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It looks it stems from pockets of London inhabited by communities historically resistant vaccination and/or a traveler from a country historically resistant to

It looks it stems from pockets of London inhabited by communities historically resistant vaccination and/or a traveler from a country historically resistant to vaccination who has traveled there. UK Health Security Agency (UKHSA) experts believe a traveller – likely from Pakistan, Afghanistan or Nigeria - shed the virus in their stools after being given the oral polio inoculation.[1][2] It is likely the virus was shed by someone who was recently vaccinated against polio in a country where it has not yet been eradicated, such as Pakistan, Afghanistan or Nigeria.[3] [1] First outbreak of highly infectious polio detected in UK since 1984 – the 6 signs to know https://www.the-sun.com/health/5615177/first-outbreak-highly-infectious-polio-uk-signs/ https://www.the-sun.com/health/5615177/first-outbreak-highly... [2] National incident declared after polio detected in London sewage https://www.youtube.com/watch?v=tz7zsLJqZ7M https://www.youtube.com/watch?v=tz7zsLJqZ7M [3] Traces of polio virus found in London sewage as health officials declare national incident https://news.sky.com/story/traces-of-polio-virus-found-in-london-sewage-as-health-officials-declare-national-incident-12638443 https://news.sky.com/story/traces-of-polio-virus-found-in-lo...

krageon 4y ago
Honestly folks on holiday without vaccinations against such things should not be allowed to move around. It's already bad that they don't care to protect their own community.
- vidarh 4y ago
  In this case the virus is a result of one of the polio vaccines. Whomever brought it would very possibly have done the right thing and gotten vaccinated recently, but the live attenuated polio vaccine very occasionally leads to shed attenuated polio virus reverting to full strength.
  - krageon 4y ago
    And that's definitely the reason they didn't get vaccinated, which probably wasn't fundamentally egocentric at all /s
    - vidarh 4y ago
      Huh? They did get vaccinated. EDIT: It is possible the import could have come from an unvaccinated person too, having gotten it from someone who has been vaccinated. But that the virus is vaccine-derived means the ultimate source is someone who got the vaccine.
- wonderwonder 4y ago
  They were vaccinated... If you read the article, the headline is "Vaccine-derived poliovirus... detected" When you take the oral polio vaccine, its a live virus and sometimes that virus can be spread. So in this case, someone who had likely recently been vaccinated via the oral vaccine used a toilet in London and the virus was detected in the sewers.
- dudeDDRrulez 4y ago
  I realize this might be a shock… But vaccines fail all the time. Their immunity wanes, they cause adverse events and sometimes they spawn rogue strains like what happened with Polio. BTW we have a case study unfolding real time on restricting people’s travel based on vaccination status. As the COVID-19 vaccine does not prevent transmission, infection or spread, it was a complete disaster. Meanwhile unvaccinated people with natural immunity who don’t spread were unfairly punished for noncompliance.
asimpleusecase 4y ago
Your comment is the one everyone needs to read. The vaccine used in the UK is not an attenuated virus. So this was “ imported”. The news is likely being circumspect due to concerns of profiling immigrants or refugees or religious communities most prevalent where this vaccine is used. So far no cases have been found of transmission between people. I would be interested to know the sensitivity of the test they are using.
- easytiger 4y ago
  > I would be interested to know the sensitivity of the test they are using. Bet that isn't discussed anywhere.
  - avs733 4y ago
    So you can't really have sensitivity and specificity in the classic sense because you are not able to gold standard classify the infection of an individual. However, here is some research on the mater... >The location and timing of poliomyelitis cases showed spatial and temporal variability. The sensitivity of AFP surveillance to detect serotype 1 poliovirus infection in a district and its neighbours per month was on average 30.0% (95% CI 24.8–35.8) and increased with the incidence of poliomyelitis cases. The average population sensitivity of a single environmental sample was 59.4% (95% CI 55.4–63.0), with significant variation in site-specific estimates (median varied from 33.3–79.2%). The combined population sensitivity of environmental and AFP surveillance in a given month was on average 98.1% (95% CI 97.2–98.7), assuming four samples per month for each site. https://link.springer.com/article/10.1186/s12879-018-3070-4 https://link.springer.com/article/10.1186/s12879-018-3070-4 >Four quarterly visits were made to 78 ES sites in 21 states of Nigeria, and ES site characteristic data were matched to 1345 samples with an average enterovirus prevalence among sites of 68% (range, 9%–100%). A larger estimated catchment population, high total dissolved solids, and higher pH were associated with enterovirus detection. A random forests model predicted “good” sites (enterovirus prevalence >70%) from measured site characteristics with out-of-sample sensitivity and specificity of 75%. https://academic.oup.com/jid/article/225/8/1377/5818305?login=true https://academic.oup.com/jid/article/225/8/1377/5818305?logi... Other discussion of environmental surveillance for polio: https://journals.asm.org/doi/full/10.1128/AEM.07972-11 https://journals.asm.org/doi/full/10.1128/AEM.07972-11 https://link.springer.com/article/10.1007/s12560-017-9314-4 https://link.springer.com/article/10.1007/s12560-017-9314-4
CommanderData 4y ago
> Pakistan and Afganistan Interesting there was a fake vaccination campaign conducted by our security forces in those countries. https://www.vox.com/first-person/22256595/vaccine-covid-pakistan-cia-program https://www.vox.com/first-person/22256595/vaccine-covid-paki... Which has likely undermined peoples confidence in vaccines from those communities.
- legolas2412 4y ago
  I never understood why this is the position that media has taken. Do you also blame Dr. Fauci for the American vaccine deniers? A doctor worked with American intelligence agencies to find the most wanted terrorist in the world. He is then imprisoned in Pakistan on made up charges, and is still in prison. Does the media sympathize with his plight. No. There is barely any coverage of this after 2012. Instead, the media is so concerned with low vaccination rates. Is there a reason that media seems so biased to ignore a person's plight? A person who should be celebrated like a hero, not blamed like this.
  - aperson_hello 4y ago
    Fauci didn't make a fake covid vaccine. In this fake vaccination program, we endangered health of some of the poorest and most vulnerable people in the world in order to catch someone who had pretty well fallen off the map and wasn't an active threat to anyone for...political points? I have nothing to back this assertion up, but I bet the number of deaths caused by vaccine hesitancy in that part of the world due to this incident is going to dwarf the number who died in 9/11 all said and done. Was that worth it?
    - yonaguska 4y ago
      Fauci didn't make a fake vaccine but he certainly pushed vaccines in a very dishonest manner. He played a huge role in destroying my faith in the CDC and the FDA.
      - dudeDDRrulez 4y ago
Angostura 4y ago
This isn’t an outbreak - probably. It’s someone shedding virus particles following vaccination

krageon 4y ago

Honestly folks on holiday without vaccinations against such things should not be allowed to move around. It's already bad that they don't care to protect their own community.

vidarh 4y ago
In this case the virus is a result of one of the polio vaccines. Whomever brought it would very possibly have done the right thing and gotten vaccinated recently, but the live attenuated polio vaccine very occasionally leads to shed attenuated polio virus reverting to full strength.
- krageon 4y ago
  And that's definitely the reason they didn't get vaccinated, which probably wasn't fundamentally egocentric at all /s
  - vidarh 4y ago
    Huh? They did get vaccinated. EDIT: It is possible the import could have come from an unvaccinated person too, having gotten it from someone who has been vaccinated. But that the virus is vaccine-derived means the ultimate source is someone who got the vaccine.
wonderwonder 4y ago
They were vaccinated... If you read the article, the headline is "Vaccine-derived poliovirus... detected" When you take the oral polio vaccine, its a live virus and sometimes that virus can be spread. So in this case, someone who had likely recently been vaccinated via the oral vaccine used a toilet in London and the virus was detected in the sewers.
dudeDDRrulez 4y ago
I realize this might be a shock… But vaccines fail all the time. Their immunity wanes, they cause adverse events and sometimes they spawn rogue strains like what happened with Polio. BTW we have a case study unfolding real time on restricting people’s travel based on vaccination status. As the COVID-19 vaccine does not prevent transmission, infection or spread, it was a complete disaster. Meanwhile unvaccinated people with natural immunity who don’t spread were unfairly punished for noncompliance.

asimpleusecase 4y ago

Your comment is the one everyone needs to read. The vaccine used in the UK is not an attenuated virus. So this was “ imported”. The news is likely being circumspect due to concerns of profiling immigrants or refugees or religious communities most prevalent where this vaccine is used. So far no cases have been found of transmission between people. I would be interested to know the sensitivity of the test they are using.

easytiger 4y ago
> I would be interested to know the sensitivity of the test they are using. Bet that isn't discussed anywhere.
- avs733 4y ago
  So you can't really have sensitivity and specificity in the classic sense because you are not able to gold standard classify the infection of an individual. However, here is some research on the mater... >The location and timing of poliomyelitis cases showed spatial and temporal variability. The sensitivity of AFP surveillance to detect serotype 1 poliovirus infection in a district and its neighbours per month was on average 30.0% (95% CI 24.8–35.8) and increased with the incidence of poliomyelitis cases. The average population sensitivity of a single environmental sample was 59.4% (95% CI 55.4–63.0), with significant variation in site-specific estimates (median varied from 33.3–79.2%). The combined population sensitivity of environmental and AFP surveillance in a given month was on average 98.1% (95% CI 97.2–98.7), assuming four samples per month for each site. https://link.springer.com/article/10.1186/s12879-018-3070-4 https://link.springer.com/article/10.1186/s12879-018-3070-4 >Four quarterly visits were made to 78 ES sites in 21 states of Nigeria, and ES site characteristic data were matched to 1345 samples with an average enterovirus prevalence among sites of 68% (range, 9%–100%). A larger estimated catchment population, high total dissolved solids, and higher pH were associated with enterovirus detection. A random forests model predicted “good” sites (enterovirus prevalence >70%) from measured site characteristics with out-of-sample sensitivity and specificity of 75%. https://academic.oup.com/jid/article/225/8/1377/5818305?login=true https://academic.oup.com/jid/article/225/8/1377/5818305?logi... Other discussion of environmental surveillance for polio: https://journals.asm.org/doi/full/10.1128/AEM.07972-11 https://journals.asm.org/doi/full/10.1128/AEM.07972-11 https://link.springer.com/article/10.1007/s12560-017-9314-4 https://link.springer.com/article/10.1007/s12560-017-9314-4

CommanderData 4y ago

> Pakistan and Afganistan Interesting there was a fake vaccination campaign conducted by our security forces in those countries. https://www.vox.com/first-person/22256595/vaccine-covid-pakistan-cia-program https://www.vox.com/first-person/22256595/vaccine-covid-paki... Which has likely undermined peoples confidence in vaccines from those communities.

legolas2412 4y ago
I never understood why this is the position that media has taken. Do you also blame Dr. Fauci for the American vaccine deniers? A doctor worked with American intelligence agencies to find the most wanted terrorist in the world. He is then imprisoned in Pakistan on made up charges, and is still in prison. Does the media sympathize with his plight. No. There is barely any coverage of this after 2012. Instead, the media is so concerned with low vaccination rates. Is there a reason that media seems so biased to ignore a person's plight? A person who should be celebrated like a hero, not blamed like this.
- aperson_hello 4y ago
  Fauci didn't make a fake covid vaccine. In this fake vaccination program, we endangered health of some of the poorest and most vulnerable people in the world in order to catch someone who had pretty well fallen off the map and wasn't an active threat to anyone for...political points? I have nothing to back this assertion up, but I bet the number of deaths caused by vaccine hesitancy in that part of the world due to this incident is going to dwarf the number who died in 9/11 all said and done. Was that worth it?
  - yonaguska 4y ago
    Fauci didn't make a fake vaccine but he certainly pushed vaccines in a very dishonest manner. He played a huge role in destroying my faith in the CDC and the FDA.
    - dudeDDRrulez 4y ago

Angostura 4y ago

This isn’t an outbreak - probably. It’s someone shedding virus particles following vaccination