8 ms·

THC and CBD improve wound healing, may be valuable as skin rejuvenators, study

86 points by hericium 4y ago

h2odragon 4y ago
Harvesting cannabis flower involves cutting the individual buds off the stems, cutting off leaves, etc. Close handling. Of generally annoyingly sticky stuff, with sharp scissors. There are often many minor cuts and nicks and scrapes on the fingers in the process. They rarely tend to be serious, but now I think about it they're not as annoying as papercuts. Suspect the mechanical "wound glue" action of the resins is more important immediately; and the fact that they pretty much only wash off with alcohol means the wounds are disinfected then too.
- latchkey 4y ago
  I spent years cleaning hundreds of pounds of weed (1 lb == ~8-10 hours of cleaning, if you're doing it well). Never once cut myself with scissors. I also used canola or coconut oil to clean the resin off as that worked really well and was an inexpensive way to do it (and seems better than pouring alcohol all over your skin... which would cause it to absorb even more of the resin). Just don't get your hands wet before you put the oil on. Even though the resin is oil based, you definitely absorb it into your skin. Hours of trimming turns into a spin.
  - realce 4y ago
    > I also used canola or coconut oil to clean Ooo that's a great tip, thanks.
- encryptluks2 4y ago
  Your hands don't get saturated in resin unless you're doing something wrong, like squeezing the buds trying to drain oil by hand. It would take a extremely bad trimmer to be continually cutting themselves while trimming. There are a lot of components to THC and CBD that could have beneficial properties, not just the fact that they are naturally sticky.
  - latchkey 4y ago
    My hands would absolutely get covered, but then again the stuff I was trimming was really great quality. ;-) Looking at it under a magnifying glass, all the nodules were wet glimmering, it was impossible to not get it everywhere.
nking 4y ago
- Joker_vD 4y ago
  Well, I'd say it's still marginally better than tar water (which too used to be widely praised).
  - RajT88 4y ago
    I always go back to this one which I saw a while back: https://www.bustle.com/articles/41125-one-night-cough-syrup-and-other-typical-drugstore-items-that-used-to-be-laced-with-illicit https://www.bustle.com/articles/41125-one-night-cough-syrup-...
    - Joker_vD 4y ago
      I vaguely remember reading somewhere that not only opiates are effective cough suppressants, they're in fact pretty much the only known effective cough suppressants, all other tried non-opiates being only very slightly better than placebo. Could be wrong, of course.
      - the_only_law 4y ago
        DXM? I’ve heard the only reason it’s OTC in the US is because the alternative are opioids.
        zoklet-enjoyer 4y ago
        Low dose of DXM and codeine is the best cough suppressant
        Joker_vD 4y ago
        Well, duh: codeine is a great cough suppresant; it's also an opiate.
danbruc 4y ago
Somewhat related, cannabis might not actually help to relieve pain. [1] [1] https://www.health.harvard.edu/blog/does-cannabis-actually-relieve-pain-or-is-something-else-going-on-202212082863 https://www.health.harvard.edu/blog/does-cannabis-actually-r...
- bitxbitxbitcoin 4y ago
  Acute pain - not chronic pain.
  - zaps 4y ago
    What about adorable pain
  - MagicMoonlight 4y ago
    So that would suggest chronic pain isn't real and they just want drugs
    - monetus 4y ago
      Please don't troll
- scythe 4y ago
  If you look at the actual paper there: https://pubmed.ncbi.nlm.nih.gov/36441553/ https://pubmed.ncbi.nlm.nih.gov/36441553/ you will notice that "studies were excluded if they treated patients with [...] severe skin disorders". Which seems relevant in integrating those findings with these.
ltbarcly3 4y ago
I heard snake oil is really good for your skin. I wonder if there are any unreplicated studies funded by snake oil manufacturers that we should vote onto the front-page like morons? (You can check easily that this was funded by manufacturers of cannabis beauty products via MITACS)
- chitowneats 4y ago
  Maybe I missed it, but where in this study does it state that the authors are involved in the manufacturing or processing of cannabis? Edit: Thanks. I wasn't familiar with MITACS. It does look like they exist to assist industry funding of studies like this.
- SuoDuanDao 4y ago
  I wish people had this kind of skepticism around research by larger pharmaceutical companies.
onnnon 4y ago
I've personally used hash oil (aka Rick Simpson oil) on wounds, and it works wonders. https://en.wikipedia.org/wiki/Hash_oil https://en.wikipedia.org/wiki/Hash_oil
- jjtheblunt 4y ago
  Have you compared it to Aloe, or some control? I wonder because there used to be a "wormwood oil" from some other plant that I used as a kid and, like you said, it really was great at healing skin abrasions (cuts, scrapes, kids stuff).
  - onnnon 4y ago
    No, but the linked study looked into wound healing and found it to be effective. This aligns with my personal experience.
  - mandmandam 4y ago
    You know, that seems like a rather easy study to do. Topically apply two compounds to either side of a minor wound and see which side heals faster and better. Seems like with a large enough sample the truth would become clear pretty fast.
smm11 4y ago
Bran cereal was once found to lower cholesterol. What was actually happening was those who ate bran cereal ate less cholesterol-raising foods at the same time.
MagicMoonlight 4y ago
If you're holding a joint, everything looks like it needs one
- bitxbitxbitcoin 4y ago
  Especially if the cannabis cultivar in the joint is 9 lb hammer by Jinxproof Genetics.
BrotherBisquick 4y ago
Sounds like another scientific study that reddit will celebrate while ignoring other scientific studies that make them uncomfortable.
- trap_goes_hot 4y ago
  Its a mistake to think think scientific studies are about establishing facts. Science produces explanations that can be tested. If you never test them, science stops working.
LarryMullins 4y ago
As much as I enjoy cannabis (in moderation of course) I just don't trust any of the medical research surrounding it. The motivation to find medical benefits, to redress the social injustice of people being imprisoned for cannabis, is too strong to ignore. It makes all such research suspect by default as far as I'm concerned. Anecdotally, I have never found cannabis to be effective at pain relief. I tried it, but it only enhanced my perception of the pain (just as it enhances my perception of taste, music, etc...) When I broke my foot I refused any prescriptions and tried a high-CBD strain of cannabis instead, but it made the pain worse. OTC paracetamol/acetaminophen proved far more effective.
- yellow_lead 4y ago
  I experienced something similar, the pain still persists but it's a bit different, maybe more "tingly" in some way. Wasn't better or worse for me though
- the_only_law 4y ago
  > I just don't trust any of the medical research surrounding it. Same, I tried to do some research about the effects of weed on a certain chemical in the body, and every paper I found had some completely different conclusions. I will say the one thing cannabis does for me that’s absolutely amazing is as an anti-emetic/anti nausea remedy. Nothing else I’ve ever tried has come close to relieving those sort of symptoms. It does also seem to work for me as a sleep aid, but in the same way as say, antihistamines do (i.e. I’ll sleep, but I’ll have an intense brain fog the next morning)
  - LarryMullins 4y ago
    > absolutely amazing is as an anti-emetic/anti nausea remedy Agreed, cannabis seems to work great as an anti-nausea remedy. I've also found ginger to be effective for this (wikipedia claims evidence for that is inconclusive, but it definitely works for me.)
  - QuercusMax 4y ago
    This is 100% true. If my guts are feeling weird and preventing me from sleeping / focusing, THC is an almost instant cure.
RandomTisk 4y ago
I've developed a pretty severe allergy to anything cannabis or CBD oil related. It started at the end of 2020 and came out of the blue after taking CBD oil one day. Before that, AFAIK I had no allergy to anything cannabis related. It causes bad respiratory issues for about 48 hours if I consume any and skin hives that take at least a month to fully clear up. I wish I knew what caused my allergy to appear, whether age, COVID, or something in the oil that wasn't supposed to be there perhaps.
- Vrondi 4y ago
  You may be allergic to something on/in it, such as a pesticide or fertilizer perhaps? Especially if it all came from one processor. Did it come from a dispensary?
smrtinsert 4y ago
Didn't they just find that using THC significantly drew out the recovery time after surgery? Caveat emptor.
- mandmandam 4y ago
  Haven't seen that. Link? Bet you they were smoking it, as compared to vaping or eating. Side-bet that they were using isolated THC instead of actual plant. And even if recovery time was extended - what was the subjective experience of the patient? Finally, and perhaps most importantly - every time that cannabis gets legalized, opioid overdoses drop significantly. How many people get hooked on opiates post-surgery every year?
- eurasiantiger 4y ago
  If it’s illegal, people are less likely to move from their apartment, leading to less exercise and longer recovery times.
6stringmerc 4y ago
Uh, the reason I'm not dead because of the Sackler Family's profiteering is because I studied cannabis and know my strains and my doses. 250,000+ Americans dead, 5x that in family suffering, the single first drop in life expectancy for white males in the country in reasonable working age. And go look at the testimony I found from the floor of the House when they passed the original Prohibition if you like naked racism toward Blacks and Latinos. I found it in a library, they still exist. It does work for blood pressure, anxiety, pain management, arthritis management, and just being able to relax and let your body heal. Oh that's right, we have sick-care and a broken fucking system in the US where even maintenance medication (about to be discontinued) was billed at $35,000 a month if you include shipping. I used to get 90 day supplies. Now it's every month. I can only imagine what something newer than 20 years old costs here. Hence I'm happy to have met some Nepalese and will likely travel to the capitol with guidance from a North Texas immigrant peer who shares the love of Guns N Roses and thinks I'd really like it there. Free health care. They speak English. They like music and don't throw people in jail for that plant that grows naturally in their environment. They might not have pets, but pets are a luxury. I'd rather go to a place that can enjoy an evening of food and music more than trying to get together for some cultish sports thing creating regional rivalries that mean abso-fuckin-lutely nothing.
- TurkishPoptart 4y ago
  what meds cost $35,000 a month? agree with you on your points.
  - mmerlin 4y ago
    Maybe those times when a PharmaBro with zero moral compass connived an exclusive supply chain of a previously inexpensive drug nobody else was bothering to make any more, and jacked up the price x10000 for as long as possible to squeeeeeeeze the health system for outlandish profits
hayleyest 4y ago
Having read the study, methodologies, and conclusions: This looks like a wonderful bit of science. I appreciate the stepped approach they took to determining a potential best path forward. I find it exciting how it consistently improved outcomes on the wounds. It's particularly fascinating to me that it works in combination with the hydrogen peroxide, and that helps the process, not hinders it (it hinders it without cbd or thc). Assuming the paper isn't a gigantic fabrication to be retracted or disputed, then this is a rather exciting time. I know many who suffer from skin lesions, and even reducing their healing time by 10% would be miraculous. Steroid creams work wonders too, but the toll it takes on the body is severe after the years pile up.
- constantcrying 4y ago
  Could you explain to me how they arrived at the p values in figure 1? Thank you.
constantcrying 4y ago
I absolutely love how the title suggests a million things more than the study itself. Nothing in the study even could demonstrate any actual therapeutic effects. Even if the study were one hundred percent well done[0][1] and described a real link between wound healing and Cannabis, it's relevance to the question of any actual benefits in actual human is almost zero. At best it is an extremely weak signal. Of course nobody would care about the study if it was somewhat truthfully reported about. Please look at Figure 1 and tell me what they are doing. Are they doing what I think they are doing, are they actually doing the statistical test on the whole sample? Without any controls? Doing NOTHING obviously increases \beta-Gal activity, so of course even a treatment which does NOTHING has a positive effect. Are they actually ignoring that? Are they literally just running random data through a statistics program and get excited because they get out p < 0.0001, because their Null hypothesis isn't "no difference", but "nothing changed", which is obviously ridiculous. Please tell me I am totally wrong.[1] [0] "All anti-aging drugs were dissolved in DMSO and then dissolved in the media before being applied (n = 3 for each condition) for 2 h daily for 5 days." - from section 2.3 in the paper in question. Yes n = 3[2]. [1] I highly recommend reading: https://library.mpib-berlin.mpg.de/ft/gg/GG_Mindless_2004.pdf https://library.mpib-berlin.mpg.de/ft/gg/GG_Mindless_2004.pd... [2] Granted, this isn't as bad as it sound, since they try to measure differences of groups of samples.
LinuxBender 4y ago
One word of caution with CBD's. If you are on any medications that are metabolized by the liver, CBD's can slow the metabolic process in the liver of your RX drugs and in effect amplify them. Quite a large number of people have ended up in the ER due to overdosing on their prescription drugs without actually changing the dose as a result of combining with CBD's. Making this worse is that some doctors do not know this which can prolong the time to stabilize the patient. Here is one of the many discussions on this topic. [1] [1] - https://www.youtube.com/watch?v=QYCkVjdgDqQ https://www.youtube.com/watch?v=QYCkVjdgDqQ [video] [58 minutes]
1MachineElf 4y ago
In my case it helped as a topical treatment for itching/pain caused by severe sunburn/sun poisoning.
bluenose69 4y ago
I don't know anything about this particular MDPI journal, but my experience with other journals published by this group is a bit worrisome. They often (a) ask me to review papers that have nothing to do with my research activity and (b) ask me to be an editor of special issues that, again, are in fields unrelated to my work. I can think of no well-respected journal that does such things. The other side of the coin is that I know of no serious researchers who submit to, or read, MDPI journals, despite the fact that they have some journals that would, based on title alone, be relevant. There is a bit of discussion of whether to consider MDPI a "predatory" publisher at https://en.wikipedia.org/wiki/MDPI https://en.wikipedia.org/wiki/MDPI. None of this need reflect on the paper in question, of course. Perhaps this particular journal is of high quality. And, even if not, perhaps the paper is of high quality.

86 points by hericium 4y ago

Harvesting cannabis flower involves cutting the individual buds off the stems, cutting off leaves, etc. Close handling. Of generally annoyingly sticky stuff, with sharp scissors. There are often many minor cuts and nicks and scrapes on the fingers in the process. They rarely tend to be serious, but now I think about it they're not as annoying as papercuts. Suspect the mechanical "wound glue" action of the resins is more important immediately; and the fact that they pretty much only wash off with alcohol means the wounds are disinfected then too.

latchkey 4y ago
I spent years cleaning hundreds of pounds of weed (1 lb == ~8-10 hours of cleaning, if you're doing it well). Never once cut myself with scissors. I also used canola or coconut oil to clean the resin off as that worked really well and was an inexpensive way to do it (and seems better than pouring alcohol all over your skin... which would cause it to absorb even more of the resin). Just don't get your hands wet before you put the oil on. Even though the resin is oil based, you definitely absorb it into your skin. Hours of trimming turns into a spin.
- realce 4y ago
  > I also used canola or coconut oil to clean Ooo that's a great tip, thanks.
encryptluks2 4y ago
Your hands don't get saturated in resin unless you're doing something wrong, like squeezing the buds trying to drain oil by hand. It would take a extremely bad trimmer to be continually cutting themselves while trimming. There are a lot of components to THC and CBD that could have beneficial properties, not just the fact that they are naturally sticky.
- latchkey 4y ago
  My hands would absolutely get covered, but then again the stuff I was trimming was really great quality. ;-) Looking at it under a magnifying glass, all the nodules were wet glimmering, it was impossible to not get it everywhere.

nking 4y ago

Joker_vD 4y ago
Well, I'd say it's still marginally better than tar water (which too used to be widely praised).
- RajT88 4y ago
  I always go back to this one which I saw a while back: https://www.bustle.com/articles/41125-one-night-cough-syrup-and-other-typical-drugstore-items-that-used-to-be-laced-with-illicit https://www.bustle.com/articles/41125-one-night-cough-syrup-...
  - Joker_vD 4y ago
    I vaguely remember reading somewhere that not only opiates are effective cough suppressants, they're in fact pretty much the only known effective cough suppressants, all other tried non-opiates being only very slightly better than placebo. Could be wrong, of course.
    - the_only_law 4y ago
      DXM? I’ve heard the only reason it’s OTC in the US is because the alternative are opioids.
      - zoklet-enjoyer 4y ago
        Low dose of DXM and codeine is the best cough suppressant
        Joker_vD 4y ago
        Well, duh: codeine is a great cough suppresant; it's also an opiate.

danbruc 4y ago

Somewhat related, cannabis might not actually help to relieve pain. [1] [1] https://www.health.harvard.edu/blog/does-cannabis-actually-relieve-pain-or-is-something-else-going-on-202212082863 https://www.health.harvard.edu/blog/does-cannabis-actually-r...

bitxbitxbitcoin 4y ago
Acute pain - not chronic pain.
- zaps 4y ago
  What about adorable pain
- MagicMoonlight 4y ago
  So that would suggest chronic pain isn't real and they just want drugs
  - monetus 4y ago
    Please don't troll
scythe 4y ago
If you look at the actual paper there: https://pubmed.ncbi.nlm.nih.gov/36441553/ https://pubmed.ncbi.nlm.nih.gov/36441553/ you will notice that "studies were excluded if they treated patients with [...] severe skin disorders". Which seems relevant in integrating those findings with these.

ltbarcly3 4y ago

I heard snake oil is really good for your skin. I wonder if there are any unreplicated studies funded by snake oil manufacturers that we should vote onto the front-page like morons? (You can check easily that this was funded by manufacturers of cannabis beauty products via MITACS)

chitowneats 4y ago
Maybe I missed it, but where in this study does it state that the authors are involved in the manufacturing or processing of cannabis? Edit: Thanks. I wasn't familiar with MITACS. It does look like they exist to assist industry funding of studies like this.
SuoDuanDao 4y ago
I wish people had this kind of skepticism around research by larger pharmaceutical companies.

onnnon 4y ago

I've personally used hash oil (aka Rick Simpson oil) on wounds, and it works wonders. https://en.wikipedia.org/wiki/Hash_oil https://en.wikipedia.org/wiki/Hash_oil

jjtheblunt 4y ago
Have you compared it to Aloe, or some control? I wonder because there used to be a "wormwood oil" from some other plant that I used as a kid and, like you said, it really was great at healing skin abrasions (cuts, scrapes, kids stuff).
- onnnon 4y ago
  No, but the linked study looked into wound healing and found it to be effective. This aligns with my personal experience.
- mandmandam 4y ago
  You know, that seems like a rather easy study to do. Topically apply two compounds to either side of a minor wound and see which side heals faster and better. Seems like with a large enough sample the truth would become clear pretty fast.

smm11 4y ago

Bran cereal was once found to lower cholesterol. What was actually happening was those who ate bran cereal ate less cholesterol-raising foods at the same time.

MagicMoonlight 4y ago

If you're holding a joint, everything looks like it needs one

bitxbitxbitcoin 4y ago
Especially if the cannabis cultivar in the joint is 9 lb hammer by Jinxproof Genetics.

BrotherBisquick 4y ago

Sounds like another scientific study that reddit will celebrate while ignoring other scientific studies that make them uncomfortable.

trap_goes_hot 4y ago
Its a mistake to think think scientific studies are about establishing facts. Science produces explanations that can be tested. If you never test them, science stops working.

LarryMullins 4y ago

As much as I enjoy cannabis (in moderation of course) I just don't trust any of the medical research surrounding it. The motivation to find medical benefits, to redress the social injustice of people being imprisoned for cannabis, is too strong to ignore. It makes all such research suspect by default as far as I'm concerned. Anecdotally, I have never found cannabis to be effective at pain relief. I tried it, but it only enhanced my perception of the pain (just as it enhances my perception of taste, music, etc...) When I broke my foot I refused any prescriptions and tried a high-CBD strain of cannabis instead, but it made the pain worse. OTC paracetamol/acetaminophen proved far more effective.

yellow_lead 4y ago
I experienced something similar, the pain still persists but it's a bit different, maybe more "tingly" in some way. Wasn't better or worse for me though
the_only_law 4y ago
> I just don't trust any of the medical research surrounding it. Same, I tried to do some research about the effects of weed on a certain chemical in the body, and every paper I found had some completely different conclusions. I will say the one thing cannabis does for me that’s absolutely amazing is as an anti-emetic/anti nausea remedy. Nothing else I’ve ever tried has come close to relieving those sort of symptoms. It does also seem to work for me as a sleep aid, but in the same way as say, antihistamines do (i.e. I’ll sleep, but I’ll have an intense brain fog the next morning)
- LarryMullins 4y ago
  > absolutely amazing is as an anti-emetic/anti nausea remedy Agreed, cannabis seems to work great as an anti-nausea remedy. I've also found ginger to be effective for this (wikipedia claims evidence for that is inconclusive, but it definitely works for me.)
- QuercusMax 4y ago
  This is 100% true. If my guts are feeling weird and preventing me from sleeping / focusing, THC is an almost instant cure.

RandomTisk 4y ago

I've developed a pretty severe allergy to anything cannabis or CBD oil related. It started at the end of 2020 and came out of the blue after taking CBD oil one day. Before that, AFAIK I had no allergy to anything cannabis related. It causes bad respiratory issues for about 48 hours if I consume any and skin hives that take at least a month to fully clear up. I wish I knew what caused my allergy to appear, whether age, COVID, or something in the oil that wasn't supposed to be there perhaps.

Vrondi 4y ago
You may be allergic to something on/in it, such as a pesticide or fertilizer perhaps? Especially if it all came from one processor. Did it come from a dispensary?

smrtinsert 4y ago

Didn't they just find that using THC significantly drew out the recovery time after surgery? Caveat emptor.

mandmandam 4y ago
Haven't seen that. Link? Bet you they were smoking it, as compared to vaping or eating. Side-bet that they were using isolated THC instead of actual plant. And even if recovery time was extended - what was the subjective experience of the patient? Finally, and perhaps most importantly - every time that cannabis gets legalized, opioid overdoses drop significantly. How many people get hooked on opiates post-surgery every year?
eurasiantiger 4y ago
If it’s illegal, people are less likely to move from their apartment, leading to less exercise and longer recovery times.

6stringmerc 4y ago

Uh, the reason I'm not dead because of the Sackler Family's profiteering is because I studied cannabis and know my strains and my doses. 250,000+ Americans dead, 5x that in family suffering, the single first drop in life expectancy for white males in the country in reasonable working age. And go look at the testimony I found from the floor of the House when they passed the original Prohibition if you like naked racism toward Blacks and Latinos. I found it in a library, they still exist. It does work for blood pressure, anxiety, pain management, arthritis management, and just being able to relax and let your body heal. Oh that's right, we have sick-care and a broken fucking system in the US where even maintenance medication (about to be discontinued) was billed at $35,000 a month if you include shipping. I used to get 90 day supplies. Now it's every month. I can only imagine what something newer than 20 years old costs here. Hence I'm happy to have met some Nepalese and will likely travel to the capitol with guidance from a North Texas immigrant peer who shares the love of Guns N Roses and thinks I'd really like it there. Free health care. They speak English. They like music and don't throw people in jail for that plant that grows naturally in their environment. They might not have pets, but pets are a luxury. I'd rather go to a place that can enjoy an evening of food and music more than trying to get together for some cultish sports thing creating regional rivalries that mean abso-fuckin-lutely nothing.

TurkishPoptart 4y ago
what meds cost $35,000 a month? agree with you on your points.
- mmerlin 4y ago
  Maybe those times when a PharmaBro with zero moral compass connived an exclusive supply chain of a previously inexpensive drug nobody else was bothering to make any more, and jacked up the price x10000 for as long as possible to squeeeeeeeze the health system for outlandish profits

hayleyest 4y ago

Having read the study, methodologies, and conclusions: This looks like a wonderful bit of science. I appreciate the stepped approach they took to determining a potential best path forward. I find it exciting how it consistently improved outcomes on the wounds. It's particularly fascinating to me that it works in combination with the hydrogen peroxide, and that helps the process, not hinders it (it hinders it without cbd or thc). Assuming the paper isn't a gigantic fabrication to be retracted or disputed, then this is a rather exciting time. I know many who suffer from skin lesions, and even reducing their healing time by 10% would be miraculous. Steroid creams work wonders too, but the toll it takes on the body is severe after the years pile up.

constantcrying 4y ago
Could you explain to me how they arrived at the p values in figure 1? Thank you.

constantcrying 4y ago

I absolutely love how the title suggests a million things more than the study itself. Nothing in the study even could demonstrate any actual therapeutic effects. Even if the study were one hundred percent well done[0][1] and described a real link between wound healing and Cannabis, it's relevance to the question of any actual benefits in actual human is almost zero. At best it is an extremely weak signal. Of course nobody would care about the study if it was somewhat truthfully reported about. Please look at Figure 1 and tell me what they are doing. Are they doing what I think they are doing, are they actually doing the statistical test on the whole sample? Without any controls? Doing NOTHING obviously increases \beta-Gal activity, so of course even a treatment which does NOTHING has a positive effect. Are they actually ignoring that? Are they literally just running random data through a statistics program and get excited because they get out p < 0.0001, because their Null hypothesis isn't "no difference", but "nothing changed", which is obviously ridiculous. Please tell me I am totally wrong.[1] [0] "All anti-aging drugs were dissolved in DMSO and then dissolved in the media before being applied (n = 3 for each condition) for 2 h daily for 5 days." - from section 2.3 in the paper in question. Yes n = 3[2]. [1] I highly recommend reading: https://library.mpib-berlin.mpg.de/ft/gg/GG_Mindless_2004.pdf https://library.mpib-berlin.mpg.de/ft/gg/GG_Mindless_2004.pd... [2] Granted, this isn't as bad as it sound, since they try to measure differences of groups of samples.

LinuxBender 4y ago

One word of caution with CBD's. If you are on any medications that are metabolized by the liver, CBD's can slow the metabolic process in the liver of your RX drugs and in effect amplify them. Quite a large number of people have ended up in the ER due to overdosing on their prescription drugs without actually changing the dose as a result of combining with CBD's. Making this worse is that some doctors do not know this which can prolong the time to stabilize the patient. Here is one of the many discussions on this topic. [1] [1] - https://www.youtube.com/watch?v=QYCkVjdgDqQ https://www.youtube.com/watch?v=QYCkVjdgDqQ [video] [58 minutes]

1MachineElf 4y ago

In my case it helped as a topical treatment for itching/pain caused by severe sunburn/sun poisoning.

bluenose69 4y ago

I don't know anything about this particular MDPI journal, but my experience with other journals published by this group is a bit worrisome. They often (a) ask me to review papers that have nothing to do with my research activity and (b) ask me to be an editor of special issues that, again, are in fields unrelated to my work. I can think of no well-respected journal that does such things. The other side of the coin is that I know of no serious researchers who submit to, or read, MDPI journals, despite the fact that they have some journals that would, based on title alone, be relevant. There is a bit of discussion of whether to consider MDPI a "predatory" publisher at https://en.wikipedia.org/wiki/MDPI https://en.wikipedia.org/wiki/MDPI. None of this need reflect on the paper in question, of course. Perhaps this particular journal is of high quality. And, even if not, perhaps the paper is of high quality.