5 ms·

I think its a cool theory and seems the most reasonable from all the other theories of aging. However I am a bit disappointed when I only see David's name on ev

I think its a cool theory and seems the most reasonable from all the other theories of aging. However I am a bit disappointed when I only see David's name on every paper published on this topic. Why dont other institutions start similar studies to verify this claim?

rdpfeffer 4y ago
I assume the time to publish is too long, and the research too expensive. Aging takes time. Hopefully this changes soon.
- oneoff786 4y ago
  Coming soon, on-demand aging.
  - 1970-01-01 4y ago
    YC 2043: Aging as a service. AaaS.
    - molotovh 4y ago
      I mean ... they literally talk about the potential ability to force the aging process backward or forward in the abstract, so... haha.
      - oneoff786 4y ago
        Expedient prisons then. No need to serve time. You just lose 30 years on the spot.
carbocation 4y ago
Some say that there are issues with this and related works. https://twitter.com/charlesmbrenner/status/1613581757634457602 https://twitter.com/charlesmbrenner/status/16135817576344576...
- rafaelero 4y ago
  I always see this guy antagonizing everyone (David Sinclair, Aubrey de Grey, etc.). Is he the Gary Marcus of longevity?
- DennisP 4y ago
  So he's saying they didn't fix aging, they just fixed some simpler damage they did themselves. But in a previous experiment, the same treatment improved aging damage to the vision of actually old mice: > Sinclair and colleagues injected the reprogramming-factor genes into the eyes of 1-year-old healthy mice, roughly the mouse equivalent of middle-age. By this stage, the animals had visual acuity scores about 15% lower than their 5-month-old counterparts. Four weeks after treatment, older mice had similar acuity scores to younger ones. https://www.science.org/content/article/researchers-restore-lost-sight-mice-offering-clues-reversing-aging https://www.science.org/content/article/researchers-restore-...
bpodgursky 4y ago
All the top postdocs would rather work at the well-known lab with lots of grant money and experience. I'm sure someone else is trying, but there's an agglomerative effect here, where a competing lab would be starting at a disadvantage and playing with a B-team.
fallingfrog 4y ago
This is exactly the technology Altos labs is working on, and they have 4 nobel laureates on their staff. There are other companies too. There's going to be an explosion of progress in the next few years.

rdpfeffer 4y ago

I assume the time to publish is too long, and the research too expensive. Aging takes time. Hopefully this changes soon.

oneoff786 4y ago
Coming soon, on-demand aging.
- 1970-01-01 4y ago
  YC 2043: Aging as a service. AaaS.
  - molotovh 4y ago
    I mean ... they literally talk about the potential ability to force the aging process backward or forward in the abstract, so... haha.
    - oneoff786 4y ago
      Expedient prisons then. No need to serve time. You just lose 30 years on the spot.

carbocation 4y ago

Some say that there are issues with this and related works. https://twitter.com/charlesmbrenner/status/1613581757634457602 https://twitter.com/charlesmbrenner/status/16135817576344576...

rafaelero 4y ago
I always see this guy antagonizing everyone (David Sinclair, Aubrey de Grey, etc.). Is he the Gary Marcus of longevity?
DennisP 4y ago
So he's saying they didn't fix aging, they just fixed some simpler damage they did themselves. But in a previous experiment, the same treatment improved aging damage to the vision of actually old mice: > Sinclair and colleagues injected the reprogramming-factor genes into the eyes of 1-year-old healthy mice, roughly the mouse equivalent of middle-age. By this stage, the animals had visual acuity scores about 15% lower than their 5-month-old counterparts. Four weeks after treatment, older mice had similar acuity scores to younger ones. https://www.science.org/content/article/researchers-restore-lost-sight-mice-offering-clues-reversing-aging https://www.science.org/content/article/researchers-restore-...

bpodgursky 4y ago

All the top postdocs would rather work at the well-known lab with lots of grant money and experience. I'm sure someone else is trying, but there's an agglomerative effect here, where a competing lab would be starting at a disadvantage and playing with a B-team.

fallingfrog 4y ago

This is exactly the technology Altos labs is working on, and they have 4 nobel laureates on their staff. There are other companies too. There's going to be an explosion of progress in the next few years.