3 ms·
These drugs positively impact indicators of these things in everyone. I think people's eagerness to jump from changes in markers to actual longevity is quite u
by joe_the_user 4y ago
These drugs positively impact indicators of these things in everyone.
I think people's eagerness to jump from changes in markers to actual longevity is quite unfortunate. Medical "breakthroughs" often founder on such confusion and amateurs approaching things this way. See Goodhart's Law [1] (much as I generally regret the hn/geek tendency to lean these law, here it's reasonable).
https://en.wikipedia.org/wiki/Goodhart%27s_law https://en.wikipedia.org/wiki/Goodhart%27s_law
- zerocrates 4y agoSomewhat inevitable to use surrogates because you're going to take absolutely forever to get results on longevity (barring things with very strong negative effects on longevity). Though communicating the difference between things that are only proven on surrogate markers and things shown to actually affect the real desired outcome is important, I agree.