3 ms·

Yes, there are clear biological markers related to reported symptoms of Long COVID. Increases in exhausted immune T cells and lower levels of cortisol. Also,

Yes, there are clear biological markers related to reported symptoms of Long COVID. Increases in exhausted immune T cells and lower levels of cortisol. Also, patient reported outcomes alone are sufficient to identify Long COVID patients with ~90% accuracy. https://twitter.com/VirusesImmunity/status/1557394192225157122 https://twitter.com/VirusesImmunity/status/15573941922251571... https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1 https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v...

timr 4y ago
Take this paper with a huge grain of salt. They went on a fishing expedition, then pointed an ML model at the data and reported some clusters. This is...questionable methodology. ML models will find a way to draw a discriminatory boundary for almost any classification problem. On the other hand, there was this paper [1][2] from the NIH, which was a well-controlled, pre-registered cohort study, did pretty much every clinical test imaginable (about 150 different measurements per person), and found no measurable differences between "long covid" people and controls. This is a much better study, and rebuts the claim. [1] https://www.medpagetoday.com/infectiousdisease/covid19/98885?xid=nl_mpt_DHE_2022-05-23&eun=g1662251d0r https://www.medpagetoday.com/infectiousdisease/covid19/98885... [2] https://www.acpjournals.org/doi/10.7326/M21-4905 https://www.acpjournals.org/doi/10.7326/M21-4905
- belltaco 4y ago
  People with Long COVID May Still Have Spike Proteins in Their Blood https://www.scientificamerican.com/article/people-with-long-covid-may-still-have-spike-proteins-in-their-blood1/ https://www.scientificamerican.com/article/people-with-long-...
  - timr 4y ago
    Let's be 100% clear: this is all speculation. I take no side on any of it, except to say that the evidence is bad, and what little good evidence there is doesn't support the hyperbolic claims of prevalence, nor does it support the claims of any particular mechanism or theory of what "long covid" is (if anything at all).

timr 4y ago

Take this paper with a huge grain of salt. They went on a fishing expedition, then pointed an ML model at the data and reported some clusters. This is...questionable methodology. ML models will find a way to draw a discriminatory boundary for almost any classification problem. On the other hand, there was this paper [1][2] from the NIH, which was a well-controlled, pre-registered cohort study, did pretty much every clinical test imaginable (about 150 different measurements per person), and found no measurable differences between "long covid" people and controls. This is a much better study, and rebuts the claim. [1] https://www.medpagetoday.com/infectiousdisease/covid19/98885?xid=nl_mpt_DHE_2022-05-23&eun=g1662251d0r https://www.medpagetoday.com/infectiousdisease/covid19/98885... [2] https://www.acpjournals.org/doi/10.7326/M21-4905 https://www.acpjournals.org/doi/10.7326/M21-4905

belltaco 4y ago
People with Long COVID May Still Have Spike Proteins in Their Blood https://www.scientificamerican.com/article/people-with-long-covid-may-still-have-spike-proteins-in-their-blood1/ https://www.scientificamerican.com/article/people-with-long-...
- timr 4y ago
  Let's be 100% clear: this is all speculation. I take no side on any of it, except to say that the evidence is bad, and what little good evidence there is doesn't support the hyperbolic claims of prevalence, nor does it support the claims of any particular mechanism or theory of what "long covid" is (if anything at all).