some bad genetics. Statins and anti-hypertensives have really changed the game.
malfist 4y ago
Jesus why is he on so many diabetic meds? He's on metformin, taking 1500mg in the morning of an extended release, and 500mg extended release in the evening. Normal dosage for this is 500mg/day. Extended release means they stay in his system for 24 hours, no reason to take it in two doses, much less take 4x the normal amount. He's also on Acarbose, another diabetic med. The recommended dosing for this is 50mg 3 times per day and hes' taking two 200mg doses. This makes no sense, your body eliminates it quickly, halflife of 2 hours. It's also 6x the standard dose. He's also on Rapamycin, a cancer med or organ transplant med that is immunosupressive. Standard dose is 2mg/day. He's taking 13mg twice a week. He's also taking Testesterone 6 of 7 days of the week, and half your standard does. Total nonsense. This guy is going to wreck his kidney and liver with these meds, put himself at high risk of infection and disrupt his endocrine system. And that's just with his prescriptions, not even examining his supplements. All this to brag that he's as fit as an "18 year old" whatever the fuck that means. I too could probably get "fit as an 18 year old" if I were taking steroids like testosterone and exercised every day. Hell, I be you could too, and probably without the testosterone. This is the last guy I'd listen to for longevity treatments.
- selimthegrim 4y ago
  I think rapamycin has some study supporting it
  - nradov 4y ago
    The data on rapamycin (and rapalogs in general) is mixed. There is no reliable evidence that it slows down biological aging in humans. Even if it does have some benefits we don't clearly understand the optimal dosing and schedule. https://peterattiamd.com/mattkaeberlein2/ https://peterattiamd.com/mattkaeberlein2/
  - epistemer 4y ago
    Rapamycin to me is the bat shit crazy aspect of this. There is no research on taking a powerful immunosuppressant pharmaceutical for the next 40 years for "longevity". Not to mention testosterone. At least testosterone will make you feel great while you actually shorten your life in the name of longevity.
  - diydsp 4y ago
    If only some kind of machine could help us figure that out! /s 200+ references in this journal article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
- thisisnico 4y ago
  Honestly he's got some obsessive issues here. Mental health issues that he's willing to try anything to be younger. He doesn't look young in the face and very little can change that. He must be very insecure about it. The sad this is that the doctors see money, and with that much money people won't tell you no if you have terrible ideas.
  - pyrophane 4y ago
    People will go to extraordinary lenghts to avoid having to confront their own mortality.
- 4y ago
nunez 4y ago
Wow, this is sad.

toomuchtodo 4y ago

These help, but genetics also play part. You can’t lifestyle your way out of bad genetics.

nradov 4y ago
To a limited extent you can medicate yourself out of some bad genetics. Statins and anti-hypertensives have really changed the game.

malfist 4y ago

Jesus why is he on so many diabetic meds? He's on metformin, taking 1500mg in the morning of an extended release, and 500mg extended release in the evening. Normal dosage for this is 500mg/day. Extended release means they stay in his system for 24 hours, no reason to take it in two doses, much less take 4x the normal amount. He's also on Acarbose, another diabetic med. The recommended dosing for this is 50mg 3 times per day and hes' taking two 200mg doses. This makes no sense, your body eliminates it quickly, halflife of 2 hours. It's also 6x the standard dose. He's also on Rapamycin, a cancer med or organ transplant med that is immunosupressive. Standard dose is 2mg/day. He's taking 13mg twice a week. He's also taking Testesterone 6 of 7 days of the week, and half your standard does. Total nonsense. This guy is going to wreck his kidney and liver with these meds, put himself at high risk of infection and disrupt his endocrine system. And that's just with his prescriptions, not even examining his supplements. All this to brag that he's as fit as an "18 year old" whatever the fuck that means. I too could probably get "fit as an 18 year old" if I were taking steroids like testosterone and exercised every day. Hell, I be you could too, and probably without the testosterone. This is the last guy I'd listen to for longevity treatments.

selimthegrim 4y ago
I think rapamycin has some study supporting it
- nradov 4y ago
  The data on rapamycin (and rapalogs in general) is mixed. There is no reliable evidence that it slows down biological aging in humans. Even if it does have some benefits we don't clearly understand the optimal dosing and schedule. https://peterattiamd.com/mattkaeberlein2/ https://peterattiamd.com/mattkaeberlein2/
- epistemer 4y ago
  Rapamycin to me is the bat shit crazy aspect of this. There is no research on taking a powerful immunosuppressant pharmaceutical for the next 40 years for "longevity". Not to mention testosterone. At least testosterone will make you feel great while you actually shorten your life in the name of longevity.
- diydsp 4y ago
  If only some kind of machine could help us figure that out! /s 200+ references in this journal article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
thisisnico 4y ago
Honestly he's got some obsessive issues here. Mental health issues that he's willing to try anything to be younger. He doesn't look young in the face and very little can change that. He must be very insecure about it. The sad this is that the doctors see money, and with that much money people won't tell you no if you have terrible ideas.
- pyrophane 4y ago
  People will go to extraordinary lenghts to avoid having to confront their own mortality.
4y ago

nunez 4y ago

Wow, this is sad.