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Diet and its effects on the gut biome in the pathophysiology of mental disorders
- tpoacher 4y agoAndrew Wakefield's original disputed paper was about the brain-gut-microbiome axis. Regardless of what you think of Wakefield, and the disservice he (and/or Brian Deer) did with respect to autism and vaccines, an even bigger tragedy to me is that nobody dared to investigate the BGM axis for decades now, for fear of association. It's good to see it back on the list of acceptable research agendas. Perhaps finally the healing can begin.
- flashfaffe2 4y agoRole of diet and its effects on the gut microbiome in the pathophysiology of mental disorder
- jb1991 4y agotldr: > to date there is insufficient evidence from mechanistic human studies to make conclusions about causality between a specific diet and microbially mediated brain function.
- robg 4y agoI’m a neuroscientist and have struggled with my (mental) health for 30 years. With the pandemic I realized how much foods affect how I feel every day. Going more than 6 months without eating out I became attuned to the differences of meals I prep and what goes into them. The best explanation I’ve heard is food is like explicit instructions for how our bodies and brains perform through our DNA. Gut health is the engine of the biological machine humming or sputtering accordingly. The research is out there on the differences between food types and impacts of processed foods. The Pollan mantra still still sticks with me: Eat (whole) foods. Not too much. Mostly plants. I’ve added: Sleep better. Move more. Stress less. (To eat well.)
- loceng 4y agoIf you haven't yet it's a good idea to do a microbiome stool test kit to see if there is any overgrowth of bad bacteria or yeast in your GI tract, as well an Igg food sensitivity test/food panel for 200+ foods to see if there are any common foods you're regularly or irregularly eating that may be causing inflammation, irritating your GI tract. Also important to note, many plants have toxins in them to prevent animals eating them, and that most research studies on red meat are greatly flawed.
- robg 4y agoSugar and Candida was really eye opening - it’s the fungal overgrowth driving my addiction to sweet stuff.
- groestl 4y agoCan you provide a little more insight/some links on the last paragraph?
- geewee 4y ago> and that most research studies on red meat are greatly flawed. Care to elaborate on this? Preferably with sources.
- amanaplanacanal 4y agoI don’t have any sources for you, but a lot of people have been revisiting saturated fat and cholesterol, and it appears that they probably aren’t as bad for you as we once thought.
- adrian_b 4y agoWhile moderate amounts of saturated fats are not bad, there is no doubt that it is recommended that in the eaten fat the most abundant fatty acid must be oleic acid (i.e. the fat must contain mostly MUFA, mono-unsaturated fatty acids). The reason is simply that oleic acid is the most abundant fatty acid in human fat. When the ingested fat consists mostly of oleic acid, it can be used as such, while when the ingested fat contains either mostly saturated fats, like many animal fats or mostly poly-unsaturated fatty acids, e.g. linoleic acid, like most cheap vegetable oils, the ingested fatty acids must be converted by the liver into the fatty acids preferred inside the human body, so that is extra work for the liver and the liver becomes less efficient at old ages. If the liver does not succeed to convert all the ingested fatty acids that should have been converted, than the composition of the fat used for various purposes in the body may be suboptimal. Examples of foods with optimal fatty acid composition are olive oil, high-oleic sunflower oil (not classic sunflower oil, which contains mostly linoleic acid), hazelnuts, almonds, pistachios, cashews, peanuts.
- crikeyjoe 4y ago
- ryukoposting 4y agoOne time, someone told my girlfriend she should try Keto to help with her Epilepsy. Maybe they were on to something, I guess.
- Cthulhu_ 4y agoI mean no harm no foul, I too have heard mostly anecdotal accounts of diet and various health conditions - migraines, allergies, ADHD, etc. There's plenty of science out there but it's still early.
- memcg 4y agoPer this link. https://charliefoundation.org/am-i-a-candidate/keto-for-epilepsy/ https://charliefoundation.org/am-i-a-candidate/keto-for-epil... "Ketogenic Therapies and brain surgery are the only known cures for Epilepsy. Half of the people with epilepsy who try the diet have a seizure reduction of at least 50%. Up to 25% become completely seizure free. In the sections below, we explain how Ketogenic Therapies compare to anti-epileptic medications, how keto’s mechanisms are thought to affect the body, and stories from a few of the thousands of families who have had amazing results by implementing keto for epilepsy."
- digdugdirk 4y agoThe Ketogenic diet is actually fully effective in many patients. Interestingly, its more commonly used as a "last resort" when patients don't respond to pharmaceutical interventions instead of a first line of treatment. https://my.clevelandclinic.org/health/treatments/7156-ketogenic-diet-keto-diet-for-epilepsy https://my.clevelandclinic.org/health/treatments/7156-ketoge...
- lancesells 4y agoThat's terrible to hear that doctors would try pharmaceuticals before a relatively simple diet change.
- worker_person 4y agoI'm involved in many support forums. A few patterns I've noticed. The people who have been mostly managing their conditions via diet without understanding whats happening. Basically they eat healthy, and it mostly works. People who love food / don't want to cook healthy and refuse to acknowledge the possibility that's causing problems. People who say they eat healthy but really don't. (Salad once a week) Or a variation, people who ate a salad, didn't get better and claim diets don't work). The ones who are at deaths door and are finally desperate enough to try anything. Actually following a strict diet like KETO / AIP. Paying close attention to trigger foods, etc. These ones often can reduce or eliminate medication. Learning to be honest with yourself about food is one of the major challenges. Giving up various food addictions can be brutal.
- pygy_ 4y agoIn the first table the "eating disorders" entry makes references to "Kleinman et al. 2015" and to "Morita et al. 2015". Neither can be found in the bibiography. I couldn't find a paper by some Kleinman on the topic between 2014 and 2016 (https://scholar.google.com/scholar?start=0&q=author:kleinman+anorexia&hl=fr&as_sdt=7,39&as_ylo=2014&as_yhi=2016 https://scholar.google.com/scholar?start=0&q=author:kleinman...). Morita wrote this (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145274 https://journals.plos.org/plosone/article?id=10.1371/journal...). Neither the linked article nor Morita's mention Serguei Fetissov's pioneering work on the topic though, which is disappointing, given that he and his colleagues have long documented the link between E. Coli, the immune system and eating disorders. The gist is that E. Coli produces a protein (CLBP) that mimics a feeding-related hormone (IIRC melanocortin). That protein ends up in the blood stream and can bind the corresponding receptors. It can also generate an immune response, and these antibodies are cross-reactive, causing autoimmunity and complicating the story.
- bluechair 4y agoDo you have any links to his work?
- pygy_ 4y agoPlucking from Google scholar you can check this https://www.pnas.org/doi/full/10.1073/pnas.222658699 https://www.pnas.org/doi/full/10.1073/pnas.222658699 and this https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/eat.22531 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/eat.22531 among many others... https://scholar.google.com/scholar?hl=en&as_sdt=7%2C39&q=serguei+fetissov+bulimia&btnG= https://scholar.google.com/scholar?hl=en&as_sdt=7%2C39&q=ser... A key point is that the same anomalies are seen in anorexia, binge eating and bulimia.
- hrdwdmrbl 4y agoWhat’s the tl;dr? What does it say we should eat?
- bjoli 4y agoI only skimmed the article, but many sections, with the glaring exception being diet and epilepsy, mentioned a Mediterranean style diet, and looking closer at the studies cited it seems like the Mediterranean diet proposed by Low-Carb Satan Ancel Keys. But I didn't read it too closely. One of my favourite YouTubers just released a video on the subject: https://youtu.be/FleMtTEEYlc https://youtu.be/FleMtTEEYlc
- hombre_fatal 4y agoI like that guy too. One of the few nutrition youtubers I can find who seem open minded.
- david_l_lin 4y agoIt's interesting that we've become so obsessed with the gut microbiome even though stool only captures a tiny fraction of the composition of the gut. Similarly, the salivary oral microbiome has also been correlated with mental disorders, cognitive health, is modulated by diet, and plays a major role in systemic health. And saliva is objectively easier to collect. Instead of jumping straight into collecting poop, we should be collecting our spit instead! https://www.nature.com/articles/s41398-022-01922-0 https://www.nature.com/articles/s41398-022-01922-0 https://www.nature.com/articles/s41598-021-94498-6 https://www.nature.com/articles/s41598-021-94498-6
- jklinger410 4y agoI have a chicken and egg issue with microbiome stuff. Does your microbiome look different because you are suffering from an issue, or does your microbiome looking different cause the issue. Kind of like when an auto-immune disorder is causing inflammation. You can treat the inflammation, but you aren't treating the real problem.
- david_l_lin 4y agowell, for the most part in healthcare we treat symptoms not causes. cavities caused by acid producing bacteria? drill and fill gum disease caused by oral dysbiosis? bone and gum grafts diabetes from autoimmunity? insulin high cholesterol from… anything? statins
- aaaaaaaaata 4y agoA great reminder that you are the only one truly held responsible for "figuring out" your health.
- FollowingTheDao 4y agoYes, I can assure you it is bidirectional, since my mental stress certainly affected my gut.
- Karawebnetwork 4y ago
- polskibus 4y agoHow does this study relate to fairly recent topic of lack of evidence that low serotonine levels causes depression ? Should the diet metaanalysis be redone after that study ? https://news.ycombinator.com/item?id=32160703 https://news.ycombinator.com/item?id=32160703
- liberia 4y agoAnyone here drink kefir yogurt? I have kefir grains which I ferment in milk and get a weekly yield of yogurt that I drink out of a bowl after straining the yogurt. It’s packed with probiotics, and helps with my mood. It’s an all round useful elixir to make.
- deleted 4y ago[deleted]
- zucked 4y agoI add Kefir to a lot of dishes (both cooked and uncooked) that call for some dairy component. I actually prefer it to milk in things like pancakes, even though cooking it must kill some/many/all of the probiotics. I was making my own, but I was finding the process a bit more involved than I wanted to deal with, so I just recently started buying pre-made kefir. I can't say that I've experienced a world-altering impact to my life (wow, no more acne and I've lost 22lbs!) but I do think I've been able to eat dairy products (cheese and yogurt) with far less upset stomach than before. Careful with introducing Kefir if you're looking to try it out - start small. I was adding a tablespoon to my dishes and it made me gassy as heck for the first couple of days.
- giraffe_lady 4y agoA few years ago I started making and eating a lot of fermented foods for purely gastronomic reasons, including kefir. I haven't really noticed any obvious changes. I've been on antibiotics twice in this time and do feel like I get my appetite back more quickly after stopping them now. An antibiotic course used to mean weeks or months of poor appetite, nausea and indigestion now it's like 10 days. But that could be coincidence or something else entirely, who knows.
- aszantu 4y agoif i drink a certain brand of kefir before bed i get space dreams 2 out of 3 times, in germany it's called müller milch kefir, good stuff xD can't do it too often since I don't to well with the sugar content of dairy but it's fun! Warped in a space battle once, barely missed some shooting turret and deep dove into a beforehand invisible sun wich was made of blue water filled cells, good thing, dreams don't have to make sense!