3 ms·

You really need to suppress appetite rather than avoid hunger. How many have of us have eaten despite not being hungry?

by psychphysic 4y ago

tptacek 4y ago
That's what these drugs do.
- psychphysic 4y ago
  You're probably right the common side effects are all reason to not eat (nausea, GI upset).
  - tptacek 4y ago
    The other effects (they're not a side effects, since they're the intended effects) are satiety and cessation of cravings. In the "appetite vs. hunger" dichotomy you set up, the drugs seem to be addressing mostly the former; in fact, it sounds like, from reports on this thread, pts on these meds very much still experience true hunger symptoms (weakness, headache, brain fog).
    - psychphysic 4y ago
      In the UK at least semiglutide is licensed only for diabetes. So it's appetite suppression is a side effect. That's good because it means it gets reported. Looking at the SPC[0] we can see decreased appetite is "common" (1~10%), while nausea is "very common"(>10% report). That means more people feel nauseated on semiglutide than feel less hungry. Add in other GI disturbances (diarrhoea is also "very common") and one can see why people lose weight with it. [0] https://www.medicines.org.uk/emc/product/9750/smpc https://www.medicines.org.uk/emc/product/9750/smpc
      - nostrebored 4y ago
        Very weird to take a country that hasn’t kept pace with research here and use it as representative, especially with a sample of patients with chronic disease. Having been on semaglutide, it both makes you feel full with smaller portions and changes what you want to eat. The foods which make you feel nauseous are those that make you gain weight. However the change in desire isn’t only against foods which make you feel nauseous, but also towards foods that you might not eat. It’s truly very interesting.
      - tedunangst 4y ago
        Are patients equally likely to reliably report appetite suppression and nausea?

You really need to suppress appetite rather than avoid hunger. How many have of us have eaten despite not being hungry?

tptacek 4y ago

That's what these drugs do.

psychphysic 4y ago
You're probably right the common side effects are all reason to not eat (nausea, GI upset).
- tptacek 4y ago
  The other effects (they're not a side effects, since they're the intended effects) are satiety and cessation of cravings. In the "appetite vs. hunger" dichotomy you set up, the drugs seem to be addressing mostly the former; in fact, it sounds like, from reports on this thread, pts on these meds very much still experience true hunger symptoms (weakness, headache, brain fog).
  - psychphysic 4y ago
    In the UK at least semiglutide is licensed only for diabetes. So it's appetite suppression is a side effect. That's good because it means it gets reported. Looking at the SPC[0] we can see decreased appetite is "common" (1~10%), while nausea is "very common"(>10% report). That means more people feel nauseated on semiglutide than feel less hungry. Add in other GI disturbances (diarrhoea is also "very common") and one can see why people lose weight with it. [0] https://www.medicines.org.uk/emc/product/9750/smpc https://www.medicines.org.uk/emc/product/9750/smpc
    - nostrebored 4y ago
      Very weird to take a country that hasn’t kept pace with research here and use it as representative, especially with a sample of patients with chronic disease. Having been on semaglutide, it both makes you feel full with smaller portions and changes what you want to eat. The foods which make you feel nauseous are those that make you gain weight. However the change in desire isn’t only against foods which make you feel nauseous, but also towards foods that you might not eat. It’s truly very interesting.
    - tedunangst 4y ago
      Are patients equally likely to reliably report appetite suppression and nausea?