3 ms·

> Yet, later on the govt did come out with protocols that strangely, mimicked Zelenko & McCullough's material. No no no this is disinformation! A protocol whic

> Yet, later on the govt did come out with protocols that strangely, mimicked Zelenko & McCullough's material. No no no this is disinformation! A protocol which includes *checks notes* Pfizermectin is totally different than a protocol which includes ivermectin. You can't compare the two!

nradov 4y ago
There haven't been any high-quality studies (consistent with evidence-based medicine criteria) which show ivermectin to be clinically effective as an early COVID-19 treatment. If you know of such a study then could you please provide a citation? If by "Pfizermectin" you are referring to Paxlovid, that is not accurate. There are significant biochemical and pharmacokinetic differences between the molecules. https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967 https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlov...
- OrvalWintermute 4y ago
  on Ivermectin the evidence is over the place. Many of the foreign studies definitely show benefit. Many of the other studies don't. It is a real trainwreck. Consequently, I think it is safe to say that this is up in the air. However, the McCullough protocol [1], and the closely related Zelenko protocols were not only about Ivermectin, HCQ, or Zinc, but instead cocktails of drugs with proven efficacy, and an overall approach to treatment prior to hospitalization. Referencing the late 2020 publication: Sanitization Masks hand washing / hand sanitizer Fresh air / Air circulation Negative pressure air isolation Supplements: Zinc with hydroxychloroquine Vitamin D & Vitamin C Antivirals / Antibiotics Quercetin Favipiravir Azithromycin Doxycycline Mono-Clonal antibodies bamlanivimab (MAB) casirivimab and imdevimab (MABs) Anti-Inflammatory Colchicine Corticosteroids budesonide dexamethasone Antiplatelet agents and antithrombotics aspirin heparin Orals - pixaban, rivaroxaban, edoxaban, dabigatran [1] https://www.imrpress.com/journal/RCM/21/4/10.31083/j.rcm.2020.04.264 https://www.imrpress.com/journal/RCM/21/4/10.31083/j.rcm.202...
  - nradov 4y ago
    If the evidence for ivermectin is really "all over the place" then could you please provide a citation? I'm only asking for a single high-quality RCT. Any one will do. The single link you provided is not that.
    - OrvalWintermute 4y ago
      https://ivmmeta.com/ https://ivmmeta.com/ This is why I say it is all over the place. Also, RCTs have significant challenges in them https://academic.oup.com/ejo/article/37/5/457/2599978 https://academic.oup.com/ejo/article/37/5/457/2599978

nradov 4y ago

There haven't been any high-quality studies (consistent with evidence-based medicine criteria) which show ivermectin to be clinically effective as an early COVID-19 treatment. If you know of such a study then could you please provide a citation? If by "Pfizermectin" you are referring to Paxlovid, that is not accurate. There are significant biochemical and pharmacokinetic differences between the molecules. https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967 https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlov...

OrvalWintermute 4y ago
on Ivermectin the evidence is over the place. Many of the foreign studies definitely show benefit. Many of the other studies don't. It is a real trainwreck. Consequently, I think it is safe to say that this is up in the air. However, the McCullough protocol [1], and the closely related Zelenko protocols were not only about Ivermectin, HCQ, or Zinc, but instead cocktails of drugs with proven efficacy, and an overall approach to treatment prior to hospitalization. Referencing the late 2020 publication: Sanitization Masks hand washing / hand sanitizer Fresh air / Air circulation Negative pressure air isolation Supplements: Zinc with hydroxychloroquine Vitamin D & Vitamin C Antivirals / Antibiotics Quercetin Favipiravir Azithromycin Doxycycline Mono-Clonal antibodies bamlanivimab (MAB) casirivimab and imdevimab (MABs) Anti-Inflammatory Colchicine Corticosteroids budesonide dexamethasone Antiplatelet agents and antithrombotics aspirin heparin Orals - pixaban, rivaroxaban, edoxaban, dabigatran [1] https://www.imrpress.com/journal/RCM/21/4/10.31083/j.rcm.2020.04.264 https://www.imrpress.com/journal/RCM/21/4/10.31083/j.rcm.202...
- nradov 4y ago
  If the evidence for ivermectin is really "all over the place" then could you please provide a citation? I'm only asking for a single high-quality RCT. Any one will do. The single link you provided is not that.
  - OrvalWintermute 4y ago
    https://ivmmeta.com/ https://ivmmeta.com/ This is why I say it is all over the place. Also, RCTs have significant challenges in them https://academic.oup.com/ejo/article/37/5/457/2599978 https://academic.oup.com/ejo/article/37/5/457/2599978