17 ms·
Covid spike protein induces cognitive deficit and anxiety-like behavior in mice
- thanatos519 5y agoOver here, too! I feel like I've had a lobotomy and even after the other symptoms were gone, I have been sleeping an extra 6h a day. I feel like I need a little nap and wake up 3h later.
- codezero 5y agoWe still have a lot to learn from this plague.
- hkt 5y agoI too have become a nap fiend since a bout with covid last year. I can't get through a working day without one now. (I do extend the day afterwards, if anyone is wondering)
- 0des 5y agoI also noticed my needs for sleep went up
- Traubenfuchs 5y ago> I feel like I've had a lobotomy I have been feeling like this for years. But I do know there was a time where I didn‘t feel like that. I wonder if anxiety, an unknown past (viral?) illness, past medication (Isotretinoin, SSRI?) or something else is at fault.
- treeman79 5y agoConsider looking at autoimmune if you have weird issues. Took me 20 years of vague symptoms to get diagnosed.
- Traubenfuchs 5y agoShould I just go to an endocrinologist and tell them I feel like shit? From my experience it‘s pointless to visit any doctor without a serious, clear problem.
- treeman79 5y agoA Rumatologist. endocrinologist Is also a good idea. Make a list of every symptom you have. Get some lab work done. See if there is any outliers. My ANA was off. 1:640 speckled. Doctors kept telling me to ignore it. It ended up being a major clue to keep pushing for more and more testing. You will absolutely be gaslit by doctors at every step of the way. Gotta keep pushing and learning. Join the support forms for chronic illness in Reddit and Facebook. Eventually you’ll see people that are suffering the exact same symptom that you are. They can guide you on what has to take to confirm a rule out various ideas
- Traubenfuchs 5y agoAlright, I will check out my ANA. My general bloodworks, liver, kidney and c-reactive protein are usually completely normal. The thing is, I do suffer from medium to severe anxiety and have trouble sleeping. Those things could be the source of me feeling bad.
- tootie 5y agoLong Covid is turning out to be subtle and pernicious. I would not be surprised to learn that lots of illnesses have long-term complications that have gone unnoticed.
- tonymet 5y agobetter late than never i guess .
- andybak 5y agoThere's such a range of bizarre opinions and hot takes about anything Covid related that it's impossible to even guess what point you're trying to make.
- mckirk 5y agoHe's had a lifelong feud with the lab mouse population and is happy about every blow we can deal to them.
- treeman79 5y agoNew alert. Research causes cancer. In mice.
- JaimeThompson 5y agoHaving read Hitchhikers Guide to the Galaxy I am not sure I would ever be against mice.
- Traubenfuchs 5y agoWhat about the proteins the mrna and vector vaccines turn your cells into factories for, at various locations in your body, for a various amount of time? Is there a difference?
- deleted 5y ago[deleted]
- netizen-936824 5y agoThat's the spike protein
- WithinReason 5y agoThe title refers to the spike protein
- netizen-936824 5y agoOooh that must be what that mrna vaccines tell our cells to make, ey?
- realreality 5y agoThere's one important difference: not everybody who's exposed to SARS-CoV2 will become infected and replicate a large amount of viral proteins. But everybody injected with mRNA will become a spike protein factory.
- croes 5y agoThe vaccine also doesn't lead to a large amount of viral proteins
- vkou 5y agoIt's the same thing, the main difference is that those cells only work that way for a few days, while with an infection, they work that way until the infection clears.
- 5y ago
- Traubenfuchs 5y agoDoes the same happen to humans? Does that kind of damage heal in the majority of humans? How long does healing usually take?
- thenerdhead 5y agoIt took me a little over a year to feel back to normal. That’s cognitive function and reduced anxiety. It introduced depression and anxiety to my life that I never had prior. I’ve had to learn to cope with this and sought solutions every new day. What helped me most was exercise, little to no mainstream news or social media, and getting clearer on my purpose of life. It was a very rough 14 months, but I got through it and feel back to normal.
- ren_engineer 5y agohow much of this could be attributed to the world events surrounding Covid and basically correlation vs causation? There have been studies that the majority of people claiming "long covid" when tested have never actually been infected. Most of the symptoms described could be depression due to being locked in your home and your normal lifestyle disrupted for nearly 3 years now. Plus general anxiety from the negativity of the news in general creating constant doom and gloom even this study is somewhat suspect to me, they injected spike protein directly into the mouse's brain rather than using a natural infection. There's only a single study saying Covid can cross the blood brain barrier, so I'm not sure this methodology translates to real world infection
- pydry 5y agoMy first thought as well. I never caught covid but social isolation definitely induced anxiety and cognitive deficit in me.
- fffobar 5y agoWhat if it was caused by both? I'm in your shoes, and pondering this very question.
- forum_ghost 5y agoIt is both. Social isolation does cause depression and anxiety, as social interaction is a very well proven anti-depressant. Covid is also known to destroy your sense of smell. The olfactory bulb. which is neural tissue in your nose, goes right into your brain, and has no protection from blood brain barrier...because it doesn't have it. Covid is neurotoxic. Isolation does cause depression. Both are true.
- sjmm1989 5y ago
- andybak 5y agoJust to throw in a data point: 2 doses of AZ and one of Pfizer and I feel fine. (well - just the normal cognitive decline :) )
- sjmm1989 5y agoInteresting. Thanks. I don't think I truly lost anything cognitively. I think I may have restored most of any loss that happened. But... I also forced my body to do a niacin flush and other things like that. Not recommending it. Just adding on what I was doing.
- manwe150 5y agoUnless they injected the shot into your hippocampus like the research article (which would be most irregular), the brain-blood barrier probably kept it out?
- sjmm1989 5y agoProbably correct, but I still felt very similar effects to what is described. Or so I think. So... what am I supposed to say? Nothing? Fuck that.
- emerged 5y agoOur entire family was sick and it crushed us for 2-3 weeks. This description sounds like it applies to us too. I take anxiety medicine and it’s like it completely stopped working. Yet none of us tested positive for COVID. I don’t know what that means. It could mean we had COVID but the tests were wrong. It could mean we didn’t have COVID but the flu had similar impact. Just have no idea what to think about anything anymore. Edit: downvote away. This is my literal life as it occurred. I’m not making a political statement I have absolutely no idea what to make of it.
- selectodude 5y ago>Yet none of us tested positive for COVID. It sounds mostly like you all got a nasty flu.
- emerged 5y agoThat has been my assumption. Part of the family had also already had COVID. They said this was much worse than COVID, which I would assume is because we are all vaccinated and it was most likely the milder Omnicron variant. Not skipping the flu vaccine next year! Although I think this years vaccine was rather weak unfortunately.
- flenserboy 5y agoAnd that's part of why it's best to stay as far away from this virus and its nasty little bits as possible, no matter its method of entering the body.
- rubyist5eva 5y agoUnless you go live on a deserted island somewhere or dee in the woods away from civilization for the next 50 years that’s not realistic at all.
- jthrowsitaway 5y ago> deep in the woods Then the deer with Covid will get you!
- rubyist5eva 5y agofoiled again!
- Gatsky 5y ago> Eight-week-old mice were used for the spike protein injections. S1 protein was purchased from Acrobiosystems (Cat #S1N-C52H4, Newark, DE, USA), and used after polymixin B (Cat #P1004, Sigma-Aldrich, St. Louis, MO, USA) treatment (30 µg/ml). The animals were anesthetized with isoflurane, and the injection paths were drilled into their skulls. Then, 5 µg of S1 protein (1 µg/µl) were bilaterally injected into each hippocampal region using a Hamilton syringe (Cat #80330, Hamilton Company, Reno, NV, USA) attached to a syringe pump (Cat #53311, Stoelting Co., Wood Dale, IL, USA) at a constant volume of 0.5 µl/min. I think we can all agree that injecting huge amounts of viral protein into your brain is not recommended. This study did not include a control group which received non-spike protein viral antigens (from say influenza which is also known to cause neurocognitive problems). As such it does not prove any specific neurotoxic effect of Covid19. The mechanistic studies in the paper suggest it is non-specific inflammation which causes neuronal cell death.
- forum_ghost 5y ago
- civilized 5y agoReminds me of the study that said long COVID symptoms were strongest in people who thought they had COVID but never actually got it. Some areas of science experience a lot of swirl. Eggs are good for you on Tuesday and bad for you on Thursday.
- foolfoolz 5y agosomething like 80%+ covid deaths were co-morbid with obesity. this idea that everyone is susceptible to long covid or permanent outcomes is garbage
- vkou 5y agoIt's a good thing that the risk of becoming obese can be reduced dramatically by two free vaccinations a year, then. (Also, your second claim does not follow from the first.)
- smegsicle 5y agohttps://hnrankings.info/30901029/ https://hnrankings.info/30901029/ dropped from 4 to 33 between 23:00 and 23:05
- forum_ghost 5y agowhat does that mean?
- ajma 5y agoGood thing I'm not a mouse
- timbit42 5y agoYou are both mammals.