3 ms·

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get ri

by api 4y ago

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.

pengaru 4y ago
My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
- DoreenMichele 4y ago
  Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
  - SemanticStrengh 4y ago
    And most importantly, sleep and the glymphatic system. There are many substances that promote Autophagy though.
    - DoreenMichele 4y ago
      For the brain, yes. https://news.ycombinator.com/item?id=25427090 https://news.ycombinator.com/item?id=25427090
deleted 4y ago
[deleted]
SemanticStrengh 4y ago
It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators. BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
- ErikAugust 4y ago
  Where does one find Skq1?
  - SemanticStrengh 4y ago
    https://mitolab.com/product/vismotech-skq1-bromide-solution-10ml-30ml/ https://mitolab.com/product/vismotech-skq1-bromide-solution-... You should always coadminister (take at the same time or a bit before) NAC (600mg+) SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process. Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect. It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ Google Skq1 on pubmed to see how great it is
- swader999 4y ago
  Thoughts on fisetin?
bawolff 4y ago
I don't understand why dilluting it would work here - either its filterable and it would get filtered regardless (e.g. drinking water would be enough) or it wont be and the dillutant would just be filtered

by api 4y ago

pengaru 4y ago

My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...

DoreenMichele 4y ago
Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
- SemanticStrengh 4y ago
  And most importantly, sleep and the glymphatic system. There are many substances that promote Autophagy though.
  - DoreenMichele 4y ago
    For the brain, yes. https://news.ycombinator.com/item?id=25427090 https://news.ycombinator.com/item?id=25427090

deleted 4y ago

[deleted]

SemanticStrengh 4y ago

It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators. BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.

ErikAugust 4y ago
Where does one find Skq1?
- SemanticStrengh 4y ago
  https://mitolab.com/product/vismotech-skq1-bromide-solution-10ml-30ml/ https://mitolab.com/product/vismotech-skq1-bromide-solution-... You should always coadminister (take at the same time or a bit before) NAC (600mg+) SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process. Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect. It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ Google Skq1 on pubmed to see how great it is
swader999 4y ago
Thoughts on fisetin?

bawolff 4y ago

I don't understand why dilluting it would work here - either its filterable and it would get filtered regardless (e.g. drinking water would be enough) or it wont be and the dillutant would just be filtered