3 ms·

Hi neuroscientis, maybe you should look into the genetics of you own, and others, gut metabolism. I did and it change my life. (Disabled with Scizoaffective Bip

Hi neuroscientis, maybe you should look into the genetics of you own, and others, gut metabolism. I did and it change my life. (Disabled with Scizoaffective Bipolar Disorder and Ankylosing Spondylitis). I found out I am a FUT2 non-secretor through 23andMe, unusual for a European Caucasian. So basically I cannot fight of gut microbes like you heart farmer folk. Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020113 https://journals.plos.org/plosone/article?id=10.1371/journal... Human genetic variation and the gut microbiome in disease https://www.nature.com/articles/nrg.2017.63 https://www.nature.com/articles/nrg.2017.63 Since FUT2 releases fucose (Not fructose) I decided to see what foods contained fucose and try eating those. Turned out it is very high in seaweed and mushrooms, which is interesting because I have Sami heritage. Also the spuds that changes my gut microbiome were important as well, this meant reducing my short chain PUFAs as low as possible because of my FADS1 and FADS2 genetics. Eating those regularly turned my IBD into IBNormal and it helped my brain and inflammation as well. So "Eat (whole) foods. Not too much. Mostly plants" is quite wrong for me, genetically. In fact, when I was a (good) vegan and vegetarian my HDL was 30 with hyperlipidemia! Eating kind of keto with only seafood pushed my Hal up to 55. As a neuroscientist you should know that Mood Disorders are highly polygenic so there is no same cause and therefore no same cure for anyone. So can you please start looking into personalized medicine so people like me do not have to live in constant hell? Thanks.

amelius 4y ago
> Since FUT2 releases fuctose (Not fructose) Fuctose has no wikipedia page. Could you provide some sources? > I found out I am a FUT2 non-secretor through 23andMe, unusual for a European Caucasian. Wikipedia says: > Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 20% doesn't seem extremely unusual.
- PlatinumHarp 4y ago
  I think it's a typo, it should be Fucose not Fuctose.
- FollowingTheDao 4y ago
  Yes, I fixed the spell check from fructose to fuctose, but not all the way to fucose. 20%, uncommon, unusual, whatever. It is not rare but it is not usual. Still 20% of the people might be eating a diet that is wrong for them. But I suppose you think this does not matter? I mean are you denying the science behind this? Are you denying it helped me?
  - amelius 4y ago
    I was just interested and checking facts, not trying to be judgemental. Thanks for the correction.
    - FollowingTheDao 4y ago
      As you can understand and see I am on a razors edge when it comes to talking about this stuff, and even more so with this in the medical field. It was really the "20% is not unusual" part that skewered me in the brain because before I posted this no one here probably heard of this gene and its strong effect on the microbiome and diet. And now I just want to add, for your interest, that Mood Disorders are not fundamentally neurological, I am sorry to say, but in fact they are immune disorders which affect neurology. You would do the mentally ill a huge favor by sending your patients to rheumatology for care. It has been 50 years since my mother was diagnose with Bipolar Disorder and here I am now, with the same issues, and they are pretty much prescribing the same meds and looking at it in the same way. So whenever I meet a neurologist I have to express my frustration because you need to think about mood disorders in a radically new way if something is to change and being nice did not change anything. And now, when I find things out that help me I get no help from my doctors, just a "glad that worked for you" and the cold shoulder when I ask for more testing.
      - mandmandam 4y ago
        > Mood Disorders are not fundamentally neurological, I am sorry to say, but in fact they are immune disorders which affect neurology This is interesting to me, thank you. The gut-brain link is fascinating. Have you read "The Body Keeps the Score"? There are some absolutely shocking stats in that book about the correlation between early childhood trauma and mood disorders. You may find the stuff about EMDR and reconnecting with the body interesting. That said, BPD is often an outlier; as in, it doesn't respond the same as most others. ... I'm not an expert. But, I think the author of that book would agree with you on the difficulty of presenting new information to doctors/neurologists/psychiatrists. It seems to require a lot of resilience.

amelius 4y ago

> Since FUT2 releases fuctose (Not fructose) Fuctose has no wikipedia page. Could you provide some sources? > I found out I am a FUT2 non-secretor through 23andMe, unusual for a European Caucasian. Wikipedia says: > Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 20% doesn't seem extremely unusual.

PlatinumHarp 4y ago
I think it's a typo, it should be Fucose not Fuctose.
FollowingTheDao 4y ago
Yes, I fixed the spell check from fructose to fuctose, but not all the way to fucose. 20%, uncommon, unusual, whatever. It is not rare but it is not usual. Still 20% of the people might be eating a diet that is wrong for them. But I suppose you think this does not matter? I mean are you denying the science behind this? Are you denying it helped me?
- amelius 4y ago
  I was just interested and checking facts, not trying to be judgemental. Thanks for the correction.
  - FollowingTheDao 4y ago
    As you can understand and see I am on a razors edge when it comes to talking about this stuff, and even more so with this in the medical field. It was really the "20% is not unusual" part that skewered me in the brain because before I posted this no one here probably heard of this gene and its strong effect on the microbiome and diet. And now I just want to add, for your interest, that Mood Disorders are not fundamentally neurological, I am sorry to say, but in fact they are immune disorders which affect neurology. You would do the mentally ill a huge favor by sending your patients to rheumatology for care. It has been 50 years since my mother was diagnose with Bipolar Disorder and here I am now, with the same issues, and they are pretty much prescribing the same meds and looking at it in the same way. So whenever I meet a neurologist I have to express my frustration because you need to think about mood disorders in a radically new way if something is to change and being nice did not change anything. And now, when I find things out that help me I get no help from my doctors, just a "glad that worked for you" and the cold shoulder when I ask for more testing.
    - mandmandam 4y ago
      > Mood Disorders are not fundamentally neurological, I am sorry to say, but in fact they are immune disorders which affect neurology This is interesting to me, thank you. The gut-brain link is fascinating. Have you read "The Body Keeps the Score"? There are some absolutely shocking stats in that book about the correlation between early childhood trauma and mood disorders. You may find the stuff about EMDR and reconnecting with the body interesting. That said, BPD is often an outlier; as in, it doesn't respond the same as most others. ... I'm not an expert. But, I think the author of that book would agree with you on the difficulty of presenting new information to doctors/neurologists/psychiatrists. It seems to require a lot of resilience.