3 ms·

Now explain how it could affect Alzheimers

• WaxProlix 4y ago
  > some anti-inflammatory properties https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214864/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214864/ Lots of literature 1 google/ddg search away for you, but there's an example.
• deleted 4y ago
  [deleted]
• maerF0x0 4y ago
  >We additionally show that HCQ exerts dose-dependent effects on late long-term potentiation (LTP) and rescues impaired hippocampal synaptic plasticity prior to significant accumulation of amyloid plaques and neurodegeneration in APP/PS1 mice. iirc (I am not qualified!!) Alzheimers relates to plaques in our brain, and this sounds to me like it fixes a precursor to the plaque accumulation (the loss of plasticity?)
  • pelorat 4y ago
    The plaques are a side effect of something we don't understand yet. Treating the plaque or slowing it is not a solution, we need to find and fix the cause.
    • emodendroket 4y ago
      Quite apart from the validity of this study, isn’t a purely palliative measure still valuable?
      • mattkrause 4y ago
        Literally billions of dollars has been spent, futilely, on the idea that removing plaques would stop/reverse the symptoms of Alzheimer's Disease. This "amyloid hypothesis" has not been a smashing success, to put in mildly.
      • ummonk 4y ago
        It's not clear that treating amyloid plaque is actually palliative for Alzheimer's patients.
• api 4y ago
  Being anti-inflammatory?