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> Because they are highly dense, perfluorocarbons can also help flush mucus out of the intestine > Introducing oxygen to the intestines would probably kill the
by pazimzadeh 4y ago
> Because they are highly dense, perfluorocarbons can also help flush mucus out of the intestine
> Introducing oxygen to the intestines would probably kill the microbes involved in digestion
Combining these two for any significant amount of time seems like a recipe for microbiota dysbiosis.
It would be interesting to somehow determine if most of the oxygen is absorbed in the small or large intestine.
Mucus is what keeps bacteria from reaching the intestinal epithelium, especially in the large intestine (https://www.pnas.org/doi/10.1073/pnas.0803124105 https://www.pnas.org/doi/10.1073/pnas.0803124105), and oxygenating the gut will cause a bloom in facultative aneorobes including E. coli and Salmonella, while killing anaerobic commensals like Bacteroidetes.
- MrBuddyCasino 4y agoPeople have no idea how important the microbiome is to their health. At the very least, one should make a "backup" of the microbiome so it can be repopulated later in case something goes pear-shaped. Messing with stuff can cause all kinds of endotoxin / auto-immune issues.
- falsaberN1 4y agoI'm no medical science person, but I had surgery a year ago for some type of severe gangrene, and while I miraculously came out whole, I'm still suffering horrible digestive issues that had nothing to do with it, presumably from the antibiotics needed to nuke the bad bacteria (because of intolerance to the one that was more efficient they had to use more indiscriminate solutions). It didn't specifically cause the issues you mention, but it sure caused some.
- 2muchcoffeeman 4y agoI had antibiotics induced digestive problems too. I saw a specialist and the treatment was another cocktail of antibiotics. It worked immediately after taking the first dose.
- justinc8687 4y agoWhat kind of specialist was this?
- 2muchcoffeeman 4y agoA gastroenterologist.
- getcrunk 4y agoGo to sprouts/whholefoods/mother's and get the most expensive probiotics like the emergency 5 day version. Repeat maybe a few weeks after.
- blowski 4y agoI love the thought that one's gut should have an off-site backup for DR purposes.
- interestica 4y agoOne theory is that this is what the role of the appendix is: backup, storage and recovery. https://www.sciencedaily.com/releases/2017/01/170109162333.htm https://www.sciencedaily.com/releases/2017/01/170109162333.h...
- b112 4y agoCurrent backups are in close relatives. They'll take a sample of feces from a relative, liquify it and remove solids, and seed your rear end with the results. Been doing this for decades.
- dayofthedaleks 4y agoTurns out that’s what the appendix is for!
- hawk_ 4y agoHow does one make such a backup?
- dredmorbius 4y agoCore dump and cold storage. https://en.wikipedia.org/wiki/Fecal_microbiota_transplant https://en.wikipedia.org/wiki/Fecal_microbiota_transplant
- pettycashstash2 4y agoRight, First do no harm
- robbiep 4y agoIf you’ve got a tube up your arse so you can breathe through your bowels, you’ve got bigger issues than microbiome ones. Even not needing that but being sick enough they’re considering that (if it was ever adopted) you’re going to have problems / you’re probably on wild cocktails of drugs. It is very unlikely much if any of the tested fluids were reaching the small bowel - between the small and large bowels (you probably know this) you have the iliocaecal valve (which can reflux) but the change in diameter means that even if it was incompetent moving any sort of volume would need a cannulation of that valve