3 ms·

If you have a link, I’d be interested in reading the paper!

• timr 4y ago
  Here's one from Cell -- as I said, it's very technical, but the TL;DR is that 84% of CD4+ and 85% of CD8+ memory T cell responses to the Omicron spike protein are preserved, compared to an average of 90% and 87% respectively for the other variants: https://www.sciencedirect.com/science/article/pii/S0092867422000733 https://www.sciencedirect.com/science/article/pii/S009286742... Here's another: https://www.nature.com/articles/s41586-022-04460-3 https://www.nature.com/articles/s41586-022-04460-3 > Between 70% and 80% of the CD4+ and CD8+ T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar for Beta (B.1.351) and Delta (B.1.617.2) variants, despite Omicron harbouring considerably more mutations. In patients who were hospitalized with Omicron infections (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). Thus, despite extensive mutations and reduced susceptibility to neutralizing antibodies of Omicron, the majority of T cell responses induced by vaccination or infection cross-recognize the variant. I may have read a third, but I can't find it easily, and these two should be more than enough to back up what I wrote / get you started.