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Scientists Discover Ways of Making Old Blood New Again
- skinney6 4y agoGet a "blood boy" ;)
- pstuart 4y agohttps://hiddenremote.com/2017/05/21/yes-blood-boy-silicon-valley-actually-thing-kinda/ https://hiddenremote.com/2017/05/21/yes-blood-boy-silicon-va...
- tayne 4y agoSo the main problems listed are inflammation, lack of omega 3 and reduction in some kinds of autophagy. All of these can be addressed with an animal based diet or a keto diet plus intermittent fasting. The more I look into it the more I am convinced that a high fat animal based diet with fasting is the healthiest diet.
- worker_person 4y agoYou may be interested in the Autoimmune Protocol Diet. Chief issue of autoimmune issues is inflammation. AIP diet focuses on foods that reduce inflammation. Many (not all!) people in support forums find signifiant relief from following AIP. It is similar to Keto.
- pengaru 4y agoExcept a huge proportion of the meat sold in grocers is low quality corn-fed hormone-ridden garbage. It's far easier to consistently access decent organic produce everywhere I tend to live.
- tayne 4y ago
- joebob42 4y agoSounds interesting, although it's one of those which really probably ought to include "in mice" in the title. Still, there's so much progress being made in health stuff generally. Makes me optimistic about my older years.
- gysfjiutedgj 4y agoMice lie and monkeys exaggerate.
- selimthegrim 4y agoIt’s an irregular verb.
- fnordpiglet 4y agoObviously the mice are hyper intelligent beings tricking us into finding their immortality.
- planetsprite 4y agoLab mice are probably evolving via artificial selection to be more prone to respond to drugs in a way that maximizes paper citations.
- JPLeRouzic 4y agoSomething a bit similar is experiments that use only one, ad hoc, animal disease model. For me it looks too easy to have a successful experiment (and article) if you can choose how you poison the animal. I have always wondered why they did not use a commercial model, and better tested their hypothesis on several, unrelated animal models.
- dmichulke 4y agoStartup idea: Grow black mice that are hyperresponsive and white mice that are hyporesponsive (?) while optimizing for minimum genetic distance. Sell them in equally weighted batches as yin/yang mice ("purely for esthetic reasons, also suitable for lab tests")
- 1-6 4y agoBorage oil seems to be the best source for extraction of Gamma-Linolenic Acid
- wyldfire 4y ago> Borage oil contains amabiline, which is a pyrrolizidine alkaloid that is toxic to your liver. The more borage oil you take, the greater the risk of liver damage from this substance, per the Memorial Sloan Kettering Cancer Center. Look for borage oil certified free of unsaturated pyrrolizidine alkaloids to reduce your risk. From https://www.livestrong.com/article/490323-foods-high-in-gamma-linolenic-acids/ https://www.livestrong.com/article/490323-foods-high-in-gamm...
- dvh 4y agoNothing says spring detox like drinking herbal tea full of unknown alkaloids with unknown dosing.
- RosanaAnaDana 4y agoDon't threaten me with a good time
- orangepurple 4y agoDrink the tea while sitting in a high pressure chamber with 100% oxygen if you want a really good time https://doi.org/10.18632/aging.202188 https://doi.org/10.18632/aging.202188
- TedDoesntTalk 4y ago> The protocol comprised of 60 daily sessions, five sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 minutes with 5-minute air breaks every 20 minutes. Compression/decompression rates were 1 meter/minute How can one person have 60 daily sessions?
- ridgeguy 4y agoNature paper referred to in OP available as pdf here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428053/pdf/nihms-1653609.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428053/pdf/nih...
- sologoub 4y agoCould someone who understands this professionally comment on the findings? There are references to them using “5-fluorouracil (5FU)”, which appears to be a chemotherapy drug.
- adrian_b 4y agoIn old humans, the capacity of producing new blood cells becomes reduced in comparison with young people. The study has identified as the cause why the stem cells which produce blood cells are less able to do that in old people is because they are less efficient in autophagy, i.e. they are less able to destroy the cellular components, e.g. defective proteins, which are no longer needed and which must be recycled. After identifying this cause, they have studied a few methods by which this autophagy capability of the stem cells can be influenced. The simplest method was a treatment with gamma-linolenic acid, a fatty acid that normally can be produced by a young human body in sufficient quantities, but in old people its synthesis rate diminishes, like also for a few other substances, e.g. for long-chain omega-3 fatty acids. The treatment with gamma-linolenic acid was tested successfully both in mice and in human cell cultures, restoring the ability of the stem cells to make new blood cells.
- dav_Oz 4y agoA very potent way to induce autophagy seems to be through fasting [0]. As far as I understand measuring autophagy accurately across different cell types in a living organism/human as autophagy flux is still a big challenge and e.g. Peter Attia emphasizes in his podcasts there is no reliable way to effectively measure autophagy, unfortunately he didn't bother to go in depth. The papers I've found about measuring autophagy are painting a more confident picture, though. [0]https://www.sciencedirect.com/science/article/pii/S1568163718301478?via%3Dihub https://www.sciencedirect.com/science/article/pii/S156816371...
- noipv4 4y agoBlack currant seed oil (contains GLA) in a capsule also helps me with allergies.
- synaesthesisx 4y agoInteresting, that’s the second report I’ve heard of mentioning this effect. Are these seasonal (pollen) allergies?
- dmichulke 4y agoSame for black cumin oil - was recommended by a friend who says she got rid of her allergies completely.
- CommanderData 4y agoDo you have a reference for this.
- _0ffh 4y agoOut of curiosity, do you mean Elwendia Persica or Nigella Sativa?
- dmichulke 4y agoNigella Sativa
- Animats 4y agoJust think, if the recent advances in longevity work out, we could have Putin and Trump around for decades more.
- strogonoff 4y agoAging is quite a sad prospect overall, but as long as everyone is subject to the same process it is a great equalizer of sorts. An unforeseen consequence that is often brought up regarding the philosophy of unlimited or greatly extended human age is that it would exacerbate all inequalities in a society. As it’s well-known, time is the biggest pyramid scheme of them all. On the day of Tiananmen massacre, it occurred to me that it would have even stronger repercussions at country scale. Taking democratic countries’ shift to the policy of non-involvement and combining it with hypothetical advancements that continuously extend Supreme Leaders’ ages essentially sentences generations of dictatorships’ subjects to hardship, exploitation and gaslit life under a kleptocracy. Add to that increased existential threat to democracy, since such a dictator never would have to deal with inefficiencies of internal power and knowledge transfer or spending resources on facilitating an honest voting process, infinitely building connections and spinning its webs around the remaining parts of the free world. One wicked old man interminably learning new ways to turn the world into a zero-sum game and win at it, as generations of servants come and go around him they are even easier to control.
- deleted 4y ago[deleted]
- tayne 4y agoThat’s like saying that one person will dominate the tv show survivor. In reality new cliques and alliances form all the time, power shifts and swirls as alliances coalesce and disperse. We will still have wars and disasters and things that no one person can control. Plus, people will still die just not necessarily from the disease of aging. I often notice that people resist something they are afraid of by thinking it will cause a disaster to change how things are. I think you are subconsciously afraid that it’s too good to be true. In reality it will be like penicillin or vaccines — massive improvement and not much else.
- stevespang 4y ago
- goda90 4y agoToday I learned there are two fatty acids with only a letter difference. Linolenic vs linoleic.
- mdp2021 4y agoPretty important distinction: Linolenic acid is the family of alpha-linolenic acid (ALA) - which is omega-3 ; Linoleic acid is in the family of omega-6
- deleted 4y ago[deleted]
- swader999 4y agoIt's so much easier just to harvest the blood from young children.
- dukeofdoom 4y ago
- wombatpm 4y agoOr you can just convince parents to remove the foreskins from their newborn baby boys. Lot easier to identify on a full term infant.
- dukeofdoom 4y agoThis begs the question, is a Hospital legally able to resell that tissue to the cosmetic industry. Seems more likely that an abortion clinic would be an easier source, if it was illegal, due to fewer people needing to be corrupted. It doesn't seem like Sandra was concerned with how it was sourced at all, other than it came from Korea. The "banality of evil" I guess. Combined with her vanity of trying to look younger. Is why this interview stands out in my mind. Plus she's 57 and has a reputation for looking unusually young for her age.
- barry-cotter 4y agoYes. They can legally sell all that stuff and do.
- h2odragon 4y agoThats what "Pizzagate" was really covering up.
- bpodgursky 4y agoIf the young were very well-compensated for the inconvenience I don't actually have a huge problem with this kind of reverse wealth transfer. Try to balance the scales of the social security and housing market wealth extraction which is (in a metaphorical but more meaningful sense) bleeding the young dry. Giving blood isn't really a big deal for a healthy person.