3 ms·
When covid appeared, I remembered this as a two-part concern. (1) was the damned thing was similar to sars and mers and it was contagious. This is bad. These
by jleyank 5y ago
When covid appeared, I remembered this as a two-part concern. (1) was the damned thing was similar to sars and mers and it was contagious. This is bad. These previous coronaviruses killed people 30-40 by cytokine storm. (2) was the fact that covid was killing old or sick people damn quickly by cytokine storm. There were other effects (heart inflammation) but burning out the lungs was a real concern.
Things turned out way better than they could have due to early, effective vaccines and the omicron mutation. Because of sars/mers, the knew they needed something to throttle down the cytokine storm to prevent killing healthy early middle aged people - that “real strong immune system” people were proud of was the source of the storm.
Like hiv, if the body can’t clear the infection things remain “under attack” and the virus keeps mutating under evolutionary pressure. I thought he feeling was that omicron came from a long term hiv positive or mice (which have a way faster mutation cycle). This kind of allergic response of the immune system is a risk for most new large molecule drugs and is the basis for diseases like RA and IBD.
- nradov 5y agoOnly a fraction of COVID-19 deaths involved cytokine storms. https://doi.org/10.1371/journal.pone.0262438 https://doi.org/10.1371/journal.pone.0262438
- jleyank 5y agoThat's a late-in-the-day paper from this year that discusses treatments. In 2020, there wasn't anything to do at all until they found the steroid so you'd need literature or databases info re: fatalities from Italy or the early US sites. Given various immunosuppressant drugs, the risk of cytokine storm is (greatly?) reduced. That's why everything that was approved for humans and might work in that arena were tried in 2020.