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> to understand why so many pregnancies fail and how we might be able to prevent that from happening Are we sure that's a good idea? I've read that one of the

> to understand why so many pregnancies fail and how we might be able to prevent that from happening Are we sure that's a good idea? I've read that one of the reason for early pregnancy failure is that the embryo is not fit enough and it would be a waste of time and resources to commit to it. Another very counterintuitive finding is that if you try to implant embryos in various tissues (brain, liver, ...), the one in which is the hardest is the uterus! Because it's actively fighting against the embryo.

shash 4y ago
The question is why is the embryo not “fit enough”. One way to increase the chance of success is by making the embryo “more fit”, but that requires an understanding of what that definition of fitness is, and that is what I understand this study is about.
- TEP_Kim_Il_Sung 4y ago
- colechristensen 4y ago
  The genetic recombination process often results in failure, shuffling genes around and associated mutations breaks important things and the embryo gets to the point where it can no longer survive. It is sort of the first filter in evolution, surviving the single-cell to infant process.
- nomel 4y ago
  This is making an extreme assumption that miscarriages aren't an expected, or required, phenomenon.
  - shash 4y ago
    No assumptions. Just a different way to study a phenomenon...
pyuser583 4y ago
That might be true, but I know for a fact it’s a truism that doctors tell women to not feel as bad about miscarriages. My wife has had multiple miscarriages, to the point where it’s expected. Until doctors are informed of her history, they always say “the embryo wasn’t healthy enough to survive on its own …” My wife has a number of hormonal issues, but doctors can’t find a single diagnosis. But it’s certainly not weak embryos.
- TEP_Kim_Il_Sung 4y ago
  Could it be nutrition?
  - pyuser583 4y ago
    Not in the generic “eat better” sense. There are some diets that can affect hormones/cycles, but it’s eating special foods, not laying off the ice cream.
    - TEP_Kim_Il_Sung 4y ago
      I was referring to vitamins and minerals kind of nutrition, not dieting. Forming a baby takes ungodly amounts of minerals.
      - nomel 4y ago
        This is not true, in this context. 75% happen within the first two weeks. No excess nutrition is required in that time. Folic acid is important, but someone having multiple miscarriages, under the care of a doctor, will obviously be taking the recommended supplements.
      - hombre_fatal 4y ago
        This sounds like the sort of giddy overfocusing we do when we project a certain lifestyle (usually one we already live, ourself) as a cure-all onto everything else including people we know nothing about. I remember being jacked at 20 years old, eating spinach and egg whites at the university cafeteria, looking somberly around at everyone—who I'm sure didn't do 100 air-squats each day—while they devoured fried chicken strips. I felt bad for them. How many ailments could we fix if everyone did 20 push-ups when they woke up in the morning and then snorted a cup of oatmeal? Real cocksure of myself, I'd shrug and think what a shame. What I'm trying to say is, did OP's wife try doing pull-ups while eating paleo?
anon_123g987 4y ago
- bpodgursky 4y ago
  The OP posted an entirely mainstream hypothesis. Let's not gatekeep and rely on credentialism.
  - mechanical_bear 4y ago
    Certain gates need to be kept. Not all gatekeeping is bad.
  - alexvoda 4y ago
    First of all, it is a hypothesis even if mainstream. What if pregnancy failure has nothing to do with fitness? At this point we do not yet know. Now explain why we should remain unknowing instead of spending effort to find out.
    - tgv 4y ago
      What good is finding it out anyway? First, we don't know how to define fitness, and certainly not how to measure it in an embryo. All we have is a bunch of genes that correlate with known diseases. Suppose they find that 24.7% of miscarriages arise because of some other reason than fitness. Fixing that before pregnancy will probably require substantial intervention, where that is not needed at all: in most cases, subsequent pregnancies are successful. Knowing what causes miscarriage in other cases is only there to satisfy curiosity. It has no practical application whatsoever. However, the dark side is clearly there, and is what sponsors this kind of research: creating artificial life.
seydor 4y ago
Presumably if they understand the whole process they can move it outside the body in a controlled and non-rejecting artifical womb

shash 4y ago

The question is why is the embryo not “fit enough”. One way to increase the chance of success is by making the embryo “more fit”, but that requires an understanding of what that definition of fitness is, and that is what I understand this study is about.

TEP_Kim_Il_Sung 4y ago
colechristensen 4y ago
The genetic recombination process often results in failure, shuffling genes around and associated mutations breaks important things and the embryo gets to the point where it can no longer survive. It is sort of the first filter in evolution, surviving the single-cell to infant process.
nomel 4y ago
This is making an extreme assumption that miscarriages aren't an expected, or required, phenomenon.
- shash 4y ago
  No assumptions. Just a different way to study a phenomenon...

pyuser583 4y ago

That might be true, but I know for a fact it’s a truism that doctors tell women to not feel as bad about miscarriages. My wife has had multiple miscarriages, to the point where it’s expected. Until doctors are informed of her history, they always say “the embryo wasn’t healthy enough to survive on its own …” My wife has a number of hormonal issues, but doctors can’t find a single diagnosis. But it’s certainly not weak embryos.

TEP_Kim_Il_Sung 4y ago
Could it be nutrition?
- pyuser583 4y ago
  Not in the generic “eat better” sense. There are some diets that can affect hormones/cycles, but it’s eating special foods, not laying off the ice cream.
  - TEP_Kim_Il_Sung 4y ago
    I was referring to vitamins and minerals kind of nutrition, not dieting. Forming a baby takes ungodly amounts of minerals.
    - nomel 4y ago
      This is not true, in this context. 75% happen within the first two weeks. No excess nutrition is required in that time. Folic acid is important, but someone having multiple miscarriages, under the care of a doctor, will obviously be taking the recommended supplements.
    - hombre_fatal 4y ago
      This sounds like the sort of giddy overfocusing we do when we project a certain lifestyle (usually one we already live, ourself) as a cure-all onto everything else including people we know nothing about. I remember being jacked at 20 years old, eating spinach and egg whites at the university cafeteria, looking somberly around at everyone—who I'm sure didn't do 100 air-squats each day—while they devoured fried chicken strips. I felt bad for them. How many ailments could we fix if everyone did 20 push-ups when they woke up in the morning and then snorted a cup of oatmeal? Real cocksure of myself, I'd shrug and think what a shame. What I'm trying to say is, did OP's wife try doing pull-ups while eating paleo?

anon_123g987 4y ago

bpodgursky 4y ago
The OP posted an entirely mainstream hypothesis. Let's not gatekeep and rely on credentialism.
- mechanical_bear 4y ago
  Certain gates need to be kept. Not all gatekeeping is bad.
- alexvoda 4y ago
  First of all, it is a hypothesis even if mainstream. What if pregnancy failure has nothing to do with fitness? At this point we do not yet know. Now explain why we should remain unknowing instead of spending effort to find out.
  - tgv 4y ago
    What good is finding it out anyway? First, we don't know how to define fitness, and certainly not how to measure it in an embryo. All we have is a bunch of genes that correlate with known diseases. Suppose they find that 24.7% of miscarriages arise because of some other reason than fitness. Fixing that before pregnancy will probably require substantial intervention, where that is not needed at all: in most cases, subsequent pregnancies are successful. Knowing what causes miscarriage in other cases is only there to satisfy curiosity. It has no practical application whatsoever. However, the dark side is clearly there, and is what sponsors this kind of research: creating artificial life.

seydor 4y ago

Presumably if they understand the whole process they can move it outside the body in a controlled and non-rejecting artifical womb