4 ms·

It’s more about NRP1 than ACE2. NRP1 is how they think it infects the neuron. I changed the subject to summarize/translate what the study was saying. The role

It’s more about NRP1 than ACE2. NRP1 is how they think it infects the neuron. I changed the subject to summarize/translate what the study was saying. The role of NRP1 in human sars2 infection is already well know. This study is just showing the infection in the neuron can/may/does precede it’s appearance in the serum. Also, ACE2 is most certainly expressed in the neurons and his greatly expressed in the hippocampus. https://www.sciencedirect.com/science/article/pii/S2589004220310361 https://www.sciencedirect.com/science/article/pii/S258900422...

timr 4y ago
That is an argument they are making to explain the putative infection of wild-type mice, yes. Maybe it is true, but it doesn't invalidate any of the things I wrote. The headline you used doesn't mention that this is a paper in mice, so you failed to accurately summarize one of the most important parts. So important, in fact, that it's in the title of the paper. Edit: the link you are citing does not say what you're suggesting. "Neuroepithelium" means "epithelial cells surrounding the neurons". The paper is suggesting that they found signs of ACE2 expression in this epithelial tissue.
- FollowingTheDao 4y ago
  I’m sorry, I don’t understand. You didn’t bring up NRP1 At all in your argument when clearly this is what the paper about. SAR2 is entering the neuron via NRP1 and ACE2.
  - timr 4y ago
    They infect mice that express ACE2 on their neurons, and see obvious signs of infection. They also infect wild-type mice, and see greatly reduced response in the same experiment, but claim that this is still non-zero. They hypothesize that NRP1 is mediating the infection. The evidence for this claim is not definitive. It's an intriguing hypothesis. It's still not a paper about humans.
    - FollowingTheDao 4y ago
      The fact that NRP1 assists SARS2 infection has been known for over a year. I still don’t get your point. This is important because it can explain the neurological symptoms of Covid and possible pathway for treatment of those neurological symptoms. To anyone, like me, who had psychosis at the beginning of their Covid infection, or people who are suffering from long Covid, this is very important.
      - timr 4y ago
        There have been papers showing that NRP1 interacts with furin-cleaved spike protein. There have been some suggestions that this assists in entry for non-neural cells. There have never been papers (to my knowledge) that show that this plays a role in neuronal infection in humans. Like ACE2, NRP1 is associated with endothelial cells. Again, this is a research paper, in mice. It has no direct relevance to any symptom you have personally experienced.
        FollowingTheDao 4y ago
        > It has no direct relevance to any symptom you have personally experienced. You say this like the whole story of COVID is finished. Story for you: https://twitter.com/JamesMelville/status/1528046141715230721 https://twitter.com/JamesMelville/status/1528046141715230721
vmception 4y ago
> This study is just showing the infection in the neuron can/may/does precede it’s appearance in the serum. That's pretty interesting, what does this mean for anything. Like does it change how tests should work? vaccines? any mitigation measure?
- FollowingTheDao 4y ago
  It will probably mean a lot regarding cognitive function and psychosis to those are risk genetically. Changes in NRP1 are linked to mood disorders like schizophrenia and depression. I think it also shows that this is the pre-symptomatic time of the infection. My own experiences with Covid was I had a psychotic break two days before I had a fever. I have a history of psychosis. It’s also important to note that the Epstein-Barr virus also uses NRP1. In my humble opinion, I feel that the destruction of NRP1 and ACE2 are responsible for many of the comorbidities we find after infection with SARS2.

timr 4y ago

That is an argument they are making to explain the putative infection of wild-type mice, yes. Maybe it is true, but it doesn't invalidate any of the things I wrote. The headline you used doesn't mention that this is a paper in mice, so you failed to accurately summarize one of the most important parts. So important, in fact, that it's in the title of the paper. Edit: the link you are citing does not say what you're suggesting. "Neuroepithelium" means "epithelial cells surrounding the neurons". The paper is suggesting that they found signs of ACE2 expression in this epithelial tissue.

FollowingTheDao 4y ago
I’m sorry, I don’t understand. You didn’t bring up NRP1 At all in your argument when clearly this is what the paper about. SAR2 is entering the neuron via NRP1 and ACE2.
- timr 4y ago
  They infect mice that express ACE2 on their neurons, and see obvious signs of infection. They also infect wild-type mice, and see greatly reduced response in the same experiment, but claim that this is still non-zero. They hypothesize that NRP1 is mediating the infection. The evidence for this claim is not definitive. It's an intriguing hypothesis. It's still not a paper about humans.
  - FollowingTheDao 4y ago
    The fact that NRP1 assists SARS2 infection has been known for over a year. I still don’t get your point. This is important because it can explain the neurological symptoms of Covid and possible pathway for treatment of those neurological symptoms. To anyone, like me, who had psychosis at the beginning of their Covid infection, or people who are suffering from long Covid, this is very important.
    - timr 4y ago
      There have been papers showing that NRP1 interacts with furin-cleaved spike protein. There have been some suggestions that this assists in entry for non-neural cells. There have never been papers (to my knowledge) that show that this plays a role in neuronal infection in humans. Like ACE2, NRP1 is associated with endothelial cells. Again, this is a research paper, in mice. It has no direct relevance to any symptom you have personally experienced.
      - FollowingTheDao 4y ago
        > It has no direct relevance to any symptom you have personally experienced. You say this like the whole story of COVID is finished. Story for you: https://twitter.com/JamesMelville/status/1528046141715230721 https://twitter.com/JamesMelville/status/1528046141715230721

vmception 4y ago

> This study is just showing the infection in the neuron can/may/does precede it’s appearance in the serum. That's pretty interesting, what does this mean for anything. Like does it change how tests should work? vaccines? any mitigation measure?

FollowingTheDao 4y ago
It will probably mean a lot regarding cognitive function and psychosis to those are risk genetically. Changes in NRP1 are linked to mood disorders like schizophrenia and depression. I think it also shows that this is the pre-symptomatic time of the infection. My own experiences with Covid was I had a psychotic break two days before I had a fever. I have a history of psychosis. It’s also important to note that the Epstein-Barr virus also uses NRP1. In my humble opinion, I feel that the destruction of NRP1 and ACE2 are responsible for many of the comorbidities we find after infection with SARS2.