> The AI might have solved structures according to the rules it’s been told, Wanna know how I know you don't know how that stuff works? You don't tell these t

> The AI might have solved structures according to the rules it’s been told, Wanna know how I know you don't know how that stuff works? You don't tell these things rules. At all. Nothing even slightly resembling that happens at any point in the process. That's kind of the whole point of machine learning. > but are they accurate with what happens in reality? For any given protein, AlphaFold usually predicts a structure very close to what you get for the isolated protein from crystallography or cryo-EM or whatever. It massively outperforms computational chemistry or any other "rules-based" system. Does it predict every conformation a protein might adopt in vivo? No. But those are not "protein structures known to biology", because guess where biology gets its "known" structures? It does predict the known structures. Yes, including ones that weren't in its training data.