6 ms·

For some context from someone who's been on that Res, its population is highly vulnerable with no margin for mishaps. It's a place of generational, crushing pov

For some context from someone who's been on that Res, its population is highly vulnerable with no margin for mishaps. It's a place of generational, crushing poverty, crime, illness, genetic-exacerbated substance abuse, broad lack of economic opportunity, cultural isolation, and federal disinvestment. Free federal healthcare is available, but only at an IHS hospital in Rapid City 1.5 hours away in good weather: it's antiquated and maximally bureaucratic and probably lower standards of care than your vet provides. The local Habitat for Humanity chapter (I served on their board) tried to help them with community housing efforts, but houses were always gutted of all fixtures before completion. IMO, at a minimum, the IHS (and the VA) need to merge under Medicare for standardization, availability, and economics of scale and industry needs incentives to bring employment opportunities (I think Cisco tried once and bailed).

Ntrails 4y ago
> genetic-exacerbated substance abuse Could you expand on this a bit? Not a concept I am familiar with
- dboreham 4y ago
  Not parent, but this is a generally accepted thing, e.g. https://www.bumc.bu.edu/genetics/research/substance-abuse/ https://www.bumc.bu.edu/genetics/research/substance-abuse/
  - ffssffss 4y ago
    That paper also seems to heavily qualify the findings, implying that environmental factors may dominate genetic ones (or may not, the point is that we don't know): However, these loci explain only a small proportion of the genetic variance. The “missing heritability” may be explained by other genetic mechanisms and gene*environment interactions
- boomboomsubban 4y ago
  https://en.wikipedia.org/wiki/Alcohol_and_Native_Americans#Genetic_predisposition_to_alcoholism https://en.wikipedia.org/wiki/Alcohol_and_Native_Americans#G... Alcoholism rates among Native Americans is higher than most groups, which leads some to suspect a genetic reason. Currently, there isn't a ton of evidence supporting that idea.
  - imoverclocked 4y ago
    There is also severe distrust of western medicine and science in many Native American communities which makes doing studies hard.
  - Ntrails 4y ago
    I knew about the alcoholism rates, but had always assumed it was a socio-economic / situational driven thing. I understand that historically it was used in some sense to control and indeed damage the Native Americans by the colonists? To what extent alcohol was completely new etc I do not know
    - boomboomsubban 4y ago
      >To what extent alcohol was completely new etc I do not know Kind of a tricky question that is somewhat covered in my link. Alcohol was definitely brewed in the Americas pre-Columbus, but by the seventeenth century alcohol was largely unknown to the Natives interacting with the colonists.
      - amanaplanacanal 4y ago
        I always wonder how much was lost in the population crash caused by the introduction of old world diseases.
      - LarsDu88 4y ago
        Tejuino is a precolonial alcoholic beverage that is still enjoyed today. It's ABV is incredibly low compared to anything you'd buy in a modern 7/11 however. The tarahumara people's have more alcoholic version called tesguino that is only drunk once per year as the preparation process is labor intensive, and the drink goes bad rather quickly
- aaomidi 4y ago
  Not exactly what you’re asking but there’s also a concept of genetic trauma, where some traumas can fundamentally change your offspring. For example, your grandmother from your moms side technically made the egg cells that you were born from. That means that whatever your grandmother was going through could for example pass on all the way down to you.
  - phkahler 4y ago
    >> For example, your grandmother from your moms side technically made the egg cells that you were born from. That can't be right. Grandma gave mom a single cell. Mom's ovaries with grandpa's DNA too produced the egg leading to me. Or is there some element I'm not aware of that make it more like stated above?
    - soVeryTired 4y ago
      I guess the egg cell you came from was made inside your grandma when your mom was an embryo in her. So the the cell was technically made inside your grandma’s body.
      - abledon 4y ago
        isn't the mother just providing the nourishment for the fetus to grow inside her? and the fetus itself, takes the nourishment, and actually producing the eggs inside itself? So technically I don't think we can say the grandma is making the eggs directly, but has assisted in the fetus' creation, and then provided the nutrients/environment for the egg creation that the fetus itself makes (which yes, can influence things w/ the generational trauma science coming out...).
        rolph 4y ago
        mom and dad also supply a half helix [single strand] of DNA, with conservation of state. this passes on the structural features responsible for regulatory configuration
    - 4y ago
- citizenpaul 4y ago
  > genetic-exacerbated substance abuse >Could you expand on this a bit? Not a concept I am familiar with Its profitable to pretend that personal choices have nothing to do with drug addiction. Then you can "treat" them forever collecting a monthly check from the government. I say this having grown up in a drug house and leaving as a 16yo teenager with nothing. I already regret this comment not because it isn't true but people detached from reality are going to get all bent out of shape.
  - drno123 4y ago
    I know what you mean. Unfortunately, I can only give your comment a single upvote
  - brookst 4y ago
    > Its profitable to pretend that personal choices have nothing to do with drug addiction That is true, and there are systemic issues we should fix. However it is also true that some people will latch on to anything — “personal choices”, “systemic issues” — to justify callousness and lack of compassion. It’s an ugly way to live, always looking for some justification to spit on those who are in already in trouble.
- gedy 4y ago
  Not the OP, but I think a larger factor here is fetal alcohol exposure, not epigenetics.
- _dain_ 4y ago
  populations differ in how well they can handle booze. this has been known since Roman times; various authors wrote how the Germans were more prone to alcoholism than Latins, an ethnic difference that persists to this day. native americans have it particularly bad, and have for centuries. colonist traders exploited it for profit, missionaries tried to stamp it out, Indian leaders often campaigned to keep rum out of their territories, etc.
- imglorp 4y ago
  There are definitely some social/environmental factors but there's enough anecdotal smoke around a genetic predisposition in some populations that the search for fire and causation is underway. https://pubmed.ncbi.nlm.nih.gov/9603607/ https://pubmed.ncbi.nlm.nih.gov/9603607/ https://pubmed.ncbi.nlm.nih.gov/30852706/ https://pubmed.ncbi.nlm.nih.gov/30852706/
BizarroLand 4y ago
Also, Pine Ridge is literally the poorest location in America and the only way out of the poverty is to leave, which means leaving behind your family, your tribe, and your culture. There's like 25 businesses there for a population of thousands. There's no good reason for people to drive through the reservation, a few handfuls of trucks, and the land isn't good for much other than to look at or feed some cows.

Ntrails 4y ago

> genetic-exacerbated substance abuse Could you expand on this a bit? Not a concept I am familiar with

dboreham 4y ago
Not parent, but this is a generally accepted thing, e.g. https://www.bumc.bu.edu/genetics/research/substance-abuse/ https://www.bumc.bu.edu/genetics/research/substance-abuse/
- ffssffss 4y ago
  That paper also seems to heavily qualify the findings, implying that environmental factors may dominate genetic ones (or may not, the point is that we don't know): However, these loci explain only a small proportion of the genetic variance. The “missing heritability” may be explained by other genetic mechanisms and gene*environment interactions
boomboomsubban 4y ago
https://en.wikipedia.org/wiki/Alcohol_and_Native_Americans#Genetic_predisposition_to_alcoholism https://en.wikipedia.org/wiki/Alcohol_and_Native_Americans#G... Alcoholism rates among Native Americans is higher than most groups, which leads some to suspect a genetic reason. Currently, there isn't a ton of evidence supporting that idea.
- imoverclocked 4y ago
  There is also severe distrust of western medicine and science in many Native American communities which makes doing studies hard.
- Ntrails 4y ago
  I knew about the alcoholism rates, but had always assumed it was a socio-economic / situational driven thing. I understand that historically it was used in some sense to control and indeed damage the Native Americans by the colonists? To what extent alcohol was completely new etc I do not know
  - boomboomsubban 4y ago
    >To what extent alcohol was completely new etc I do not know Kind of a tricky question that is somewhat covered in my link. Alcohol was definitely brewed in the Americas pre-Columbus, but by the seventeenth century alcohol was largely unknown to the Natives interacting with the colonists.
    - amanaplanacanal 4y ago
      I always wonder how much was lost in the population crash caused by the introduction of old world diseases.
    - LarsDu88 4y ago
      Tejuino is a precolonial alcoholic beverage that is still enjoyed today. It's ABV is incredibly low compared to anything you'd buy in a modern 7/11 however. The tarahumara people's have more alcoholic version called tesguino that is only drunk once per year as the preparation process is labor intensive, and the drink goes bad rather quickly
aaomidi 4y ago
Not exactly what you’re asking but there’s also a concept of genetic trauma, where some traumas can fundamentally change your offspring. For example, your grandmother from your moms side technically made the egg cells that you were born from. That means that whatever your grandmother was going through could for example pass on all the way down to you.
- phkahler 4y ago
  >> For example, your grandmother from your moms side technically made the egg cells that you were born from. That can't be right. Grandma gave mom a single cell. Mom's ovaries with grandpa's DNA too produced the egg leading to me. Or is there some element I'm not aware of that make it more like stated above?
  - soVeryTired 4y ago
    I guess the egg cell you came from was made inside your grandma when your mom was an embryo in her. So the the cell was technically made inside your grandma’s body.
    - abledon 4y ago
      isn't the mother just providing the nourishment for the fetus to grow inside her? and the fetus itself, takes the nourishment, and actually producing the eggs inside itself? So technically I don't think we can say the grandma is making the eggs directly, but has assisted in the fetus' creation, and then provided the nutrients/environment for the egg creation that the fetus itself makes (which yes, can influence things w/ the generational trauma science coming out...).
      - rolph 4y ago
        mom and dad also supply a half helix [single strand] of DNA, with conservation of state. this passes on the structural features responsible for regulatory configuration
  - 4y ago
citizenpaul 4y ago
> genetic-exacerbated substance abuse >Could you expand on this a bit? Not a concept I am familiar with Its profitable to pretend that personal choices have nothing to do with drug addiction. Then you can "treat" them forever collecting a monthly check from the government. I say this having grown up in a drug house and leaving as a 16yo teenager with nothing. I already regret this comment not because it isn't true but people detached from reality are going to get all bent out of shape.
- drno123 4y ago
  I know what you mean. Unfortunately, I can only give your comment a single upvote
- brookst 4y ago
  > Its profitable to pretend that personal choices have nothing to do with drug addiction That is true, and there are systemic issues we should fix. However it is also true that some people will latch on to anything — “personal choices”, “systemic issues” — to justify callousness and lack of compassion. It’s an ugly way to live, always looking for some justification to spit on those who are in already in trouble.
gedy 4y ago
Not the OP, but I think a larger factor here is fetal alcohol exposure, not epigenetics.
_dain_ 4y ago
populations differ in how well they can handle booze. this has been known since Roman times; various authors wrote how the Germans were more prone to alcoholism than Latins, an ethnic difference that persists to this day. native americans have it particularly bad, and have for centuries. colonist traders exploited it for profit, missionaries tried to stamp it out, Indian leaders often campaigned to keep rum out of their territories, etc.
imglorp 4y ago
There are definitely some social/environmental factors but there's enough anecdotal smoke around a genetic predisposition in some populations that the search for fire and causation is underway. https://pubmed.ncbi.nlm.nih.gov/9603607/ https://pubmed.ncbi.nlm.nih.gov/9603607/ https://pubmed.ncbi.nlm.nih.gov/30852706/ https://pubmed.ncbi.nlm.nih.gov/30852706/

BizarroLand 4y ago

Also, Pine Ridge is literally the poorest location in America and the only way out of the poverty is to leave, which means leaving behind your family, your tribe, and your culture. There's like 25 businesses there for a population of thousands. There's no good reason for people to drive through the reservation, a few handfuls of trucks, and the land isn't good for much other than to look at or feed some cows.