I have sub 5ms latency with my RME sound card, could probably go lower. What will hurt after a long while is the bandwidth at 192khz plus some other protocol on

I have sub 5ms latency with my RME sound card, could probably go lower. What will hurt after a long while is the bandwidth at 192khz plus some other protocol on top (clock syncing, midi…). But we’re speaking of more than 64 channel in AND out. So USB is pretty good, and for most sound card, USB2 is enough. Otherwise you can go Thunderbolt, which offer on par experience with PCIe. What a consumer sound card offer now a day is better dac compare to the one of your motherboard or better output for headset.