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NAD & NMN are recent developments in the world of supplements. Read about them a bit, they are natural compounds in the body. Over time our ability to generate

NAD & NMN are recent developments in the world of supplements. Read about them a bit, they are natural compounds in the body. Over time our ability to generate them decreases. Each can have profound effect on things like muscle & tissue repair or lifespan. This is effectively stating the mechanism for utilizing these is shown to be linked to fasting. The efficacies are already proven. A new study which accounts for the activation of the gene and utilization of the supplements will likely show a major therapeutic potential or life extension therapy

ramraj07 4y ago
Citations please? Here’s a snippet from WebMD: > While there is some evidence that suggests NADH supplements might reduce blood pressure, lower cholesterol, help chronic fatigue syndrome by providing energy, and increase nerve signals for people with Parkinson's disease, there isn't enough information to know for sure how or if these supplements work.
- threeseed 4y ago
  This is one of the companies that sells NAD supplements: https://www.elysiumhealth.com https://www.elysiumhealth.com I can't speak to any of their claims but the company is legitimate.
  - ramraj07 4y ago
    They have a clinical trial published; it shows taking the supplement does indeed increase NAD levels. I’m not yet completely convinced personally that this helps, I’m also not persuaded that this does not harm in anyway. Please note the one thing that’s proven again and again in multiple studies: people who take supplements die faster of everything. We don’t know why, and until we do I’m hesitant of increasing my supplement load.
    - krageon 4y ago
      When you have hard to diagnose chronic issues, the first thing a GP will do is give you supplements. Not very surprising the people taking them are at more risk of dying.
      - upsidesinclude 4y ago
        Totally agree, this is the 'vitamin D kills' theory. Nope, doctors just give old people vitD because they are deficient and also old people die. People have are hard time utilizing statistics that actually retain context. In fact, that may be the biggest problem in medicine today.
    - astrange 4y ago
      > Please note the one thing that’s proven again and again in multiple studies: people who take supplements die faster of everything. "Proven" is a strong word unless those are RCTs, or at least, natural experiments. Otherwise the causation issues should be obvious. Related, incorrect birth certificates explain most cases of long-lived humans: https://www.biorxiv.org/content/10.1101/704080v1 https://www.biorxiv.org/content/10.1101/704080v1 Those are more likely in poor regions, which is why those supposed supercentenarians don't take supplements, smoke and eat red meat.
  - rsync 4y ago
    Wouldn’t it be cheaper, easier and less time-consuming to just fast ? Why bother with the unproven, uncertain outcomes of a (commercial) supplement when you can undertake a proven and broadly beneficial action ?
    - upsidesinclude 4y ago
      The problem is that the body stops producing sufficient amounts of NAD. So the fasting would provide better uptake of the supplement. I'm not sure what commercial means to you, but yes it is a synthesized compound, which is also naturally produced in the body.
    - Brian_K_White 4y ago
      It sounds like the fasting is required to best utilize the supplement. So, if you buy into this at all then you need both together. I think fasting alone has already been shown to be beneficial and not harmful, and I don't see enough proof that the supplement doesn't cause some harm from hot-rodding something, but I'm nobody. So, perhaps it's true that supplement alone is of little value, fasting alone is good, and fasting plus supplement is better.
- upsidesinclude 4y ago
  WebMD is not a great resource when it comes to new medicine or even old medicine for that matter, I digress... Found this on the first Google search: https://www.nmn.com/topic https://www.nmn.com/topic Are they selling something, sure, but the studies are all linked. The wide research interest alone should be some indication of the promise these compounds hold

ramraj07 4y ago

Citations please? Here’s a snippet from WebMD: > While there is some evidence that suggests NADH supplements might reduce blood pressure, lower cholesterol, help chronic fatigue syndrome by providing energy, and increase nerve signals for people with Parkinson's disease, there isn't enough information to know for sure how or if these supplements work.

threeseed 4y ago
This is one of the companies that sells NAD supplements: https://www.elysiumhealth.com https://www.elysiumhealth.com I can't speak to any of their claims but the company is legitimate.
- ramraj07 4y ago
  They have a clinical trial published; it shows taking the supplement does indeed increase NAD levels. I’m not yet completely convinced personally that this helps, I’m also not persuaded that this does not harm in anyway. Please note the one thing that’s proven again and again in multiple studies: people who take supplements die faster of everything. We don’t know why, and until we do I’m hesitant of increasing my supplement load.
  - krageon 4y ago
    When you have hard to diagnose chronic issues, the first thing a GP will do is give you supplements. Not very surprising the people taking them are at more risk of dying.
    - upsidesinclude 4y ago
      Totally agree, this is the 'vitamin D kills' theory. Nope, doctors just give old people vitD because they are deficient and also old people die. People have are hard time utilizing statistics that actually retain context. In fact, that may be the biggest problem in medicine today.
  - astrange 4y ago
    > Please note the one thing that’s proven again and again in multiple studies: people who take supplements die faster of everything. "Proven" is a strong word unless those are RCTs, or at least, natural experiments. Otherwise the causation issues should be obvious. Related, incorrect birth certificates explain most cases of long-lived humans: https://www.biorxiv.org/content/10.1101/704080v1 https://www.biorxiv.org/content/10.1101/704080v1 Those are more likely in poor regions, which is why those supposed supercentenarians don't take supplements, smoke and eat red meat.
- rsync 4y ago
  Wouldn’t it be cheaper, easier and less time-consuming to just fast ? Why bother with the unproven, uncertain outcomes of a (commercial) supplement when you can undertake a proven and broadly beneficial action ?
  - upsidesinclude 4y ago
    The problem is that the body stops producing sufficient amounts of NAD. So the fasting would provide better uptake of the supplement. I'm not sure what commercial means to you, but yes it is a synthesized compound, which is also naturally produced in the body.
  - Brian_K_White 4y ago
    It sounds like the fasting is required to best utilize the supplement. So, if you buy into this at all then you need both together. I think fasting alone has already been shown to be beneficial and not harmful, and I don't see enough proof that the supplement doesn't cause some harm from hot-rodding something, but I'm nobody. So, perhaps it's true that supplement alone is of little value, fasting alone is good, and fasting plus supplement is better.
upsidesinclude 4y ago
WebMD is not a great resource when it comes to new medicine or even old medicine for that matter, I digress... Found this on the first Google search: https://www.nmn.com/topic https://www.nmn.com/topic Are they selling something, sure, but the studies are all linked. The wide research interest alone should be some indication of the promise these compounds hold